Alcohol and other drug withdrawal: practice guidelines.

Clinical guidelines seek to direct clinical practice by outlining recognised, evidence-based treatment interventions. They draw on current literature and clinical practice expertise. These Guidelines provide guidance for clinical decision-making in the context of individual client requirements, withdrawal setting, treatment availability and individual service protocols. These Guidelines are consistent with the World Health Organisation’s (WHO) United Nations Principles of Drug Dependence Treatment (United Nations Office on Drugs and Crime and World Health Organization, 2008). They outline current best practice for the management of AOD-dependent clients accessing withdrawal care. 1 Introduction - page 1 2 Definitions of dependence and withdrawal - page 5 3 Principles of AOD withdrawal care - page 9 4 Continuity of Care - page 11 5 Features of AOD withdrawal - page 13 6 Special needs groups - page 19 7 Presentation to AOD withdrawal - page 29 8 AOD withdrawal settings - page 31 9 Assessment - page 37 10 Alcohol withdrawal - page 45 11 Opioid withdrawal - page 65 12 Benzodiazepines - page 87 13 Amphetamine-type substances (ATS) - page 99 14 Cannabis - page 111 15 Nicotine - page 121 16 AOD withdrawal for clients with a dual diagnosis - page 133 17 References - page 16

A Whole-Genome RNA Interference Screen Reveals a Role for Spry2 in Insulin Transcription and the Unfolded Protein Response.

Insulin production by the pancreatic β-cell is required for normal glucose homeostasis. While key transcription factors that bind to the insulin promoter are known, relatively little is known about the upstream regulators of insulin transcription. Using a whole-genome RNA interference screen, we uncovered 26 novel regulators of insulin transcription that regulate diverse processes including oxidative phosphorylation, vesicle traffic, and the unfolded protein response (UPR). We focused on Spry2-a gene implicated in human type 2 diabetes by genome-wide association studies but without a clear connection to glucose homeostasis. We showed that Spry2 is a novel UPR target and its upregulation is dependent on PERK. Knockdown of Spry2 resulted in reduced expression of Serca2, reduced endoplasmic reticulum calcium levels, and induction of the UPR. Spry2 deletion in the adult mouse β-cell caused hyperglycemia and hypoinsulinemia. Our study greatly expands the compendium of insulin promoter regulators and demonstrates a novel β-cell link between Spry2 and human diabetes

Ethnographies of Power

What does it mean to work with radical concepts in our time of rampant inequality, imperial-capitalist plunder, racial/sexual/class violence and ecocide? When concepts from the past seem inadequate, how do scholars and activists concerned with social change decide what concepts to work with or renew? The contributors to Ethnographies of Power address these questions head on. Gillian Hart is a key thinker in radical political economy, geography, development studies, agrarian studies and Gramscian critique of postcolonial capitalism. In Ethnographies of Power each contributor engages her work and applies it to their own field of study. These applied concepts include: ‘gendered labour’ practices among South African workers, reading ‘racial capitalism’ through agrarian debates, using ‘relational comparison’ in an ethnography of schooling across Durban, reworking ‘multiple socio-spatial trajectories’ in Guatemala’s Maya Biosphere Reserve, critiquing the notion of South Africa’s ‘second economy’, revisiting ‘development’ processes and ‘Development’ discourses in US military contracting, reconsidering Gramsci’s ‘conjunctures’ geographically, finding divergent ‘articulations’ in Cape Town land occupations, and exploring ‘nationalism’ as central to revaluing recyclables at a Soweto landfill. Ethnographies of Power offers an invaluable toolkit for activists and scholars engaged in sharpening their critical concepts for the social and environmental change necessary for our collective future

Auditory sequence processing reveals evolutionarily conserved regions of frontal cortex in macaques and humans.

An evolutionary account of human language as a neurobiological system must distinguish between human-unique neurocognitive processes supporting language and evolutionarily conserved, domain-general processes that can be traced back to our primate ancestors. Neuroimaging studies across species may determine whether candidate neural processes are supported by homologous, functionally conserved brain areas or by different neurobiological substrates. Here we use functional magnetic resonance imaging in Rhesus macaques and humans to examine the brain regions involved in processing the ordering relationships between auditory nonsense words in rule-based sequences. We find that key regions in the human ventral frontal and opercular cortex have functional counterparts in the monkey brain. These regions are also known to be associated with initial stages of human syntactic processing. This study raises the possibility that certain ventral frontal neural systems, which play a significant role in language function in modern humans, originally evolved to support domain-general abilities involved in sequence processing