ASCIE: An integrated experiment to study CSI in large segmented optical systems

A description of the advanced structures/control integrated experiment (ASCIE) experimental setup, a generic test bed for several essential technologies was presented. In particular its multi-input, multi-output, non-collocated control system and its complex structural dynamics, characteristic of large segmented systems make it an ideal test bed for Control-Structure Interaction (CSI) experiments. The high accuracy of its measurement system will make it possible to investigate the dynamics of microvibrations and its implication for the CSI phenomenon

Application of a full potential method for analysis of complex aircraft geometries

A supersonic potential flow solver was developed to analyze the flow over complex realistic aircraft geometries. Enhancements to the method were made to accommodate regions of subsonic flow, the effect of trailing wakes on other aircraft components, and the modeling/gridding of complete configurations. Validation of the method was demonstrated by comparisons with experimental aerodynamic force and surface pressure measurements. The predicted results are in very good agreement with the experimental data. The bibliography contains additional information on the use of the potential flow code to predict the aerodynamics of high-speed wing/body configurations, waverider concepts, TAV, and the Space Shuttle orbiter package

The LIFE Model: Livelihood Improvement through Facilitated Extension

The previous papers (Menz; Puerto et al.; Johnson et al.; Johnson et al., this issue) provided a background context for the development of an extension model thought to be applicable in conflict-vulnerable areas of Mindanao. This was done by developing and using an extension model that is effective and resource efficient, as well as sufficiently flexible to be adapted to local community needs. First in this chapter, learnings from previous extension work are listed. From those learnings, a set of sixteen extension principles are derived. These extension principles are categorized under the umbrella of three overarching and concurrent extension strategies: (1) improving access to technical innovations, (2) building community social capital, and (3) collaborating closely with local institutional partners. Finally a set of practical activities that defines the model is specified, while recognizing the need for flexibility in responding to prevailing circumstances

Stress and Reliability Analysis of a Metal-Ceramic Dental Crown

Interaction of mechanical and thermal stresses with the flaws and microcracks within the ceramic region of metal-ceramic dental crowns can result in catastrophic or delayed failure of these restorations. The objective of this study was to determine the combined influence of induced functional stresses and pre-existing flaws and microcracks on the time-dependent probability of failure of a metal-ceramic molar crown. A three-dimensional finite element model of a porcelain fused-to-metal (PFM) molar crown was developed using the ANSYS finite element program. The crown consisted of a body porcelain, opaque porcelain, and a metal substrate. The model had a 300 Newton load applied perpendicular to one cusp, a load of 30ON applied at 30 degrees from the perpendicular load case, directed toward the center, and a 600 Newton vertical load. Ceramic specimens were subjected to a biaxial flexure test and the load-to-failure of each specimen was measured. The results of the finite element stress analysis and the flexure tests were incorporated in the NASA developed CARES/LIFE program to determine the Weibull and fatigue parameters and time-dependent fracture reliability of the PFM crown. CARES/LIFE calculates the time-dependent reliability of monolithic ceramic components subjected to thermomechanical and/Or proof test loading. This program is an extension of the CARES (Ceramics Analysis and Reliability Evaluation of Structures) computer program

Class-based probability estimation using a semantic hierarchy

This article concerns the estimation of a particular kind of probability, namely, the probability of a noun sense appearing as a particular argument of a predicate. In order to overcome the accompanying sparse-data problem, the proposal here is to define the probabilities in terms of senses from a semantic hierarchy and exploit the fact that the senses can be grouped into classes consisting of semantically similar senses. There is a particular focus on the problem of how to determine a suitable class for a given sense, or, alternatively, how to determine a suitable level of generalization in the hierarchy. A procedure is developed that uses a chi-square test to determine a suitable level of generalization. In order to test the performance of the estimation method, a pseudo-disambiguation task is used, together with two alternative estimation methods. Each method uses a different generalization procedure; the first alternative uses the minimum description length principle, and the second uses Resnik's measure of selectional preference. In addition, the performance of our method is investigated using both the standard Pearson chi-square statistic and the log-likelihood chi-square statistic

Modeling dynamic controls on ice streams: a Bayesian statistical approach

Our main goal is to exemplify the study of ice-stream dynamics via Bayesian statistical analysis incorporating physical, though imperfectly known, models using data that are both incomplete and noisy. The physical-statistical models we propose account for these uncertainties in a coherent, hierarchical manner. The initial modeling assumption estimates basal shear stress as equal to driving stress, but subsequently includes a random corrector process to account for model error. The resulting stochastic equation is incorporated into a simple model for surface velocities. Use of Bayes\u27 theorem allows us to make inferences on all unknowns given basal elevation, surface elevation and surface velocity. The result is a posterior distribution of possible values that can be summarized in a number of ways. For example, the posterior mean of the stress field indicates average behavior at any location in the field, and the posterior standard deviations describe associated uncertainties. We analyze data from the \u27Northeast Greenland Ice Stream\u27 and illustrate bow scientific conclusions may be drawn from our Bayesian analysis

Cyclooxygenase-2 expression in oligodendrocytes increases sensitivity to excitotoxic death

<p>Abstract</p> <p>Background</p> <p>We previously found that cyclooxygenase 2 (COX-2) was expressed in dying oligodendrocytes at the onset of demyelination in the Theiler's murine encephalomyelitis virus-induced demyelinating disease (TMEV-IDD) model of multiple sclerosis (MS) (Carlson et al. J.Neuroimmunology 2006, 149:40). This suggests that COX-2 may contribute to death of oligodendrocytes.</p> <p>Objective</p> <p>The goal of this study was to examine whether COX-2 contributes to excitotoxic death of oligodendrocytes and potentially contributes to demyelination.</p> <p>Methods</p> <p>The potential link between COX-2 and oligodendrocyte death was approached using histopathology of MS lesions to examine whether COX-2 was expressed in dying oligodendrocytes. COX-2 inhibitors were examined for their ability to limit demyelination in the TMEV-IDD model of MS and to limit excitotoxic death of oligodendrocytes <it>in vitro</it>. Genetic manipulation of COX-2 expression was used to determine whether COX-2 contributes to excitotoxic death of oligodendrocytes. A transgenic mouse line was generated that overexpressed COX-2 in oligodendrocytes. Oligodendrocyte cultures derived from these transgenic mice were used to examine whether increased expression of COX-2 enhanced the vulnerability of oligodendrocytes to excitotoxic death. Oligodendrocytes derived from COX-2 knockout mice were evaluated to determine if decreased COX-2 expression promotes a greater resistance to excitotoxic death.</p> <p>Results</p> <p>COX-2 was expressed in dying oligodendrocytes in MS lesions. COX-2 inhibitors limited demyelination in the TMEV-IDD model of MS and protected oligodendrocytes against excitotoxic death <it>in vitro</it>. COX-2 expression was increased in wild-type oligodendrocytes following treatment with Kainic acid (KA). Overexpression of COX-2 in oligodendrocytes increased the sensitivity of oligodendrocytes to KA-induced excitotoxic death eight-fold compared to wild-type. Conversely, oligodendrocytes prepared from COX-2 knockout mice showed a significant decrease in sensitivity to KA induced death.</p> <p>Conclusions</p> <p>COX-2 expression was associated with dying oligodendrocytes in MS lesions and appeared to increase excitotoxic death of oligodendrocytes in culture. An understanding of how COX-2 expression influences oligodendrocyte death leading to demyelination may have important ramifications for future treatments for MS.</p