The Problem of Authority in the Theology of Alexander Campbell

The Bible and the Bible alone is the creed of the Protestants was an important statement. It startled the Protestant world, and eventually brought a reformation era into the thought and theology of the Protestants in America in the nineteenth century

RE-EXAMINING & REPOSITIONING HIGHER EDUCATION: TWENTY ECONOMIC AND DEMOGRAPHIC FACTORS DRIVING ONLINE AND BLENDED PROGRAM ENROLLMENTS

Economic and demographic shifts in the United State are transforming higher education. With substantial reductions in state funding, increasing campus energy and operational costs, endowments generating reduced returns, and a national economic readjustment of unprecedented proportions, higher education must re-examine and reposition itself to meet new and emerging challenges. This paper identifies ten economic factors and ten demographic factors that are confronting colleges and universities and driving online and blended program enrollments. While traditional face-to-face programs will always play a critical role in higher education, online and blended programs provide new opportunities to expand current student markets by offering quality programming that supports the institutional mission, increases brand recognition, and expands an institution’s alumni base

Individualized Chemistry for the Gifted Student

Through a Teacher Incentive Award from the Iowa Department of Public Instruction, the honors chemistry course of Ames Senior High School has been converted into a packet form. The packets are flexible enough so the gifted chemistry student may be integrated into the chemistry B sections or the packets may be used for a separate honors chemistry class. The flexible sequencing allows the same topics to be studied concurrently with the chemistry B students

How Dry Seasons Affect Landscape Plants

Because Kentucky had subnormal amounts and uneven distribution of rainfall during the last five to 10 years, you may be worried about your landscape plants. Having invested time and money in these plants, now you need to take protective measures to keep them alive. Landscape plants probably suffer more from moisture-related problems than from any other cause. Because of water, plants experience feast or famine, flood or drought, air or suffocation. Plants are 70 to 90% water, which is essential for plant growth, manufacture of food, and nutrient transport. However, too much water can be a problem. Excess water often causes a plant’s decline and death, because when water fills the soil’s pore spaces, roots can no longer get air, and they die

The Ursinus Weekly, April 4, 1938

Weekly board selects Dunn editor to succeed Groff • Concert by musical groups planned for Thursday • Peace conference play to be Aria de capo • Socialism is path around barriers, Holmes implies • Women to elect governing heads Wednesday • Weekly men at INA hear LaFollette • Co-ed vocation talks after Easter • Nominate Wimer, Bartholomew for YMCA presidency • Meistersingers take Garner up, offer to speed up Congress by singing sweet music at nation\u27s capital • Curtain Club accepts 15 at spring tryouts • Dr. Brownback plans trip • Sheeder lauds acting in junior play • Regional alumni groups plan get-togethers • Committees chosen for May Day pageant • Mr. Michael reveals alumni cooperate in getting jobs for graduates • Ex-Weekly editor runs for state legislature • Gigantic bill ready for third annual scraps carnival Wed. • Lineup uncertain in opener with \u27Cats this Thursday • Elect Jing Johnson to presidency of diamond loop • Politics and verse gain at expense of fiction in second Lantern of year • Berks County mathematical club to banquet here tomorrow • Vespers speaker urges students to follow Christ\u27s teachings • TKA meet to have four from Ursinus • Ruby photographers namedhttps://digitalcommons.ursinus.edu/weekly/1896/thumbnail.jp

Epitope Addition and Ablation via Manipulation of a Dengue Virus Serotype 1 Infectious Clone

ABSTRACT Despite the clinical relevance, dengue virus (DENV) research has been hampered by the absence of robust reverse genetic systems to manipulate the viral serotypes for propagation and generation of mutant viruses. In this article, we describe application of an infectious clone system for DENV serotype 1 (DENV1). Similar to previous clones in both flaviviruses and coronaviruses, the approach constructs a panel of contiguous cDNAs that span the DENV genome and can be systematically and directionally assembled to produce viable, full-length viruses. Comparison of the virus derived from the infectious clone with the original viral isolate reveals identical sequence, comparable endpoint titers, and similar focus staining. Both focus-forming assays and percent infection by flow cytometry revealed overlapping replication levels in two different cell types. Moreover, serotype-specific monoclonal antibodies (MAbs) bound similarly to infectious clone and the natural isolate. Using the clone, we were able to insert a DENV4 type-specific epitope recognized by primate MAb 5H2 into envelope (E) protein domain I (EDI) of DENV1 and recover a viable chimeric recombinant virus. The recombinant DENV1 virus was recognized and neutralized by the DENV4 type-specific 5H2 MAb. The introduction of the 5H2 epitope ablated two epitopes on DENV1 EDI recognized by human MAbs (1F4 and 14C10) that strongly neutralize DENV1. Together, the work demonstrates the utility of the infectious clone and provides a resource to rapidly manipulate the DENV1 serotype for generation of recombinant and mutant viruses. IMPORTANCE Dengue viruses (DENVs) are significant mosquito-transmitted pathogens that cause widespread infection and can lead to severe infection and complications. Here we further characterize a novel and robust DENV serotype 1 (DENV1) infectious clone system that can be used to support basic and applied research. We demonstrate how the system can be used to probe the antigenic relationships between strains by creating viable recombinant viruses that display or lack major antibody epitopes. The DENV1 clone system and recombinant viruses can be used to analyze existing vaccine immune responses and inform second-generation bivalent vaccine designs

Use of Integrated SPECT/CT Imaging for Tumor Dosimetry in I-131 Radioimmunotherapy: A Pilot Patient Study

Abstract Integrated systems combining functional (single-photon emission computed tomography; SPECT) imaging with anatomic (computed tomography; CT) imaging have the potential to greatly improve the accuracy of dose estimation in radionuclide therapy. In this article, we present the methodology for highly patient-specific tumor dosimetry by utilizing such a system and apply it to a pilot study of 4 follicular lymphoma patients treated with I-131 tositumomab. SPECT quantification included three-dimensional ordered-subset expectation-maximization reconstruction and CT-defined tumor outlines at each time point. SPECT/CT images from multiple time points were coupled to a Monte Carlo algorithm to calculate a mean tumor dose that incorporated measured changes in tumor volume. The tumor shrinkage, defined as the difference between volumes drawn on the first and last CT scan (a typical time period of 15 days) was in the range 5%-49%. The therapy-delivered mean tumor-absorbed dose was in the range 146-334cGy. For comparison, the therapy dose was also calculated by assuming a static volume from the initial CT and was found to underestimate this dose by up to 47%. The agreement between tracer-predicted and therapy-delivered tumor-absorbed dose was in the range 7%-21%. In summary, malignant lymphomas can have dramatic tumor regression within days of treatment, and advanced imaging methods allow for a highly patient-specific tumor-dosimetry calculation that accounts for this regression.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/78152/1/cbr.2008.0568.pd

Illinois Cave Amphipod ( Gammarus acherondytes ) Recovery Plan

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Mycobacterial infections in a large Virginia hospital, 2001-2009

<p>Abstract</p> <p>Background</p> <p>In areas where both tuberculosis (TB) and nontuberculous mycobacteria (NTM) are prevalent, descriptive studies of the clinical features of individual mycobacteria are needed to inform clinical triage.</p> <p>Methods</p> <p>We queried the University of Virginia Clinical Data Repository for all mycobacterial infections from 2001-2009.</p> <p>Results</p> <p>Of 494 mycobacterial infections in 467 patients there were 22 species. Patients with pulmonary Tb were more likely to be reported as immigrants (p < 0.001) and less likely to have a predisposing risk factor for NTM (pre-existing lung disease or host predisposition; p = 0.002). Review of chest CT scans revealed that TB infection was more likely to exhibit cavities and pleural effusion than NTM infection (p < 0.05). Among NTM infections <it>M. kansasii</it>, <it>M. xenopi</it>, and <it>M. fortuitum </it>were more likely than MAC to have cavities. There were at least 83 patients that met criteria for NTM lung disease and these were caused by 9 species. <it>M. abscessus </it>infection was associated with cystic fibrosis and <it>M. xenopi </it>infection was associated with male gender.</p> <p>Conclusions</p> <p>In our center mycobacterial infections were common and of diverse species. Immigrant status, cavities, and effusion were associated with TB vs. NTM.</p