Late Noachian development of the Coprates rise, Mars

The Coprates rise forms a 900 km long, north to northeast trending ridge south of Coprates Chasma between long. 56 and 60 degs. Radar and stereo photogrammetric data indicate that the rise is 2 to 4 km above a neighboring trough to the east. The break in slope between the rise and this trough is well defined topographically and in Viking images. In turn, the trough is bordered to the to the east at long. 52 deg by a much gentler rise. West of the Coprates rise, the terrain dips about 0.2 deg to roughly long. 75 deg. The rise and flanking highs were previously interpreted to be tilted fault blocks formed by either Tharsis tectonism or an ancient impact. Results are now reported of a preliminary geologic study that documents Late Noachian growth of the Coprates rise as a asymmetric fold. More comprehensive work will lead to a mechanical analysis of the kinematic development of the rise. It is concluded that the Coprate rise formed during the Late Noachian by 2 to 4 km of asymmetric uplift (steeper on its east flank). The timing is inconsistent with an origin by an early impact, but it coincides in time with early Tharsis centered radial faulting at Syria Planum

TNF-Receptor Inhibitor Therapy for the Treatment of Children with Idiopathic Pneumonia Syndrome. A Joint Pediatric Blood and Marrow Transplant Consortium and Children's Oncology Group Study (ASCT0521)

AbstractIdiopathic pneumonia syndrome (IPS) is an acute, noninfectious lung disorder associated with high morbidity and mortality after hematopoietic cell transplantation. Previous studies have suggested a role for TNFα in the pathogenesis of IPS. We report a multicenter phase II trial investigating a soluble TNF-binding protein, etanercept (Enbrel, Amgen, Thousand Oaks, CA), for the treatment of pediatric patients with IPS. Eligible patients were < 18 years old, within 120 days after transplantation, and with radiographic evidence of a diffuse pneumonitis. All patients underwent a pretherapy broncho-alveolor lavage (BAL) to establish the diagnosis of IPS. Systemic corticosteroids (2.0 mg/kg/day) plus etanercept (.4 mg/kg twice weekly × 8 doses) were administered. Response was defined as survival and discontinuation of supplemental oxygen support by day 28 of study. Thirty-nine patients (median age, 11 years; range, 1 to 17) were enrolled, with 11 of 39 patients nonevaluable because of identification of pathogens from their pretherapy BAL. In the remaining 28 patients, the median fraction of inspired oxygen at study entry was 45%, with 17 of 28 requiring mechanical ventilation. Complete responses were seen in 20 (71%) patients, with a median time to response of 10 days (range, 1 to 24). Response rates were higher for patients not requiring mechanical ventilation at study entry (100% versus 53%, P = .01). Overall survival at 28 days and 1 year after therapy were 89% (95% confidence interval [CI], 70% to 96%) and 63% (95% CI, 42% to 79%), respectively. Plasma levels of proinflammatory cytokines were significantly increased at onset of therapy, subsequently decreasing in responding patients. The addition of etanercept to high-dose corticosteroids was associated with high response rates and survival in children with IPS

The Effect of Multiple Scattering on the Polarization from Binary Star Envelopes. I. Self- and Externally Illuminated Disks

We present the results of a Monte Carlo radiative transfer code that calculates the polarization produced by multiple Thomson scattering and variable absorptive opacity in a circumstellar disk around one component of a close detached binary system. We consider in detail the polarization variations over the binary cycle that result from the disk's illumination by the external star and by its own volume emission. We identify key features of these polarization phase curves and investigate their behavior as functions of optical depth, albedo, and inclination for geometrically thin and thick disks. The polarization due to disk self-illumination is sensitive to the internal optical characteristics of the disk, while the polarization arising from external illumination is mainly sensitive to the disk's geometrical thickness. With appropriate flux weighting, these results, combined with those for an internally illuminated disk, allow simulation of the polarization signature from an arbitrary binary-disk system.Comment: 34 pages, 17 figures. Submitted to ApJ, revised in response to referee comments. Color figures available from http://www.ruf.rice.edu/~jhoffman/monte/colorfigs.htm