332 research outputs found
7-Chloro-1,2-dihydrofuro[2,3-c]isoquinolin-5-amine
In the title compound, C11H9ClN2O, the fused-ring system is essentially planar, with a maximum deviation of 0.0323 (16) Å. In the crystal, molecules are connected by N—H⋯O hydrogen bonds forming a zigzag chain along the c axis. Molecules are further stacked along the a axis through weak π–π interactions, the shortest distance between ring centroids being 3.6476 (8) Å
Notes on sphere-based universal extra dimensions
Hideto Dohi, Takuya Kakuda, Kenji Nishiwaki, Kin-ya Oda, Naoya Okuda. Notes on sphere-based universal extra dimensions. https://arxiv.org/abs/1406.1954
Contribution of human organic anion transporter 3-mediated transport of a major linezolid metabolite, PNU-142586, in linezolid-induced thrombocytopenia
Wang D., Ikemura K., Hasegawa T., et al. Contribution of human organic anion transporter 3-mediated transport of a major linezolid metabolite, PNU-142586, in linezolid-induced thrombocytopenia. Biomedicine and Pharmacotherapy 175, 116801 (2024); https://doi.org/10.1016/j.biopha.2024.116801.Thrombocytopenia, a common adverse effect of linezolid, often occurs in patients lacking typical risk factors. In this study, we investigated the key risk factors for linezolid-induced thrombocytopenia using two real-world clinical databases and explored its underlying mechanism through in vitro and in vivo experiments. In a retrospective analysis of 150 linezolid-treated patients, multivariate analysis identified coadministration of lansoprazole, a proton pump inhibitor, as a significant independent risk factor for thrombocytopenia (odds ratio: 2.33, p = 0.034). Additionally, analysis of the Food and Drug Administration Adverse Event Reporting System database revealed a reporting odds ratio of thrombocytopenia for lansoprazole of 1.64 (95% CI: 1.25–2.16). In vitro studies showed that the uptake of PNU-142586, a major linezolid metabolite, was significantly higher in human organic anion transporter 3-expressing HEK293 (HEK-hOAT3) cells compared to HEK-pBK cells. The apparent IC50 value of lansoprazole against hOAT3-mediated transport of PNU-142586 was 0.59 ± 0.38 µM. In a pharmacokinetic study using rats, coadministration of linezolid with lansoprazole intravenously resulted in approximately a 1.7-fold increase in the area under the plasma concentration-time curve of PNU-142586, but not linezolid and PNU-142300. Moreover, PNU-142586, but not linezolid, exhibited concentration-dependent cytotoxicity in a human megakaryocytic cell line. These findings suggest that linezolid-induced thrombocytopenia should be due to delayed elimination of PNU-142586. Furthermore, delayed elimination of PNU-142586 due to renal failure and hOAT3-mediated transport inhibition by lansoprazole should exacerbate linezolid-induced thrombocytopenia
Heavy Higgs at Tevatron and LHC in Universal Extra Dimension Models
Universal Extra Dimension (UED) models tend to favor a distinctively heavier
Higgs mass than in the Standard Model (SM) and its supersymmetric extensions
when the Kaluza-Klein (KK) scale is not much higher than the electroweak one,
which we call the weak scale UED, in order to cancel the KK top contributions
to the T-parameter. Such a heavy Higgs, whose production through the gluon
fusion process is enhanced by the KK top loops, is fairly model independent
prediction of the weak scale UED models regardless of the brane-localized mass
structure at the ultraviolet cutoff scale. We study its cleanest possible
signature, the Higgs decay into a Z boson pair and subsequently into four
electrons and/or muons, in which all the four-momenta of the final states can
be measured and both the Z boson masses can be checked. We show that the weak
scale UED model may account for the 2sigma excess of this event at ATLAS at the
ZZ pair invariant mass around 250GeV, at which scale SM background is
sufficiently small and the SM Higgs predicts too few events. We have also
studied the Higgs mass 500GeV (and also 700GeV with \sqrt{s}=14TeV) and have
found that we can observe significant resonance with the integrated luminosity
10fb^{-1} for six dimensional UED models.Comment: (v1) 36 pages, 9 figures, 6 tables; (v2) Accepted for publication in
Phys. Rev. D, factor 2 error in (93) corrected, comments and references
added, figures redrawn; (v3) Minor changes including typo corrections in
eq.(15), final version appearing in PR
Higgs at ILC in Universal Extra Dimensions in Light of Recent LHC Data
We present bounds on all the known universal extra dimension models from the latest Higgs search data at the Large Hadron Collider, taking into account the Kaluza-Klein (KK) loop effects on the dominant gluon-fusion production and on the diphoton/digluon decay. The lower bound on the KK scale is from 500GeV to 1TeV depending on the model. We find that the Higgs production cross section with subsequent diphoton decay can be enhanced by a factor 1.5 within this experimental bound, with little dependence on the Higgs mass in between 115GeV and 130GeV. We also show that in such a case the Higgs decay branching ratio into a diphoton final state can be suppressed by a factor 80%, which is marginally observable at a high energy/luminosity option at the International Linear Collider. The Higgs production cross section at a photon-photon collider can also be suppressed by a similar factor 90%, being well within the expected experimental reach.Takuya Kakuda, Kenji Nishiwaki, Kin-ya Oda, Naoya Okuda, Ryoutaro Watanabe. Higgs at ILC in Universal Extra Dimensions in Light of Recent LHC Data. https://arxiv.org/abs/1202.6231
Molecular dynamics simulations on interaction between dislocation and Y2O3 nanocluster in FE
For a new insight on the mechanical properties of oxide dispersion strengthened (ODS) steels from atomistic viewpoints, we have implemented molecular dynamics simulations on the interaction between Y2O3 nanocluster and dislocation in bcc Fe. There is so far no all-round interatomic potential function that can represent all the bonding state, i.e. metal, ion and covalent systems, so that we have adopted rough approximation. That is, each atom in Y2O3 is not discriminated but treated as “monatomic” pseudo-atom; and its motion is represented with the simple pairwise potential function as same as Johnson potential for Fe. The potential parameters are fitted to the energy change in the hcp infinite crystal, by using the ab-initio density functional theory(DFT) calculation for explicitly discriminated Y and O. We have set edge/screw dislocation in the centre of periodic slab cell, and approached it to the “YO” monatomic nano-cluster coherently precipitated in bcc-Fe matrix. The dislocation behavior is discussed by changing the size and periodic distance of the nano-cluster. Among the many useful results, we have obtained a conclusion that the edge dislocation is strongly trapped by YO sphere larger than the diameter of d =0 .9nm, while the screw dislocation shows various behavior, e.g. it cuts through the precipiate without remarkable resistance if the dislocation line tension is high, or it changes the slip plane leaving jogs at the position anterior to the precipiate with loose line tensio
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