Phenomenology of flavorful composite vector bosons in light of BB anomalies

We analyze the flavor structure of composite vector bosons arising in a model of vectorlike technicolor, often called hypercolor (HC), with eight flavors that form a one-family content of HC fermions. Dynamics of the composite vector bosons, referred to as HC rho in this paper, are formulated together with HC pions by the hidden local symmetry (HLS), in a way analogous to QCD vector mesons. Then coupling properties to the standard model (SM) fermions, which respect the HLS gauge symmetry, are described in a way that couplings of the HC rhos to the left-handed SM quarks and leptons are given by a well-defined setup as taking the flavor mixing structures into account. Under the present scenario, we discuss significant bounds on the model from electroweak precision tests, flavor physics, and collider physics. We also try to address B anomalies in processes such as B -> K(*) mu+ mu- and B -> D(*) tau nu, recently reported by LHCb, Belle, (ATLAS, and CMS in part.) Then we find that the present model can account for the anomaly in B -> K(*) mu+ mu- consistently with the other constraints while it predicts no significant deviations in B -> D(*) tau nu from the SM, which can be examined in the future Belle II experiment. The former is archived with the form C9 = -C10 of the Wilson coefficients for effective operators of b -> s mu+ mu-, which has been favored by the recent experimental data. We also investigate current and future experimental limits at the Large Hadron Collider (LHC) and see that possible collider signals come from dijet and ditau, or dimuon resonant searches for the present scenario with TeV mass range. To conclude, the present b -> s mu+ mu- anomaly is likely to imply discovery of new vector bosons in the ditau or dimuon channel in the context of the HC rho model. Our model can be considered as a UV completion of conventional U(1)' model.Comment: 62 pages, 8 figures, 3 tables, typos modified, published versio

Simultaneous interpretation of KK and BB anomalies in terms of chiral-flavorful vectors

We address the presently reported significant flavor anomalies in the Kaon and $B$ meson systems such as the CP violating Kaon decay ($\epsilon'/\epsilon$) and lepton-flavor universality violation in $B$ meson decays ($R_{K^{(*)}},{R_{D^{(*)}}}$), by proposing flavorful and chiral vector bosons as the new physics constitution at around TeV scale. The chiral-flavorful vectors (CFVs) are introduced as a 63-plet of the global $SU(8)$ symmetry, identified as the one-family symmetry for left-handed quarks and leptons in the standard model (SM) forming the 8-dimensional vector. Thus the CFVs include massive gluons, vector leptoquarks, and $W',Z'$-type bosons, which are allowed to have flavorful couplings with left-handed quarks and leptons, and flavor-universal couplings to right-handed ones, where the latter arises from mixing with the SM gauge bosons. The flavor texture is assumed to possess a "minimal" structure to be consistent with the current flavor measurements on the $K$ and $B$ systems. Among the presently reported significant flavor anomalies in the Kaon and $B$ meson systems ($\epsilon'/\epsilon$, $R_{K^{(*)}}, {R_{D^{(*)}}}$), the first two $\epsilon'/\epsilon$ and $R_{K^{(*)}}$ anomalies can simultaneously be interpreted by the presence of CFVs, the ${R_{D^{(*)}}}$ anomaly is predicted not to survive, due to the approximate $SU(8)$ flavor symmetry. Remarkably, we find that as long as both of the $\epsilon'/\epsilon$ and $R_{K^{(*)}}$ anomalies persist beyond the SM, the CFVs predict the enhanced $K^+ \to \pi^+ \nu \bar{\nu}$ and $K_L \to \pi^0 \nu \bar{\nu}$ decay rates compared to the SM values, which will readily be explored by the NA62 and KOTO experiments, and they will also be explored in new resonance searches at the Large Hadron Collider.Comment: 52 pages, 14 figures, 1 table, version published in JHE

Single-Shot Global Localization via Graph-Theoretic Correspondence Matching

This paper describes a method of global localization based on graph-theoretic association of instances between a query and the prior map. The proposed framework employs correspondence matching based on the maximum clique problem (MCP). The framework is potentially applicable to other map and/or query modalities thanks to the graph-based abstraction of the problem, while many of existing global localization methods rely on a query and the dataset in the same modality. We implement it with a semantically labeled 3D point cloud map, and a semantic segmentation image as a query. Leveraging the graph-theoretic framework, the proposed method realizes global localization exploiting only the map and the query. The method shows promising results on multiple large-scale simulated maps of urban scenes

Evaluating contributions of natural language parsers to protein–protein interaction extraction

Motivation: While text mining technologies for biomedical research have gained popularity as a way to take advantage of the explosive growth of information in text form in biomedical papers, selecting appropriate natural language processing (NLP) tools is still difficult for researchers who are not familiar with recent advances in NLP. This article provides a comparative evaluation of several state-of-the-art natural language parsers, focusing on the task of extracting protein–protein interaction (PPI) from biomedical papers. We measure how each parser, and its output representation, contributes to accuracy improvement when the parser is used as a component in a PPI system

クカンブ カクサン キョウチョウ MRI ガゾウ ノ リンショウ オウヨウ ト ユウヨウセイ

Recently the usefulness of diffusion-weighted MR imaging（DWI）in the body regions was reported in several studies. Various malignant tumors may show high signal intensity on DWI reflecting their high cellularity. Quantitative measurement of apparent diffusion coefficient（ADC）may be of value in distinguishing between benign and malignant tumors. We reviewed clinical application of body DWI in various diseases in this article

Difference of signal change by a language task on autistic patients using functional MRI

[Objective] Cerebral function with a language task was evaluated by functional magnetic resonance imaging (fMRI), and the differences of activated pattern and signal changes were compared between autistic patients and normal controls. [Methods] Ten autistic and ten normal subjects were tested by fMRI with a language task requiring the attribution of complex mental states. Activation maps analyzed between two groups were generated and the asymmetry indexes calculated by the quotient of activated pixels of the right frontal lobe divided by those of the left frontal lobe were statistically compared by unpaired t-test. [Results] Both the autistic and the normal subjects showed activation at the bilateral prefrontal cortical areas and the ventral occipito-temporal regions. However, the autistic patients demonstrated more activation at the right frontal lobe than the normal controls. Thus it was considered that in the autistic patients the right-hemisphere was more dominant for the language task than that of the normal controls. The result is consist to the theory that autism is related to early left-hemisphere dysfunction. [Conclusions] We considered that fMRI may be a useful non-invasive method to evaluate the cerebral functional abnormality in autistic patients

Generation of a Mutant Mucor hiemalis Endoglycosidase That Acts on Core-fucosylated N-Glycans

Endo-β-N-acetylglucosaminidase M (Endo-M), an endoglycosidase from the fungus Mucor hiemalis, is a useful tool for chemoenzymatic synthesis of glycoconjugates, including glycoprotein-based therapeutics having a precisely defined glycoform, by virtue of its transglycosylation activity. Although Endo-M has been known to act on various N-glycans, it does not act on core-fucosylated N-glycans, which exist widely in mammalian glycoproteins, thus limiting its application. Therefore, we performed site-directed mutagenesis on Endo-M to isolate mutant enzymes that are able to act on mammalian-type core-α1,6-fucosylated glycans. Among the Endo-M mutant enzymes generated, those in which the tryptophan at position 251 was substituted with alanine or asparagine showed altered substrate specificities. Such mutant enzymes exhibited increased hydrolysis of a synthetic α1,6-fucosylated trimannosyl core structure, whereas their activity on the afucosylated form decreased. In addition, among the Trp-251 mutants, the W251N mutant was most efficient in hydrolyzing the core-fucosylated substrate. W251N mutants could act on the immunoglobulin G-derived core-fucosylated glycopeptides and human lactoferrin glycoproteins. This mutant was also capable of transferring the sialyl glycan from an activated substrate intermediate (sialyl glyco-oxazoline) onto an α1,6-fucosyl-N-acetylglucosaminyl biotin. Furthermore, the W251N mutant gained a glycosynthase-like activity when a N175Q substitution was introduced and it caused accumulation of the transglycosylation products. These findings not only give insights into the substrate recognition mechanism of glycoside hydrolase family 85 enzymes but also widen their scope of application in preparing homogeneous glycoforms of core-fucosylated glycoproteins for the production of potent glycoprotein-based therapeutics