New polyimide polymer has excellent processing characterisitcs with improved thermo-oxidative and hydrolytic stabilities

Polyimide P10P and its processing technique apply to most high temperature plastic products, devices and castings. Prepolymer, when used as varnish, impregnates fibers directly and is able to be processed into advanced composities. Material may also be used as molding powder and adhesive

Girls’ visual representations of literacy in a rural Ugandan community

This Ugandan‐based study examined how visual modes of communication provide insights into girls’ perceptions of literacy, and open broader dialogues on literacy, women, and development. Twenty‐nine primary school girls used drawing and 15 secondary school girls used photography to depict local literacy practices in relation to their own lives and experiences. The images they captured provide a window on the interface between local and global literacy practices, and the “freedoms” (Sen, 1999) associated with literacy. Drawing and photography move beyond language to make visible the barriers that have historically marginalized and excluded girls from full participation in the development process

Fluorescent probes of the orientation of myosin regulatory light chains in relaxed, rigor, and contracting muscle.

The orientation of the light-chain region of myosin heads in relaxed, rigor, and isometrically contracting fibers from rabbit psoas muscle was studied by fluorescence polarization. Cysteine 108 of chicken gizzard myosin regulatory light chain (cgRLC) was covalently modified with iodoacetamidotetramethylrhodamine (iodo-ATR). Native RLC of single glycerinated muscle fibers was exchanged for labeled cgRLC in a low [Mg2+] rigor solution at 30 degrees C. Troponin and troponin C removed in this procedure were replaced. RLC exchange had little effect on active force production. X-ray diffraction showed normal structure in rigor after RLC exchange, but loss of axial and helical order in relaxation. In isolated myofibrils labeled cgRLC was confined to the regions of the sarcomere containing myosin heads. The ATR dipoles showed a preference for orientations perpendicular to the fiber axis, combined with limited nanosecond rotational motion, in all conditions studied. The perpendicular orientation preference was more marked in rigor than in either relaxation or active contraction. Stretching relaxed fibers to sarcomere length 4 microns to eliminate overlap between actin- and myosin-containing filaments had little effect on the orientation preference. There was no change in orientation preference when fibers were put into rigor at sarcomere length 4.0 microns. Qualitatively similar results were obtained with ATR-labeled rabbit skeletal RLC

Editorial Overview: Myosins in Review.

This is the author accepted manuscript. The final version is available from Wiley via https://doi.org/10.1111/tra.1240

Thermally stable laminating resins Final report

Polyimide resin and resin reinforced composite

Reinforced structural plastics

Reinforced polyimide structures are described. Reinforcing materials are impregnated with a suspension of polyimide prepolymer and bonded together by heat and pressure to form a cured, hard-reinforced, polyimide structure

Dystrophin and utrophin: the missing links!

AbstractThere is considerable sequence homology between dystrophin and utrophin, both at the protein and DNA level, and consequently it was assumed that their domain structures and functions would be similar. As more of the detailed biochemical and cell biological properties of these two proteins become known, so it becomes clear that there are subtle if not significant differences between them. We review recent findings and present new hypotheses into the structural and functional properties of the actin-binding domain, central coiled-coil region and regulatory/membrane protein-binding regions of dystrophin and utrophin

Molecular roles of Myo1c function in lipid raft exocytosis.

Lipid rafts are highly dynamic membrane subdomains enriched in specific protein and lipid components that create specialized 'organizing' platforms essential for an array of important cellular functions. The role of lipid rafts in membrane trafficking involves the constant remodelling of the plasma membrane through membrane uptake and balanced exocytosis of intracellular membranes. Our lab has identified the first motor protein, myosin 1c (Myo1c) involved in driving the recycling of lipid-raft enriched membranes from the perinuclear recycling compartment to the cell surface. This newly discovered role for Myo1c in lipid raft exocytosis is crucial for cell spreading, migration and pathogen entry; key cellular processes that require cell surface expansion and plasticity. Here we present a model suggesting Myo1c's possible molecular functions in lipid raft recycling and discuss its wider implications for important cellular functions

Multimodality and English education in Ugandan schools

In this article, we have made the case that multimodal pedagogies that include drawing, photography and drama have significant potential for enhancing teachers’ understanding of the way English is incorporated into students’ lives and how students can improve their understanding and use of the English language. In many ways, multimodal pedagogies represent a hybridization of indigenous and contemporary forms of communication. Drawings, as Vygotsky (1 12-1 13) notes, are children’s earliest representations of experience and stimulate their narrative impulse to create stories. By complementing such drawings with written narratives, teachers might encourage younger children to experiment not only with diverse reader identities, but also a range of writer identities. With reference to photography, it is clear that the careful and rigorous process of taking pictures of meaningful places, people and events gives children a sense of ownership over their worlds. As Norton (145-146) notes, ownership of meaning-making is crucial for the development of literacy. What makes the use of photography particularly effective is the contextual use of reading, writing, listening and speaking activities. Finally, we have argued that drama provides the opportunity for students to experiment with different forms of English, and that the writing of plays and poems used for dramatic performance complement the oral and visual dimensions of performance

Myosins, Actin and Autophagy.

Myosin motor proteins working together with the actin cytoskeleton drive a wide range of cellular processes. In this review, we focus on their roles in autophagy - the pathway the cell uses to ensure homeostasis by targeting pathogens, misfolded proteins and damaged organelles for degradation. The actin cytoskeleton regulated by a host of nucleating, anchoring and stabilizing proteins provides the filament network for the delivery of essential membrane vesicles from different cellular compartments to the autophagosome. Actin networks have also been implicated in structurally supporting the expanding phagophore, moving autophagosomes and enabling efficient fusion with the lysosome. Only a few myosins have so far been shown to play a role in autophagy. Non-muscle myosin IIA functions in the early stages delivering membrane for the initial formation of the autophagosome, whereas myosin IC and myosin VI are involved in the final stages providing specific membranes for autophagosome maturation and its fusion with the lysosome.This is the final version of the article. It first appeared from Wiley via http://dx.doi.org/10.1111/tra.1241