Chronic Stress, Sense of Belonging, and Depression Among Survivors of Traumatic Brain Injury

To test whether chronic stress, interpersonal relatedness, and cognitive burden could explain depression after traumatic brain injury (TBI). Design : A nonprobability sample of 75 mild-to-moderately injured TBI survivors and their significant others, were recruited from five TBI day-rehabilitation programs. All participants were within 2 years of the date of injury and were living in the community. Methods : During face-to-face interviews, demographic information, and estimates of brain injury severity were obtained and participants completed a cognitive battery of tests of directed attention and short-term memory, responses to the Perceived Stress Scale, Interpersonal Relatedness Inventory, Sense of Belonging Instrument, Neurobehavioral Functioning Inventory, and Center for Epidemiological Studies Depression Scale;. Findings : Chronic stress was significantly and positively related to post-TBI depression. Depression and postinjury sense of belonging were negatively related. Social support and results from the cognitive battery did not explain depression. Conclusions : Postinjury chronic stress and sense of belonging were strong predictors of post-injury depression and are variables amenable to interventions by nurses in community health, neurological centers, or rehabilitation clinics. Future studies are needed to examine how these variables change over time during the recovery process.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72593/1/j.1547-5069.2002.00221.x.pd

Species abundance distributions: moving beyond single prediction theories to integration within an ecological framework

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/75247/1/j.1461-0248.2007.01094.x.pd

Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses

To understand neurological complications of COVID-19 better both acutely and for recovery, we measured markers of brain injury, inflammatory mediators, and autoantibodies in 203 hospitalised participants; 111 with acute sera (1–11 days post-admission) and 92 convalescent sera (56 with COVID-19-associated neurological diagnoses). Here we show that compared to 60 uninfected controls, tTau, GFAP, NfL, and UCH-L1 are increased with COVID-19 infection at acute timepoints and NfL and GFAP are significantly higher in participants with neurological complications. Inflammatory mediators (IL-6, IL-12p40, HGF, M-CSF, CCL2, and IL-1RA) are associated with both altered consciousness and markers of brain injury. Autoantibodies are more common in COVID-19 than controls and some (including against MYL7, UCH-L1, and GRIN3B) are more frequent with altered consciousness. Additionally, convalescent participants with neurological complications show elevated GFAP and NfL, unrelated to attenuated systemic inflammatory mediators and to autoantibody responses. Overall, neurological complications of COVID-19 are associated with evidence of neuroglial injury in both acute and late disease and these correlate with dysregulated innate and adaptive immune responses acutely

The bioscope system—testing and validating a novel sensor for aqueous solutions

A novel device called the Bioscope System is investigated for feasibility as sensor for chemicals in aqueous solutions. Thereby a sample is probed by a pulsed voltage and electrical properties of that sample are measured. These electrical properties can be considered as a sum parameter of the sample in terms of conductivity and permittivity. It is demonstrated that the Bioscope System can indeed measure differences between different substances in aqueous solution and between different concentrations of the same substance in aqueous solution. A qualitative explanation is provided. Possible improvements of the system are suggested.Изучено новое устройство Bioscope System для возможного использования в качестве сенсора химических веществ в водных растворах. Посредством сенсора образец зондируется пульсирующим напряжением и измеряются его электрические свойства, которые могут рассматриваться как суммарный параметр в выражении электропроводности и электрической емкости. Продемонстрировано, что Bioscope System может действительно измерять различия между разными веществами и разными концентрациями одних и тех же веществ в водном растворе. Предлагаются возможные усовершенствования системы.Вивчено нове облаштування Bioscope System для можливого використання як сенсора хімічних речовин у водних розчинах. За допомогою сенсора зразок зондується пульсуючою напругою і вимірюються його електричні властивості, які можуть розглядатися як сумарний параметр у вираженні електропровідності і електричної місткості. Продемонстровано, що Bioscope System може дійсно вимірювати відмінності між різними речовинами і різними концентраціями одних і тих же речовин у водному розчині. Пропонуються можливі удосконалення системи