7,095 research outputs found

    Estimations of the Distances of Stellar Collapses in the Galaxy by Analyzing the Energy Spectrum of Neutrino Bursts

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    The neutrino telescopes of the present generation, depending on their specific features, can reconstruct the neutrino spectra from a galactic burst. Since the optical counterpart could be not available, it is desirable to have at hand alternative methods to estimate the distance of the supernova explosion using only the neutrino data. In this work we present preliminary results on the method we are proposing to estimate the distance from a galactic supernova based only on the spectral shape of the neutrino burst and assumptions on the gravitational binding energy released an a typical supernova explosion due to stellar collapses.Comment: Proceedings of the Second International Symposium on Strong Electromagnetic Fields and Neutron Stars (SMFNS 2011) Instituto de Cibern\'etica, Matem\'atica y F\'isica (ICIMAF) Sociedad Cubana de F\'isica (SCF) Varadero, Cuba, 5-7 May 201

    Quantum Symmetries and Strong Haagerup Inequalities

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    In this paper, we consider families of operators {xr}rΛ\{x_r\}_{r \in \Lambda} in a tracial C^\ast-probability space (A,ϕ)(\mathcal A, \phi), whose joint \ast-distribution is invariant under free complexification and the action of the hyperoctahedral quantum groups {Hn+}nN\{H_n^+\}_{n \in \N}. We prove a strong form of Haagerup's inequality for the non-self-adjoint operator algebra B\mathcal B generated by {xr}rΛ\{x_r\}_{r \in \Lambda}, which generalizes the strong Haagerup inequalities for \ast-free R-diagonal families obtained by Kemp-Speicher \cite{KeSp}. As an application of our result, we show that B\mathcal B always has the metric approximation property (MAP). We also apply our techniques to study the reduced C^\ast-algebra of the free unitary quantum group Un+U_n^+. We show that the non-self-adjoint subalgebra Bn\mathcal B_n generated by the matrix elements of the fundamental corepresentation of Un+U_n^+ has the MAP. Additionally, we prove a strong Haagerup inequality for Bn\mathcal B_n, which improves on the estimates given by Vergnioux's property RD \cite{Ve}

    Oral dosing for antenatal corticosteroids in the Rhesus macaque.

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    Antenatal corticosteroids (ACS) are standard of care for women at risk of preterm delivery, although choice of drug, dose or route have not been systematically evaluated. Further, ACS are infrequently used in low resource environments where most of the mortality from prematurity occurs. We report proof of principle experiments to test betamethasone-phosphate (Beta-P) or dexamethasone-phosphate (Dex-P) given orally in comparison to the clinical treatment with the intramuscular combination drug beta-phosphate plus beta-acetate in a Rhesus Macaque model. First, we performed pharmacokinetic studies in non-pregnant monkeys to compare blood levels of the steroids using oral dosing with Beta-P, Dex-P and an effective maternal intramuscular dose of the beta-acetate component of the clinical treatment. We then evaluated maternal and fetal blood steroid levels with limited fetal sampling under ultrasound guidance in pregnant macaques. We found that oral Beta is more slowly cleared from plasma than oral Dex. The blood levels of both drugs were lower in maternal plasma of pregnant than in non-pregnant macaques. Using the pharmacokinetic data, we treated groups of 6-8 pregnant monkeys with oral Beta-P, oral Dex-P, or the maternal intramuscular clinical treatment and saline controls and measured pressure-volume curves to assess corticosteroid effects on lung maturation at 5d. Oral Beta-P improved the pressure-volume curves similarly to the clinical treatment. Oral Dex-P gave more variable and nonsignificant responses. We then compared gene expression in the fetal lung, liver and hippocampus between oral Beta-P and the clinical treatment by RNA-sequencing. The transcriptomes were largely similar with small gene expression differences in the lung and liver, and no differences in the hippocampus between the groups. As proof of principle, ACS therapy can be effective using inexpensive and widely available oral drugs. Clinical dosing strategies must carefully consider the pharmacokinetics of oral Beta-P or Dex-P to minimize fetal exposure while achieving the desired treatment responses
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