Innovation Policy and Chronic Emergencies

The COVID-19 pandemic has thrust the potential role of the state as a driver of scientific innovation onto center stage. Vaccines have been developed and brought to market in a timescale that seemed almost impossible when the crisis first struck. The pivotal nature of government intervention in this crisis has added to calls from academics and policy makers to adopt a more proactive, mission-oriented approach to innovation policy to tackle other key global challenges. This Article considers the merits of these calls and argues that an important distinction must be drawn between what this Article terms acute and chronic emergencies. COVID-19 is a paradigmatic example of an acute emergency: its onset was rapid, its impact was dramatic, and it is a problem that demands resolution for life to proceed “as normal.” Chronic emergencies, such as the problem of Anti-Microbial Resistance, can be just as, or more deadly than, acute emergencies but have a “frog in the pot” quality. They emerge over time, and, although they can have profound social and economic effects, they do so in ways that are less immediate and hence less demanding of government attention. Without the urgency, sense of purpose, and spirit of cooperation that accompany acute emergencies, there is a risk that mission-oriented approaches may fail to deliver new technologies the world urgently needs. This Article considers the problem of applying mission-oriented approaches to chronic emergencies. The analysis is grounded in an examination of Britain’s system of innovation rewards in the eighteenth and nineteenth centuries, drawing on an extensive historical data set that the authors are continuing to develop. The central argument put forward in this Article is that Britain’s historical system offers lessons for crafting state intervention to spur innovation aimed at chronic emergencies today. Britain’s historical system was effective because rewards were largely bestowed post hoc with relatively little prescription as to the problems at which innovators should direct their efforts, and still less as to the methods and means that should be used to tackle them. Perhaps most importantly, these rewards fed into and helped create a culture of innovation. The Article concludes with a proposal for change—namely, that the way innovation prizes are designed should be reconsidered. Prizes must preserve space for scientific and technical freedom and ought not to be built around the sort of rigidly defined criteria that proponents of mission-oriented innovation policies often advocate

High-Resolution In-Vivo Analysis of Normal Brain Response to Cranial Irradiation

Radiation therapy (RT) is a widely accepted treatment strategy for many central nervous system (CNS) pathologies. However, despite recognized therapeutic success, significant negative consequences are associated with cranial irradiation (CR), which manifests months to years post-RT. The pathophysiology and molecular alterations that culminate in the long-term detrimental effects of CR are poorly understood, though it is thought that endothelial injury plays a pivotal role in triggering cranial injury. We therefore explored the contribution of bone marrow derived cells (BMDCs) in their capacity to repair and contribute to neo-vascularization following CR. Using high-resolution in vivo optical imaging we have studied, at single-cell resolution, the spatio-temporal response of BMDCs in normal brain following CR. We demonstrate that BMDCs are recruited specifically to the site of CR, in a radiation dose and temporal-spatial manner. We establish that BMDCs do not form endothelial cells but rather they differentiate predominantly into inflammatory cells and microglia. Most notably we provide evidence that more than 50% of the microglia in the irradiated region of the brain are not resident microglia but recruited from the bone marrow following CR. These results have invaluable therapeutic implications as BMDCs may be a primary therapeutic target to block acute and long-term inflammatory response following CR. Identifying the critical steps involved in the sustained recruitment and differentiation of BMDCs into microglia at the site of CR can provide new insights into the mechanisms of injury following CR offering potential therapeutic strategies to counteract the long-term adverse effects of CR

A Survey of Quality Engineering-ManagementJournals by Bibliometric Indicators

This paper analyses some of the most popular scientific journals in the Quality field from the point of view of three bibliometric indicators: the Hirsch (h) index for journals, the total number of citations and the h-spectrum. In particular, h-spectrum is a novel tool based on h, making it possible to (i) identify a reference profile of the typical authors of a journal; (ii) compare different journals; and (iii) provide a rough indication of their ‘bibliometric positioning' in the scientific community. Results of this analysis can be helpful for guiding potential authors and members of the scientific community in the Quality Engineering/Management area. A large amount of empirical data are presented and discusse

Analysis of the Hirsch index's operational properties

The h-index is a relatively recent bibliometric indicator for assessing the research output of scientists, based on the publications and the corresponding citations. Due to the original characteristics of easy calculation and immediate intuitive meaning, this indicator has become very popular in the scientific community. Also, it received some criticism essentially because of its ‘‘low" accuracy. The contribution of this paper is to provide a detailed analysis of the h-index, from the point of view of the indicator operational properties. This work can be helpful to better understand the peculiarities and limits of h and avoid its misuse. Finally, we suggest an additional indicator ðf Þ that complements h with the information related to the publication age, not compromising the original simplicity and immediacy of understandin

How important is the name in predicting false recognition for lookalike brands?

An underexploited role for psychology in trademark law is the testing of explicit or implicit judicial assumptions about consumer behavior. In this article we examine an assumption that is common across Commonwealth countries, namely, that similar packaging is unlikely to cause consumer confusion provided the brand names are dissimilar. We began by selecting branded products commonly found in supermarkets. For each existing brand we created 2 novel (fictitious) brands with highly similar packaging to the existing brand. One of these "lookalike" products had a similar name, the other a dissimilar name. Across 2 yes/no and 1 forced-choice experiments using photographs of the real and fictitious products we looked at false recognition rates. Contrary to the judicial assumption participants largely ignored the brand names when making their decisions based on memory. It was only when the pictures of the products were placed side-by-side (in the forced-choice task) that they paid the brand name any significant attention

How important is the name in predicting false recognition for lookalike brands?

An underexploited role for psychology in trademark law is the testing of explicit or implicit judicial assumptions about consumer behavior. In this article we examine an assumption that is common across Commonwealth countries, namely, that similar packaging is unlikely to cause consumer confusion provided the brand names are dissimilar. We began by selecting branded products commonly found in supermarkets. For each existing brand we created 2 novel (fictitious) brands with highly similar packaging to the existing brand. One of these "lookalike" products had a similar name, the other a dissimilar name. Across 2 yes/no and 1 forced-choice experiments using photographs of the real and fictitious products we looked at false recognition rates. Contrary to the judicial assumption participants largely ignored the brand names when making their decisions based on memory. It was only when the pictures of the products were placed side-by-side (in the forced-choice task) that they paid the brand name any significant attention

Brandname confusion: Subjective and objective measures of orthographic similarity

Determining brand name similarity is vital in areas of trademark registration and brand confusion. Students rated the orthographic (spelling) similarity of word pairs (Experiments 1, 2, and 4) and brand name pairs (Experiment 5). Similarity ratings were consistently higher when words shared beginnings rather than endings, whereas shared pronunciation of the stressed vowel had small and less consistent effects on ratings. In Experiment 3 a behavioral task confirmed the similarity of shared beginnings in lexical processing. Specifically, in a task requiring participants to decide whether 2 words presented in the clear (a probe and a later target) were the same or different, a masked prime word preceding the target shortened response latencies if it shared its initial 3 letters with the target. The ratings of students for word and brand name pairs were strongly predicted by metrics of orthographic similarity from the visual word identification literature based on the number of shared letters and their relative positions. The results indicate a potential use for orthographic metrics in brand name registration and trademark law

A Time Series of Water Column Distributions and Sinking Particle Flux of Pseudo-Nitzschia and Domoic Acid in the Santa Barbara Basin, California

Water column bulk Pseudo-nitzschia abundance and the dissolved and particulate domoic acid (DA) concentrations were measured in the Santa Barbara Basin (SBB), California from 2009–2013 and compared to bulk Pseudo-nitzschia cell abundance and DA concentrations and fluxes in sediment traps moored at 147 m and 509 m. Pseudo-nitzschia abundance throughout the study period was spatially and temporally heterogeneous (L−1 to 3.8 × 106 cells L−1 , avg. 2 × 105 ± 5 × 105 cells L−1 ) and did not correspond with upwelling conditions or the total DA (tDA) concentration, which was also spatially and temporally diverse (1000 cells L−1 and tDA = 200 ng L−1 ) measured as deep as 150 m. Our results highlight that dDA should not be ignored when examining bloom toxicity. Although water column abundance and pDA concentrations were poorly correlated with sediment trap Pseudo-nitzschia abundance and fluxes, DA toxicity is likely associated with senescent blooms that rapidly sink to the seafloor, adding another potential source of DA to benthic organisms

The citation triad: an overview of a scientist's publication output based on Ferrers diagrams

In a recent work by Anderson, Hankin, and Killworth (2008), Ferrers diagrams and Durfee squares are used to represent the scientific output of a scientist and construct a new h-based bibliometric indicator, the tapered h-index (hT). In the first part of this paper we examine hT, identifying its main drawbacks and weaknesses: an arbitrary scoring system and an illusory increase in discrimination power compared to h. Subsequently,wepropose a new bibliometric tool, the citation triad (CT), that better exploits the information contained in a Ferrers diagram, giving a synthetic overview of a scientist's publication output. The advantages of this new approach are discussed in detail. Argument is supported by several examples based on empirical dat