A failsafe analysis using NASTRAN's piecewise linear analysis and a nine node linear crack element

A two-dimensional crack element was implemented into NASTRAN as a user dummy element and used to study failsafe characteristics of the C5A fuselage. The element is formulated from Reitsner's functional requiring that it satisfy compatability with the linear boundary displacement elements in NASTRAN. Its accuracy is demonstrated by analyzing for the stress intensity factors of two simple crack configurations for which there are classic solutions

Examination of accelerated first order methods for aircraft flight path optimization

Accelerated first order methods for aircraft flight path optimizatio

NASTRAN used in a production environment

A finite element analysis procedure built around the NASTRAN system is assessed. A number of support programs that were either written or modified to interface with NASTRAN and some improvements that were made to NASTRAN itself are noted. Some typical models are analyzed and an actual schedule is followed for constructing and analyzing the models to support a large design program

Fault Slip and Exhumation History of the Willard Thrust Sheet, Sevier Fold‐Thrust Belt, Utah: Relations to Wedge Propagation, Hinterland Uplift, and Foreland Basin Sedimentation

Zircon (U‐Th)/He (ZHe) and zircon fission track thermochronometric data for 47 samples spanning the areally extensive Willard thrust sheet within the western part of the Sevier fold‐thrust belt record enhanced cooling and exhumation during major thrust slip spanning approximately 125–90 Ma. ZHe and zircon fission track age‐paleodepth patterns along structural transects and age‐distance relations along stratigraphic‐parallel traverses, combined with thermo‐kinematic modeling, constrain the fault slip history, with estimated slip rates of ~1 km/Myr from 125 to 105 Ma, increasing to ~3 km/Myr from 105 to 92 Ma, and then decreasing as major slip was transferred onto eastern thrusts. Exhumation was concentrated during motion up thrust ramps with estimated erosion rates of ~0.1 to 0.3 km/Myr. Local cooling ages of approximately 160–150 Ma may record a period of regional erosion, or alternatively an early phase of limited... (see full abstract in article)

Planning Activity Report for NDE of Adhesive Bonded Structures

Following a workshop held at the Rockwell International Science Center, Thousand Oaks, California in January, 1979, an ad hoc planning activity was undertaken to set forth a program plan to address the needs in NDE for adhesive bonded structures. The objectives of the planning activity were to develop a program rationale and strategy, determine the existence of reasonable approaches, and to propose a detailed plan of action for review at the annual DARPA/AF meeting in September, 1979. The plan encompasses the basic elements of an accept/reject methodology based on fracture mechanics, expected developments of valid flaw growth models, stress analysis, and non-destructive measurement techniques. A central issue is the prospect for determining a valid non-destructive measure of strength for the bonded joint as might be reflected in the tendency for preexistent flaws to propagate under environmental loads

K-causality and degenerate spacetimes

The causal relation $K^+$ was introduced by Sorkin and Woolgar to extend the standard causal analysis of $C^2$ spacetimes to those that are only $C^0$. Most of their results also hold true in the case of spacetimes with degeneracies. In this paper we seek to examine $K^+$ explicitly in the case of Lorentzian topology changing Morse spacetimes containing isolated degeneracies. We first demonstrate some interesting features of this relation in globally Lorentzian spacetimes. In particular, we show that $K^+$ is robust and that it coincides with the Seifert relation when the spacetime is stably causal. Moreover, the Hawking and Sachs characterisation of causal continuity translates into a natural expression in terms of $K^+$ for general spacetimes. We then examine $K^+$ in topology changing Morse spacetimes both with and without the degeneracies and find further characterisations of causal continuity.Comment: Latex, 23 pages, 4 figure

Low self-control promotes the willingness to sacrifice in close relationships

Although previous theories and research have suggested that human behavior is automatically driven by selfish impulses (e.g., vengeance rather than forgiveness), the present research tested the hypothesis that in close relationships, people's impulsive inclination is to be prosocial and to sacrifice for their partner-to pursue the interests of the partner or of the relationship at some costs for the self. Results from four studies demonstrated that people with low self-control, relative to those with high self-control, reported greater willingness to sacrifice for their close others. Furthermore, Study 4 demonstrated that communal orientation was more strongly associated with sacrifice among participants with low self-control than participants with high self-control. This moderational pattern supports the hypothesis that communal orientation functions as a default approach to sacrifice in the context of close relationships. Taken together, these findings suggest that under certain crucial conditions in close relationships, gut-level impulses are more likely than deliberative considerations to promote prorelationship behavior. © The Author(s) 2013

Cabozantinib in hepatocellular carcinoma: results of a phase 2 placebo-controlled randomized discontinuation study.

BackgroundCabozantinib, an orally bioavailable inhibitor of tyrosine kinases including MET, AXL, and VEGF receptors, was assessed in patients with hepatocellular carcinoma (HCC) as part of a phase 2 randomized discontinuation trial with nine tumor-type cohorts.Patients and methodsEligible patients had Child-Pugh A liver function and ≤1 prior systemic anticancer regimen, completed ≥4 weeks before study entry. The cabozantinib starting dose was 100 mg daily. After an initial 12-week cabozantinib treatment period, patients with stable disease (SD) per Response Evaluation Criteria in Solid Tumors (RECIST) version 1.0 were randomized to cabozantinib or placebo. The primary endpoint of the lead-in stage was objective response rate (ORR) at week 12, and the primary endpoint of the randomized stage was progression-free survival (PFS).ResultsAmong the 41 HCC patients enrolled, the week 12 ORR was 5%, with 2 patients achieving a confirmed partial response (PR). The week 12 disease control rate (PR or SD) was 66% (Asian subgroup: 73%). Of patients with ≥1 post-baseline scan, 78% had tumor regression, with no apparent relationship to prior sorafenib therapy. Alpha-fetoprotein (AFP) response (>50% reduction from baseline) occurred in 9 of the 26 (35%) patients with elevated baseline AFP and ≥1 post-baseline measurement. Twenty-two patients with SD at week 12 were randomized. Median PFS after randomization was 2.5 months with cabozantinib and 1.4 months with placebo, although this difference was not statistically significant. Median PFS and overall survival from Day 1 in all patients were 5.2 and 11.5 months, respectively. The most common grade 3/4 adverse events, regardless of attribution, were diarrhea (20%), hand-foot syndrome (15%), and thrombocytopenia (15%). Dose reductions were utilized in 59% of patients.ConclusionsCabozantinib has clinical activity in HCC patients, including objective tumor responses, disease stabilization, and reductions in AFP. Adverse events were managed with dose reductions.Trial registration numberNCT00940225