Photoinitiated Thiol-Ene Reactions of Various 2,3-Unsaturated O-,C- S- and N-Glycosides – Scope and Limitations Study

The photoinitiated thiol-ene addition reaction is a highly stereo- and regioselective, and environmentally friendly reaction proceeding under mild conditions, hence it is ideally suited for the synthesis of carbohydrate mimetics. A comprehensive study on UV-light-induced reactions of 2,3- unsaturated O-, C-, S- and N-glycosides with various thiols was performed. The effect of experimental parameters and structural variations of the alkenes and thiols on the efficacy and regio- and stereoselectivity of the reactions was systematically studied and optimized. The type of anomeric heteroatom was found to profoundly affect the reactivity of 2,3-unsaturated sugars in the thiol-ene couplings. Hydrothiolation of 2,3-dideoxy O-glycosyl enosides efficiently produced the axially C2-S-substituted addition products with high to complete regioselectivity. Moderate efficacy and varying regio- and stereoselectivity were observed with 2,3- unsaturated N-glycosides and no addition occurred onto the endocyclic double bond of C-glycosides. Upon hydrothiolation of 2,3-unsaturated S-glycosides, the addition of thiyl radicals was followed by elimination of the thiyl aglycone resulting in 3-S-substituted glycals

E-sportolók mérése

Jelen munkában készítjük elő azt a tanulmányt, mely hivatott lesz majd eldönteni, hogy az általunk bevezetendő mérési módszer (esport-talent-search/BrainB 5-ös sorozat) eredményes lehet-e a jövő kiemelkedő e-sportolóinak korai felismerésében, felkutatásában. A jelen előkészítésben bemutatjuk a mérés alapötletét, a mérést végző, általunk kifejlesztett nyílt forráskódú szoftvert és a mérést végző e-sport-szakértők aggregált tapasztalatait. Viszont a mért adatok statisztikai feldolgozásával, a mérési módszer és az eredmények vizsgálatával nem foglalkozunk, hanem csak néhány esetben mért, nyers adatokat villantunk fel. &#x0D; &#x0D; ---&#x0D; &#x0D; Measuring Esport Athletes&#x0D; &#x0D; In this paper, we outline the concept of a future study in which we will analyse our methodology (esport-talent-search/BrainB series 5) for measuring esport talents. We introduce the idea behind our method and an open source software that can measure gamers. We summarize the experiences of athletes who tested our software. In this paper, we do not analyse our data statistically or evaluate the method and the results, but only show some raw data.&#x0D; &#x0D; Keywords: DEAC-Hackers, esport, cognitive abilities, human-computer interaction (HCI)</jats:p

Investigation of binding affinity of a broad array of L-fucosides with six fucose-specific lectins from bacterial and fungal origin

Series of multivalent α-L-fucoside containing glycoclusters and variously decorated L-fucosides were synthesized to find potential inhibitors of fucose-specific lectins and study the structure-binding affinity relationships. Tri- and tetravalent fucoclusters were built up using copper-mediated azide-alkyne click chemistry. Series of fucoside monomers and dimers were synthesized using various methods, namely glycosylation, azide-alkyne click reaction, photoinduced thiol-en addition and sulfation. The interactions of compounds with six fucolectins of bacterial or fungal origin were tested using hemagglutination inhibition assay. As a result, a tetravalent, α-L-fucose presenting glycocluster showed to be orders of magnitude better ligand than a simple monosaccharide for tested lectins in most cases, which can nominate it as a universal ligand for studied lectins. This compound was also able to inhibit adhesion of Pseudomonas aeruginosa cells to human epithelial bronchial cells. A trivalent fucocluster with protected amine functional group seems also to be a promising candidate to design glycoconjugates and chimeras

Photoinitiated Thiol-Ene Reactions of Various 2,3-Unsaturated O-, C- S- and N-Glycosides: scope and Limitations Study

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Investigation of the Binding Affinity of a Broad Array of l-Fucosides with Six Fucose-Specific Lectins of Bacterial and Fungal Origin

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E-sportolók mérése

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Comparative biocompatibility and antimicrobial studies of sorbic acid derivates

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