Spontaneous Supersymmetric Generation of an Indeterminate Mass Scale and a Possible Light Sterile Neutrino

If a global continuous symmetry of a supersymmetric field theory is spontaneously broken while preserving the supersymmetry, the resulting theory has a massless superfield. One of its two bosonic degrees of freedom is the familiar phase rotation of the usual massless Nambu-Goldstone boson, but the other is a scale transformation. An indeterminate mass scale is thus generated. In the fermion sector, a seesaw texture appears which may be suitable for a possible light sterile neutrino. This feature persists even after the gauging of the continuous symmetry or the breaking of the supersymmetry to resolve the aforementioned mass-scale ambiguity.Comment: 9 pages, expanded to include the discussion of a possible sterile neutrin

Large Scale Baryon Isocurvature Inhomogeneities

Big bang nucleosynthesis constraints on baryon isocurvature perturbations are determined. A simple model ignoring the effects of the scale of the perturbations is first reviewed. This model is then extended to test the claim that large amplitude perturbations will collapse, forming compact objects and preventing their baryons from contributing to the observed baryon density. It is found that baryon isocurvature perturbations are constrained to provide only a slight increase in the density of baryons in the universe over the standard homogeneous model. In particular it is found that models which rely on power laws and the random phase approximation for the power spectrum are incompatible with big bang nucleosynthesis unless an {\em ad hoc}, small scale cutoff is included.Comment: 11pages + 8figures, LaTeX (2.09), postscript figures available via anonymous ftp from oddjob.uchicago.edu:/ftp/ibbn/fig?.ps where ?=1-8 or via email from [email protected], Fermilab-Pub-94/???-A and UMN-TH-1307/9

Testing Bekenstein's Relativistic MOND gravity with Lensing Data

We propose to use multiple-imaged gravitational lenses to set limits on gravity theories without dark matter, specificly TeVeS (Bekenstein 2004), a theory which is consistent with fundamental relativistic principles and the phenomenology of MOdified Newtonian Dynamics (MOND) theory. After setting the framework for lensing and cosmology, we derive analytically the deflection angle for the point lens and the Hernquist galaxy profile, and fit galaxy-quasar lenses in the CASTLES sample. We do this with three methods, fitting the observed Einstein ring sizes, the image positions, or the flux ratios. In all cases we consistently find that stars in galaxies in MOND/TeVeS provide adequate lensing. Bekenstein's toy $\mu$ function provides more efficient lensing than the standard MOND $\mu$ function. But for a handful of lenses [indicated in Table 2,3, fig 16] a good fit would require a lens mass orders of magnitude larger/smaller than the stellar mass derived from luminosity unless the modification function $\mu$ and modification scale $a_0$ for the universal gravity were allowed to be very different from what spiral galaxy rotation curves normally imply. We discuss the limitation of present data and summarize constraints on the MOND $\mu$ function. We also show that the simplest TeVeS "minimal-matter" cosmology, a baryonic universe with a cosmological constant, can fit the distance-redshift relation from the supernova data, but underpredicts the sound horizon size at the last scattering. We conclude that lensing is a promising approach to differentiate laws of gravity (see also astro-ph/0512425).Comment: reduced to 17p, 16 figs, discussed cosmology and constraints on mu-function, MNRAS accepte

Kinetics of Surfactant Adsorption at Fluid-Fluid Interfaces: Surfactant Mixtures

The adsorption at the interface between an aqueous solution of several surface-active agents and another fluid (air or oil) phase is addressed theoretically. We derive the kinetic equations from a variation of the interfacial free energy, solve them numerically and provide an analytic solution for the simple case of a linear adsorption isotherm. Calculating asymptotic solutions analytically, we find the characteristic time scales of the adsorption process and observe the behavior of the system at various temporal stages. In particular, we relate the kinetic behavior of the mixture to the properties of its individual constituents and find good agreement with experiments. In the case of kinetically limited adsorption, the mixture kinetics is found to be considerably different from that of the single-surfactant solutions because of strong coupling between the species.Comment: 19 pages, 7 figures, to be published in Langmui

A creature with a hundred waggly tails: intrinsically disordered proteins in the ribosome

This article is made available for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.Intrinsic disorder (i.e., lack of a unique 3-D structure) is a common phenomenon, and many biologically active proteins are disordered as a whole, or contain long disordered regions. These intrinsically disordered proteins/regions constitute a significant part of all proteomes, and their functional repertoire is complementary to functions of ordered proteins. In fact, intrinsic disorder represents an important driving force for many specific functions. An illustrative example of such disorder-centric functional class is RNA-binding proteins. In this study, we present the results of comprehensive bioinformatics analyses of the abundance and roles of intrinsic disorder in 3,411 ribosomal proteins from 32 species. We show that many ribosomal proteins are intrinsically disordered or hybrid proteins that contain ordered and disordered domains. Predicted globular domains of many ribosomal proteins contain noticeable regions of intrinsic disorder. We also show that disorder in ribosomal proteins has different characteristics compared to other proteins that interact with RNA and DNA including overall abundance, evolutionary conservation, and involvement in protein–protein interactions. Furthermore, intrinsic disorder is not only abundant in the ribosomal proteins, but we demonstrate that it is absolutely necessary for their various functions

Targeting telomerase for cancer therapeutics

One of the hallmarks of advanced malignancies is continuous cell growth and this almost universally correlates with the reactivation of telomerase. Although there is still much we do not understand about the regulation of telomerase, it remains a very attractive and novel target for cancer therapeutics. Several clinical trials have been initiated, and in this review we highlight some of the most promising approaches and conclude by speculating on the role of telomerase in cancer stem cells

Should Tort Damages Be Multiplied?

The notion that damages should be multiplied by the reciprocal of the probability of punishment is one of the basic lessons of the law and economics literature. However, the simple l/p multiplier turns out be inapplicable in the civil damages setting. The multiplier that brings about first-best deterrence must be chosen by striking a balance between the supply of lawsuits and the need to internalize costs. Moreover, given the costs of litigation, a multiplier that minimizes overall social costs (in contrast to achieving first-best deterrence) may need to be set at a level that effectively bars many claims. This article derives optimal damage multipliers for a costly civil litigation system and examines the conflicting implications of deterrence and social cost minimization as objectives in the design of an optimal multiplier. An empirical application suggests that the first-best deterrence multiplier for the tort system is roughly equal to two

RNA Sequencing Reveals Novel Transcripts from Sympathetic Stellate Ganglia During Cardiac Sympathetic Hyperactivity.

Cardiovascular disease is the most prevalent age-related illness worldwide, causing approximately 15 million deaths every year. Hypertension is central in determining cardiovascular risk and is a strong predictive indicator of morbidity and mortality; however, there remains an unmet clinical need for disease-modifying and prophylactic interventions. Enhanced sympathetic activity is a well-established contributor to the pathophysiology of hypertension, however the cellular and molecular changes that increase sympathetic neurotransmission are not known. The aim of this study was to identify key changes in the transcriptome in normotensive and spontaneously hypertensive rats. We validated 15 of our top-scoring genes using qRT-PCR, and network and enrichment analyses suggest that glutamatergic signalling plays a key role in modulating Ca2+ balance within these ganglia. Additionally, phosphodiesterase activity was found to be altered in stellates obtained from the hypertensive rat, suggesting that impaired cyclic nucleotide signalling may contribute to disturbed Ca2+ homeostasis and sympathetic hyperactivity in hypertension. We have also confirmed the presence of these transcripts in human donor stellate samples, suggesting that key genes coupled to neurotransmission are conserved. The data described here may provide novel targets for future interventions aimed at treating sympathetic hyperactivity associated with cardiovascular disease and other dysautonomias

Investigating the source of Planck-detected AME: high resolution observations at 15 GHz

The Planck 28.5 GHz maps were searched for potential Anomalous Microwave Emission (AME) regions on the scale of $\sim3^{\circ}$ or smaller, and several new regions of interest were selected. Ancillary data at both lower and higher frequencies were used to construct spectral energy distributions (SEDs), which seem to confirm an excess consistent with spinning dust models. Here we present higher resolution observations of two of these new regions with the Arcminute Microkelvin Imager Small Array (AMI SA) between 14 and 18 GHz to test for the presence of a compact ($\sim$10 arcmin or smaller) component. For AME-G107.1+5.2, dominated by the {\sc Hii} region S140, we find evidence for the characteristic rising spectrum associated with the either the spinning dust mechanism for AME or an ultra/hyper-compact \textsc{Hii} region across the AMI frequency band, however for AME-G173.6+2.8 we find no evidence for AME on scales of $\sim 2-10$ arcmin.Comment: 13 pages, 8 figures, 4 tables. Submitted to Advances in Astronomy AME Special Issu