86 research outputs found

    Equivalence between definitions of the gravitational deflection angle of light for a stationary spacetime

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    The Gibbons-Werner-Ono-Ishihara-Asada method for gravitational lensing in a stationary spacetime has been recently reexamined [Huang and Cao, arXiv:2306.04145], in which the gravitational deflection angle of light based on the Gauss-Bonnet theorem can be rewritten as a line integral of two functions HH and TT. The present paper proves that the Huang-Cao line integral definition and the Ono-Ishihara-Asada one [Phys. Rev. D 96, 104037 (2017)] are equivalent to each other, whatever asymptotic regions are. A remark is also made concerning the direction of a light ray in a practical use of these definitions.Comment: 4 pages, 1 figure, text improved, accepted for PR

    A Study on Optimal Design of Optical Devices Utilizing Coupled Mode Theory and Machine Learning

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    We propose a new design approach to improve the computational efficiency of an optimal design of optical waveguide devices utilizing coupled mode theory (CMT) and a neural network (NN). Recently, the NN has begun to be used for efficient optimal design of optical devices. In this paper, the eigenmode analysis required in the CMT is skipped by using the NN, and optimization with an evolutionary algorithm can be efficiently carried out. To verify usefulness of our approach, optimal design examples of a wavelength insensitive 3dB coupler, a 1 : 2 power splitter, and a wavelength demultiplexer are shown and their transmission properties obtained by the CMT with the NN (NN-CMT) are verified by comparing with those calculated by a finite element beam propagation method (FE-BPM)

    Iroquois homeobox 3 regulates odontoblast proliferation and differentiation mediated by Wnt5a expression

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    Iroquois homeobox (Irx) genes are TALE-class homeobox genes that are evolutionarily conserved across species and have multiple critical cellular functions in fundamental tissue development processes. Previous studies have shown that Irxs genes are expressed during tooth development. However, the precise roles of genes in teeth remain unclear. Here, we demonstrated for the first time that Irx3 is an essential molecule for the proliferation and differentiation of odontoblasts. Using cDNA synthesized from postnatal day 1 (P1) tooth germs, we examined the expression of all Irx genes (Irx1-Irx6) by RT-PCR and found that all genes except Irx4 were expressed in the tooth tissue. Irx1-Irx3 a were expressed in the dental epithelial cell line M3H1 cells, while Irx3 and Irx5 were expressed in the dental mesenchymal cell line mDP cells. Only Irx3 was expressed in both undifferentiated cell lines. Immunostaining also revealed the presence of IRX3 in the dental epithelial cells and mesenchymal condensation. Inhibition of endogenous Irx3 by siRNA blocks the proliferation and differentiation of mDP cells. Wnt3a, Wnt5a, and Bmp4 are factors involved in odontoblast differentiation and were highly expressed in mDP cells by quantitative PCR analysis. Interestingly, the expression of Wnt5a (but not Wnt3a or Bmp4) was suppressed by Irx3 siRNA. These results suggest that Irx3 plays an essential role in part through the regulation of Wnt5a expression during odontoblast proliferation and differentiation
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