Asymptotics for statistical treatment rules

This paper develops asymptotic optimality theory for statistical treatment rules in smooth parametric and semiparametric models. Manski (2000, 2002, 2004) and Dehejia (2005) have argued that the problem of choosing treatments to maximize social welfare is distinct from the point estimation and hypothesis testing problems usually considered in the treatment effects literature, and advocate formal analysis of decision procedures that map empirical data into treatment choices. We develop large-sample approximations to statistical treatment assignment problems in both randomized experiments and observational data settings in which treatment effects are identified. We derive a local asymptotic minmax regret bound on social welfare, and a local asymptotic risk bound for a two-point loss function. We show that certain natural treatment assignment rules attain these bounds.treatment effect; statistical decision theory; minmax regret; treatment assignment rules

Impossibility Results for Nondifferentiable Functionals

We examine challenges to estimation and inference when the objects of interest are nondifferentiable functionals of the underlying data distribution. This situation arises in a number of applications of bounds analysis and moment inequality models, and in recent work on estimating optimal dynamic treatment regimes. Drawing on earlier work relating differentiability to the existence of unbiased and regular estimators, we show that if the target object is not continuously differentiable in the parameters of the data distribution, there exist no locally asymptotically unbiased estimators and no regular estimators. This places strong limits on estimators, bias correction methods, and inference procedures.bounds analysis; moment inequality models; treatment effects; limits of experiments

Adaptive Experimental Design Using the Propensity Score

Many social experiments are run in multiple waves, or are replications of earlier social experiments. In principle, the sampling design can be modified in later stages or replications to allow for more efficient estimation of causal effects. We consider the design of a two-stage experiment for estimating an average treatment effect, when covariate information is available for experimental subjects. We use data from the first stage to choose a conditional treatment assignment rule for units in the second stage of the experiment. This amounts to choosing the propensity score, the conditional probability of treatment given covariates. We propose to select the propensity score to minimize the asymptotic variance bound for estimating the average treatment effect. Our procedure can be implemented simply using standard statistical software and has attractive large-sample properties.

Adaptive Experimental Design Using the Propensity Score

Many social experiments are run in multiple waves, or are replications of earlier social experiments. In principle, the sampling design can be modified in later stages or replications to allow for more efficient estimation of causal effects. We consider the design of a two-stage experiment for estimating an average treatment effect, when covariate information is available for experimental subjects. We use data from the first stage to choose a conditional treatment assignment rule for units in the second stage of the experiment. This amounts to choosing the propensity score, the conditional probability of treatment given covariates. We propose to select the propensity score to minimize the asymptotic variance bound for estimating the average treatment effect. Our procedure can be implemented simply using standard statistical software and has attractive large-sample properties.experimental design, propensity score, efficiency bound

Efficient Estimation of Average Treatment Effects Using the Estimated Propensity Score

We are interested in estimating the average effect of a binary treatment on a scalar outcome. If assignment to the treatment is independent of the potential outcomes given pretreatment variables, biases associated with simple treatment-control average comparisons can be removed by adjusting for differences in the pre-treatment variables. Rosenbaum and Rubin (1983, 1984) show that adjusting solely for differences between treated and control units in a scalar function of the pre-treatment, the propensity score, also removes the entire bias associated with differences in pre-treatment variables. Thus it is possible to obtain unbiased estimates of the treatment effect without conditioning on a possibly high-dimensional vector of pre-treatment variables. Although adjusting for the propensity score removes all the bias, this can come at the expense of efficiency. We show that weighting with the inverse of a nonparametric estimate of the propensity score, rather than the true propensity score, leads to efficient estimates of the various average treatment effects. This result holds whether the pre-treatment variables have discrete or continuous distributions. We provide intuition for this result in a number of ways. First we show that with discrete covariates, exact adjustment for the estimated propensity score is identical to adjustment for the pre-treatment variables. Second, we show that weighting by the inverse of the estimated propensity score can be interpreted as an empirical likelihood estimator that efficiently incorporates the information about the propensity score. Finally, we make a connection to results to other results on efficient estimation through weighting in the context of variable probability sampling.

Two cases of retrobulbar meningioma excised by skull base approaches

We present two cases of orbital meningioma which were totally excised by a neurosurgical and craniomaxillofacial team using skull base approaches

Asymptotics for statistical treatment rules

This paper develops asymptotic optimality theory for statistical treatment rules in smooth parametric and semiparametric models. Manski (2000, 2002, 2004) and Dehejia (2005) have argued that the problem of choosing treatments to maximize social welfare is distinct from the point estimation and hypothesis testing problems usually considered in the treatment effects literature, and advocate formal analysis of decision procedures that map empirical data into treatment choices. We develop large-sample approximations to statistical treatment assignment problems in both randomized experiments and observational data settings in which treatment effects are identified. We derive a local asymptotic minmax regret bound on social welfare, and a local asymptotic risk bound for a two-point loss function. We show that certain natural treatment assignment rules attain these bounds