Experiment K-6-12. Morphometric studies of atrial or granules and hepatocytes. Part 1: Morphometric study of the liver; Part 2: The atrial granular accumulations

The livers of flight, F, rats from the Cosmos 1887 mission were markedly paler and heavier than those of the synchronous, S, and vivarium, V, controls. In the F group, microscopic study revealed extensive hepatocytic intracytoplasmic vacuolization which was moderate in the S and minimal in the V groups. The vacuoles were not sudanophilic and therefore were regarded as glycogenic in origin. To obtain objective data concerning the extent of the vacuolization, livers were examined by computer assisted morphometry. Measurements of profile area and perimeter of the hepatocyte nuclei and vacuoles were evaluated according to stereological principles. Results indicated that the volume density of the nuclei was less in the F group than in the S(p equal less than 0.0002) and V(p equal less than 0.001) groups. Mean volume of individual nuclei did not differ. Volume density of the vacuoles was greater in the F than in the V group (p equal less than 0.02) while their mean diameter was less (p equal less than 0.05). To ascertain the relationship between increase in liver weight of the flight animals and the results of this study, an assumption was made that the specific gravity of the vacuolar contents was similar to the other extranuclear components of the hepatocyte. On that basis, calculations showed that the elevated vacuolar volume density in the flight group did not cause the increased liver weight in those animals, but that the non-nuclear, non-vacuolar parenchymal compartment did contribute significantly. Factors that may have played a causal role in liver weight and vacuolar compartment increases are discussed

Vascular uptake of rehydration fluids in hypohydrated men at rest and exercise

The purpose of this study was to formulate and to evaluate rehydration drinks, which would restore total body water and plasma volume (PV), for astronauts to consume before and during extravehicular activity, a few hours before reentry, and immediately after landing. In the first experiment (rest, sitting), five healthy men (23-41 yr), previously dehydrated for 24 hr., drank six (1a, 2, 4, 5, 6, 7) fluid formulations (one each at weekly intervals) and then sat for 70 min. Pre-test PV were measured with Evans blue dye and changes in PV were calculated with the hematocrit-hemoglobin transformation equation. This rest experiment simulated hypohydrated astronauts preparing for reentry. The second experiment (exercise, supine) followed the same protocol except four healthy men (30-46 yr) worked for 70 min. in the supine position on a cycle ergometer at a mean load of 71+/-1 percent of their peak aerobic work capacity. This exercise experiment simulated conditions for astronauts with reduced total body water engaging in extravehicular activity

Hemodynamic and ADH responses to central blood volume shifts in cardiac-denervated humans

Hemodynamic responses and antidiuretic hormone (ADH) were measured during body position changes designed to induce blood volume shifts in ten cardiac transplant recipients to assess the contribution of cardiac and vascular volume receptors in the control of ADH secretion. Each subject underwent 15 min of a control period in the seated posture, then assumed a lying posture for 30 min at 6 deg head down tilt (HDT) followed by 20 min of seated recovery. Venous blood samples and cardiac dimensions (echocardiography) were taken at 0 and 15 min before HDT, 5, 15, and 30 min of HDT, and 5, 15, and 30 min of seated recovery. Blood samples were analyzed for hematocrit, plasma osmolality, plasma renin activity (PRA), and ADH. Resting plasma volume (PV) was measured by Evans blue dye and percent changes in PV during posture changes were calculated from changes in hematocrit. Heart rate (HR) and blood pressure (BP) were recorded every 2 min. Results indicate that cardiac volume receptors are not the only mechanism for the control of ADH release during acute blood volume shifts in man

Spanning Properties of Theta-Theta Graphs

We study the spanning properties of Theta-Theta graphs. Similar in spirit with the Yao-Yao graphs, Theta-Theta graphs partition the space around each vertex into a set of k cones, for some fixed integer k > 1, and select at most one edge per cone. The difference is in the way edges are selected. Yao-Yao graphs select an edge of minimum length, whereas Theta-Theta graphs select an edge of minimum orthogonal projection onto the cone bisector. It has been established that the Yao-Yao graphs with parameter k = 6k' have spanning ratio 11.67, for k' >= 6. In this paper we establish a first spanning ratio of $7.82$ for Theta-Theta graphs, for the same values of $k$. We also extend the class of Theta-Theta spanners with parameter 6k', and establish a spanning ratio of $16.76$ for k' >= 5. We surmise that these stronger results are mainly due to a tighter analysis in this paper, rather than Theta-Theta being superior to Yao-Yao as a spanner. We also show that the spanning ratio of Theta-Theta graphs decreases to 4.64 as k' increases to 8. These are the first results on the spanning properties of Theta-Theta graphs.Comment: 20 pages, 6 figures, 3 table

Quantum walks of correlated photon pairs in two-dimensional waveguide arrays

We demonstrate quantum walks of correlated photons in a 2D network of directly laser written waveguides coupled in a 'swiss cross' arrangement. The correlated detection events show high-visibility quantum interference and unique composite behaviour: strong correlation and independence of the quantum walkers, between and within the planes of the cross. Violations of a classically defined inequality, for photons injected in the same plane and in orthogonal planes, reveal non-classical behaviour in a non-planar structure.Comment: 5 pages, 5 figure

Conceptual analysis: A Social neuroscience approach to interpersonal interaction in the context of disruption and disorganization of attachment (NAMDA)

Humans are strongly dependent upon social resources for allostasis and emotion regulation. This applies especially to early childhood because humans-as an altricial species-have a prolonged period of dependency on support and input from caregivers who typically act as sources of co-regulation. Accordingly, attachment theory proposes that the history and quality of early interactions with primary caregivers shape children's internal working models of attachment. In turn, these attachment models guide behavior, initially with the set goal of maintaining proximity to caregivers but eventually paving the way to more generalized mental representations of self and others. Mounting evidence in non-clinical populations suggests that these mental representations coincide with differential patterns of neural structure, function, and connectivity in a range of brain regions previously associated with emotional and cognitive capacities. What is currently lacking, however, is an evidence-based account of how early adverse attachment-related experiences and/or the emergence of attachment disorganization impact the developing brain. While work on early childhood adversities offers important insights, we propose that how these events become biologically embedded crucially hinges on the context of the child-caregiver attachment relationships in which the events take place. Our selective review distinguishes between direct social neuroscience research on disorganized attachment and indirect maltreatment-related research, converging on aberrant functioning in neurobiological systems subserving aversion, approach, emotion regulation, and mental state processing in the wake of severe attachment disruption. To account for heterogeneity of findings, we propose two distinct neurobiological phenotypes characterized by hyper- and hypo-arousal primarily deriving from the caregiver serving either as a threatening or as an insufficient source of co-regulation, respectively

Detecting the Neutrino Mass Hierarchy with a Supernova at IceCube

IceCube, a future km^3 antarctic ice Cherenkov neutrino telescope, is highly sensitive to a galactic supernova (SN) neutrino burst. The Cherenkov light corresponding to the total energy deposited by the SN neutrinos in the ice can be measured relative to background fluctuations with a statistical precision much better than 1%. If the SN is viewed through the Earth, the matter effect on neutrino oscillations can change the signal by more than 5%, depending on the flavor-dependent source spectra and the neutrino mixing parameters. Therefore, IceCube together with another high-statistics experiment like Hyper-Kamiokande can detect the Earth effect, an observation that would identify specific neutrino mixing scenarios that are difficult to pin down with long-baseline experiments. In particular, the normal mass hierarchy can be clearly detected if the third mixing angle is not too small, sin^2 theta_13 < 10^-3. The small flavor-dependent differences of the SN neutrino fluxes and spectra that are found in state-of-the-art simulations suffice for this purpose. Although the absolute calibration uncertainty at IceCube may exceed 5%, the Earth effect would typically vary by a large amount over the duration of the SN signal, obviating the need for a precise calibration. Therefore, IceCube with its unique geographic location and expected longevity can play a decisive role as a "co-detector" to measure SN neutrino oscillations. It is also a powerful stand-alone SN detector that can verify the delayed-explosion scenario.Comment: 19 pages, 6 Figs, final version accepted by JCAP, some references adde

DEXA-Measured VAT Robustly Predicts Impaired Glucose Tolerance and Metabolic Syndrome in Obese Women

Abdominal visceral adiposity (VAT) has been shown to be an independent risk factor for metabolic and cardiovascular disease. Using enCORE analysis version 13.6 on a GE Lunar iDXA, a new fully automated analysis software to measure VAT, we determined the strength of associations between DEXA-derived VAT and other known indicators for diabetes and cardiovascular disease risk in Caucasian and African American obese women. We collected anthropometrics, vital signs, lipid profile, and DXA whole body composition scan for 229 subjects with BMI 30.0 – 49.9 kg/m2 & age 21 to 69 y. We then performed the non-parametric Spearman correlation analysis and found that in subjects overall, DEXA-VAT is positively associated with triglyceride, fasting glucose, fasting insulin, and HOMA-IR, and negatively associated with HDL. Among all anthropometric, body composition and cardiometabolic variables, DEXA-VAT was the most robust predictor of impaired glucose tolerance (IGT) and metabolic syndrome (MetSx) in binary regression analysis, even after adjusting for race. LASSO regression after adjusting for covariates that best predicted IGT and MetSx showed that HOMAIR and DEXA-VAT most significantly predicted IGT (p\u3c0.001, p\u3c0.001, respectively), and DEXA-VAT most significantly predicted MetSx (p\u3c0.001). These observations have implications for VAT associated risk in diabetes and cardiovascular disease

Neutrino Coherent Scattering Rates at Direct Dark Matter Detectors

Neutrino-induced recoil events may constitute a background to direct dark matter searches, particularly for those detectors that strive to reach the ton-scale and beyond. This paper discusses the expected neutrino-induced background spectrum due to several of the most important sources, including solar, atmospheric, and diffuse supernova neutrinos. The largest rate arises from $^8$B produced solar neutrinos, providing upwards of $\sim 10^3$ events per ton-year over all recoil energies for the heaviest nuclear targets. However the majority of these $^8$B events are expected to be below the recoil threshold of modern detectors. The remaining neutrino sources are found to constitute a background to the WIMP-induced recoil rate only if the WIMP-nucleon cross section is less than $10^{-12}$ pb. Finally the sensitivity to diffuse supernova neutrino flux for non-electron neutrino flavors is discussed, and projected flux limits are compared with existing flux limits

Gender differences in endocrine responses to posture and 7 days of 6 deg head down bed rest

Endocrine regulation of fluids and electrolytes during seven days of 6 deg head down bed rest (HDBR) was compared in male (n = 8) and, for the first time, female (n = 8) volunteers. The subjects' responses to quiet standing for 2 hr before and after HDBR were also tested. In both sexes, diuresis and natriuresis were evident during the first 2-3 days of HDBR, resulting in a marked increase in the urinary Na/K ratio and significant Na retention on reambulation. After the first day of HDBR, plasma renin activity (PRA) was increased relative to aldosterone, plasma volume was decreased, and the renal response to aldosterone appeared to be appropriate. Circulating levels of arginine vasopressin (AVP), cortisol, and ACTH were unchanged during HDBR. Plasma testosterone decreased slightly on day 2 of HDBR in males. The ratio of AM ACTH to cortisol was lower in females than in males because ACTH was lower in females. Urinary cortisol increased and remained elevated throughout the HDBR in males only. There were no gender differences in the responses to 7 day HDBR, except those in the pituitary-adrenal system; those differences appeared unrelated to the postural change. The provocative cardiovascular test of quiet standing before and after bed rest revealed both sex differences and effects of HDBR. There were significant sex differences in cardiovascular responses to standing, before and after HDBR. Females had greater PRA and aldosterone responses to standing before bedrest and larger aldosterone responses to standing after HDBR than males. Cardiovascular responses to standing before and after bedrest differed markedly: arterial pressure and heart rates increased with standing before HDBR, by contrast, arterial pressure decreased, with greater increases in heart rates after HDBR. In both sexes, all hormonal responses to standing were greater after HDBR. The results show clearly that similar responses to standing as well as to HDBR occur in both sexes, but that females exhibit greater PRA and aldosterone responses than males