Coupled Eulerian-Lagrangian Debris Flow Model with Flexible Barrier

Natural hazards such as large debris flow events can have catastrophic effects on the environment and critical infrastructure, posing a significant threat to human life. Debris flows often exhibit high velocity, high-pressure discharges due to their bulk volume, and the capacity to transport considerable volumes of large rocks, boulders, and woody debris. Although debris flow run-out simulations are commonly performed using hydraulic modelling software, these environments are seldom capable of assessing the interaction between the debris fluid, transported material, and protective structures. In this research, large deformation numerical models are calibrated using input parameters from hydraulic modelling software. Due to the computational cost of the large deformation models involving fluid-solid-structure simulation with flexible net barriers, an equivalent stiffness method is implemented to provide comparable performance through a membrane structure. The Coupled Eulerian-Lagrangian Finite Element method is used to model the impact forces of rocky boulders on the membrane, exhibiting damage characteristics consistent with flexible ring-net protective structures. The Coupled Eulerian-Lagrangian model results highlight the performance of the simplified membrane, as shown through a benchmark simulation of debris flow with boulders

Simulation of tumor ablation in hyperthermia cancer treatment: A parametric study

A holistic simulation framework is established on magnetic hyperthermia modeling to solve the treatment process of tumor, which is surrounded by a healthy tissue block. The interstitial tissue fluid, MNP distribution, temperature profile, and nanofluids are involved in the simulation. Study evaluates the cancer treatment efficacy by cumulative-equivalent-minutes-at-43 centigrade (CEM43), a widely accepted thermal dose coming from the cell death curve. Results are separated into the conditions of with or without gravity effect in the computational domain, where two baseline case are investigated and compared. An optimal treatment time 46.55 min happens in the baseline case without gravity, but the situation deteriorates with gravity effect where the time for totally killing tumor cells prolongs 36.11% and meanwhile causing 21.32% ablation in healthy tissue. For the cases without gravity, parameter study of Lewis number and Heat source number are conducted and the variation of optimal treatment time are both fitting to the inverse functions. For the case considering the gravity, parameters Buoyancy ratio and Darcy ratio are investigated and their influence on totally killing tumor cells and the injury on healthy tissue are matching with the parabolic functions. The results are beneficial to the prediction of various conditions, and provides useful guide to the magnetic hyperthermia treatment

Cooling and Water Production in a Hybrid Desiccant M-Cycle Evaporative Cooling System with HDH Desalination: A Comparison of Operational Modes

In this paper, the cooling and freshwater generation performance of a novel hybrid configuration of a solid desiccant-based M-cycle cooling system (SDM) combined with a humidification–dehumidification (HDH) desalination unit is analysed and compared in three operational modes: ventilation, recirculation, and half recirculation. The HDH unit in this system recycles the moist waste air sourced from the M-cycle cooler and rotary desiccant wheel of the SDM system to enhance water production. A mathematical model was established and solved using TRNSYS and EES software. The results of this study indicate that the recirculation mode exhibited superior cooling performance compared to the other two modes, producing up to 7.91 kW of cooling load and maintaining a supply air temperature below 20.85 °C and humidity of 12.72 g/kg under various ambient conditions. All the operational modes showed similar water production rates of around 52.74 kg/h, 52.43 kg/h, and 52.14 kg/h for the recirculation, half-recirculation and ventilation modes, respectively, across a range of operating temperatures. The recirculation mode also exhibited a higher COP compared to the other modes, as the environmental temperature and relative humidity were above 35 °C and 50%. However, it should be noted that the implementation of the recirculation mode resulted in a higher water consumption rate, with a maximum value of 5.52 kg/h when the inlet air reached 45 °C, which partially offset the benefits of this mode

Coupled Eulerian-Lagrangian Debris Flow Model with Flexible Barrier

Natural hazards such as large debris flow events can have catastrophic effects on the environment and critical infrastructure, posing a significant threat to human life. Debris flows often exhibit high velocity, high-pressure discharges due to their bulk volume, and the capacity to transport considerable volumes of large rocks, boulders, and woody debris. Although debris flow run-out simulations are commonly performed using hydraulic modelling software, these environments are seldom capable of assessing the interaction between the debris fluid, transported material, and protective structures. In this research, large deformation numerical models are calibrated using input parameters from hydraulic modelling software. Due to the computational cost of the large deformation models involving fluid-solid-structure simulation with flexible net barriers, an equivalent stiffness method is implemented to provide comparable performance through a membrane structure. The Coupled Eulerian-Lagrangian Finite Element method is used to model the impact forces of rocky boulders on the membrane, exhibiting damage characteristics consistent with flexible ring-net protective structures. The Coupled Eulerian-Lagrangian model results highlight the performance of the simplified membrane, as shown through a benchmark simulation of debris flow with boulders

On the magnetic nanoparticle injection strategy for hyperthermia treatment

We developed a dedicated computational framework by coupling the lattice-Boltzmann-method (LBM) modeling and the particle-swarm-optimization (PSO) algorithm to search optimal strategies of magnetic nanoparticle (MNP) injection for hyperthermia-based cancer treatment. Two simplified tumor models were considered: a circular model representing geometrically regular tumors and an elliptic model representing geometrically irregular tumors, both sharing the same area. The temperature distribution in the tumor and its surrounding healthy tissue was predicted by solving the Pennes’ bio-heat transfer equation (PBHTE). Both single- and multi-site injection strategies were explored. The results suggest that the multi-site injection strategies generally work well, while the single-site injection strategy fails even on the simplest circular tumor model. The more the injection sites, the better the performance. In particular, when the number of injection sites reaches eight, all temperature requirements can be nearly 100% satisfied in both tumor models. Whether or not including the minimum dose requirement in the objective function only affects the optimization results by less than 2%. The thermal dose was also assessed by considering both temperature and heat exposure time. It was found that the optimal multi-site injection strategies perform reasonably well for both tumor models. Although the setting is only two dimensional and the optimization is on very simplified tumor models, the framework adopted in this present study works well and can provide useful insights into magnetic hyperthermia treatment.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.ChemE/Transport Phenomen