A Direct Detection of Gas Accretion: The Lyman Limit System in 3C 232

The gas added and removed from galaxies over cosmic time greatly affects their stellar populations and star formation rates. QSO absorption studies in close QSO/galaxy pairs create a unique opportunity to study the physical conditions and kinematics of this gas. Here we present new Hubble Space Telescope (HST) images of the QSO/galaxy pair 3C 232/NGC 3067. The quasar spectrum contains a Lyman-limit absorption system (LLS) due to NGC 3067 at cz = 1421 km/s that is associated with the nearby SAB galaxy NGC 3067. Previous work identifies this absorber as a high-velocity cloud (HVC) in NGC 3067 but the kinematics of the absorbing gas, infalling or outflowing, were uncertain. The HST images presented here establish the orientation of NGC 3067 and so establish that the LLS/HVC is infalling. Using this system as a prototype, we extend these results to higher-z Mg II/LLS to suggest that Mg II/LLSs are a sight line sampling of the so-called "cold mode accretion" (CMA) infalling onto luminous galaxies. But to match the observed Mg II absorber statistics, the CMA must be more highly ionized at higher redshifts. The key observations needed to further the study of low-z LLSs is HST/UV spectroscopy, for which a new instrument, the Cosmic Origins Spectrograph, has just been installed greatly enhancing our observational capabilities.Comment: 9 pages, 5 figures, accepted by PAS

DOXORUBICIN-INDUCED, TNF-α-MEDIATED BRAIN OXIDATIVE STRESS, NEUROCHEMICAL ALTERATIONS, AND COGNITIVE DECLINE: INSIGHTS INTO MECHANISMS OF CHEMOTHERAPY INDUCED COGNITIVE IMPAIRMENT AND ITS PREVENTION

The works presented in this dissertation provide insights into the mechanisms of chemotherapy-induced cognitive impairment (CICI or “ChemoBrain”) and take steps toward outlining a preventive strategy. CICI is now widely recognized as a complication of cancer chemotherapy experienced by a large percentage of cancer survivors. Approximately fifty percent of existing FDA-approved anti-cancer drugs generate reactive oxygen species (ROS). Doxorubicin (Dox), a prototypical ROS-generating chemotherapeutic agent, produces the reactive superoxide radical anion (O2-•) in vivo. Dox treatment results in oxidation of plasma proteins, including ApoA-I, leading to TNF-α-mediated oxidative stress in plasma and brain. TNF-α elevation in brain leads to further central nervous system toxicity including mitochondrial dysfunction, neuronal death, and cognitive impairment. Co-administration of the antioxidant drug, 2-mercaptoethane sulfonate sodium (MESNA), prevents Dox-induced protein oxidation and subsequent TNF-α elevation in plasma without interfering with the cancer-killing ability of Dox. In studies presented in this dissertation, we measured oxidative stress in both brain and plasma of Dox-treated mice both with and without MESNA. MESNA ameliorated Dox-induced oxidative protein damage in plasma, confirming our prior studies, and in a new finding led to decreased oxidative stress in brain. Using novel object recognition (NOR), we demonstrated the Dox administration resulted in memory deficits. Using hydrogen magnetic resonance imaging spectroscopy (H1-MRS) techniques, we demonstrated that Dox administration led to a dramatic decrease in choline(phosphocholine)/creatine (Cho/Cr) ratios in mouse hippocampus. The activities of both phosphatidylcholine-specific phospholipase C (PC-PLC) and phospholipase D(PLD) were severely diminished following Dox administration. The activity of PC-PLC was preserved when MESNA was co-administered with Dox. In the absence of TNF-α, MRS-indexed Cho/Cr ratio, PLD activity, and mitochondrial oxygen consumption are preserved in brain, and markers of oxidative stress are reduced. Together with results from our previous studies, these results provide strong evidence that TNF-α is strongly associated, if not responsible for CICI. We also tested the notion that O2-• is responsible for Dox-induced plasma protein oxidation and TNF-α release. O2-• resulted in increased oxidative damage to proteins when added to plasma and increased levels of TNF-α in macrophage culture, providing strong evidence that O2-• is responsible for these Dox-induced toxicities

USING UNMANNED AERIAL SYSTEMS (UAS) AND PHOTOGRAMMETRY TO REMOTELY ASSESS LANDSLIDE EVENTS IN NEAR REAL-TIME

Commercially available unmanned aerial systems (UAS) and photogrammetry software have undergone rapid advancements in recent years. However, the use of UAS and photogrammetry techniques for monitoring surface landform deformation has not been adopted for the most part due to complicated workflows and complex UAS systems. This study demonstrates the ability to monitor landslides in near-real time with commercially available UAS and photogrammetry software using direct georeferencing and co- registration techniques. The results of this research were then assessed to develop an optimal workflow for the rapid assessment of surface deformations with direct georeferenced UAS obtained imagery and photogrammetry software

Letter from the Editor

The articles in this year\u27s edition of the General Assembly in Review focus on topics of legislative debate during the 2011 session of the Virginia General Assembly. We hope that this edition will give our readers insight into some of the important topics of the 2011 General Assembly and will facilitate further discussion of the important issues facing the Commonwealth

Letter from the Editor

The articles in this year\u27s edition of the General Assembly in Review focus on topics of legislative debate during the 2011 session of the Virginia General Assembly. We hope that this edition will give our readers insight into some of the important topics of the 2011 General Assembly and will facilitate further discussion of the important issues facing the Commonwealth

Optical Spectral Properties of Swift BAT Hard X-ray Selected Active Galactic Nuclei Sources

The Swift Burst Alert Telescope (BAT) survey of Active Galactic Nuclei (AGN) is providing an unprecedented view of local AGNs ( = 0.03) and their host galaxy properties. In this paper, we present an analysis of the optical spectra of a sample of 64 AGNs from the 9-month survey, detected solely based on their 14-195 keV flux. Our analysis includes both archived spectra from the Sloan Digital Sky Survey and our own observations from the 2.1-m Kitt Peak National Observatory telescope. Among our results, we include line ratio classifications utilizing standard emission line diagnostic plots, [O III] 5007 A luminosities, and H-beta derived black hole masses. As in our X-ray study, we find the type 2 sources to be less luminous (in [O III] 5007 A and 14-195 keV luminosities) with lower accretion rates than the type 1 sources. We find that the optically classified LINERs, H II/composite galaxies, and ambiguous sources have the lowest luminosities, while both broad line and narrow line Seyferts have similar luminosities. From a comparison of the hard X-ray (14-195 keV) and [O III] luminosities, we find that both the observed and extinction-corrected [O III] luminosities are weakly correlated with X-ray luminosity. In a study of the host galaxy properties from both continuum fits and measurements of the stellar absorption indices, we find that the hosts of the narrow line sources have properties consistent with late type galaxies.Comment: 84 pages, 20 figures, 17 tables, accepted in Ap