Jet-Topography Interactions Affect Energy Pathways to the Deep Southern Ocean

In the Southern Ocean, strong eastward ocean jets interact with large topographic features, generating eddies that feed back onto the mean flow. Deep-reaching eddies interact with topography, where turbulent dissipation and generation of internal lee waves play an important role in the ocean's energy budget. However, eddy effects in the deep ocean are difficult to observe and poorly characterized. This study investigates the energy contained in eddies at depth, when an ocean jet encounters topography. This study uses a two-layer ocean model in which an imposed unstable jet encounters a topographic obstacle (either a seamount or a meridional ridge) in a configuration relevant to an Antarctic Circumpolar Current frontal jet. The authors find that the presence of topography increases the eddy kinetic energy (EKE) at depth but that the dominant processes generating this deep EKE depend on the shape and height of the obstacle as well as on the baroclinicity of the jet before it encounters topography. In cases with high topography, horizontal shear instability is the dominant source of deep EKE, while a flat bottom or a strongly sheared inflow leads to deep EKE being generated primarily through baroclinic instability. These results suggest that the deep EKE is set by an interplay between the inflowing jet properties and topography and imply that the response of deep EKE to changes in the Southern Ocean circulation is likely to vary across locations depending on the topography characteristics

Observations of Submesoscale Variability and Frontal Subduction within the Mesoscale Eddy Field of the Tasman Sea

Submesoscale lenses of water with anomalous hydrographic properties have previously been observed in the East Australian Current (EAC) system, embedded within the thermocline of mesoscale anticyclonic eddies. The waters within these lenses have high oxygen content and temperature–salinity properties that signify a surface origin. However, it is not known how these lenses form. This study presents field observations that provide insight into a possible generation mechanism via subduction at upper-ocean fronts. High-resolution hydrographic and velocity measurements of submesoscale activity were taken across a front between a mesoscale eddy dipole downstream of the EAC separation point. The front had O(1) Rossby number, strong vertical shear, and flow conducive to symmetric instability. Frontogenesis was measured in conjunction with subduction of an anticyclonic water parcel, indicative of intrathermocline eddy formation. Twenty-five years of satellite imagery reveals the existence of strong mesoscale strain coupled with strong temperature fronts in this region and indicates the conditions that led to frontal subduction observed here are a persistent feature. These processes impact the vertical export of tracers from the surface and dissipation of mesoscale kinetic energy, implicating their importance for understanding regional ocean circulation and biological productivity

Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19

IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19. DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022). INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days. MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes. RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively). CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570

Wavy magnetohydrodynamic turbulence

Nonlinear closure models of the 2D magnetohydrodynamic equations predict that the turbulent diffusivity of magnetic fields in high magnetic Reynolds number flows will be strongly suppressed below the value predicted by simple kinematic models. The consequences of such r̀esistivity quenching' for models of dissipation and transport in magnetized flows are profound. However, to date, there has been little examination of the underlying assumptions implicitly made by such models --- (i) that the quenching is associated with a reduction in the cross- phase between the velocity and the magnetic potential, rather than a suppression of the turbulence itself, and (ii) that transport results from molecular collisions alone. In this dissertation, we revisit the 2D problem in an attempt to address these issues. To address (i), we examine the normalized cross-phase and its dependence on the initial magnetic field strength. We present the results of numerical simulations that are consistent with the current picture of resistivity quenching as primarily a suppression of transport of magnetic potential rather than turbulence intensity. To address (ii), the theory of turbulent resistivity in ẁavy' magnetohydrodynamic turbulence in 2D is presented. The goal is to explore the theory of resistivity quenching in a regime for which the mean-field theory can be rigorously constructed at large magnetic Reynolds number Rm. This is achieved by extending the simple 2D problem to include body forces, such as buoyancy or the Coriolis force, that convert large scale eddies into weakly interacting dispersive waves. Remarkably, adding an additional restoring force to the already tightly constrained system of high Rm magnetohydrodynamic turbulence in 2D can actually increase the turbulent resistivity, by admitting a spatial flux of magnetic potential, driven by wave interactions, that is not quenched at large \Rm. In the final chapter we address a closely related topic: the effect of magnetic linkage on the homogenization of vorticity in closed streamline flow. It is found that magnetic stresses acting on the bounding streamline can maintain a cross-stream gradient in the vorticity, thus disrupting the homogenization process and profoundly altering the nature of the turbulent enstrophy cascade in such flow

Turbulent diffusion of magnetic fields in two-dimensional magnetohydrodynamic turbulence with stable stratification.

We calculate the correction, due to nonlinear wave-wave interactions, to the Zel'dovich estimate for the turbulent diffusivity of magnetic fields in a model of two-dimensional magnetohydrodynamic turbulence in the presence of stable stratification. Such a model has some relevance to hydromagnetic turbulence in stellar interiors. The significance of this correction is that, unlike the lowest-order Zel'dovich balance, it is independent of the molecular resistivity eta and so will not vanish in the limit of a large magnetic Reynolds number, although the correction is O(sigma;{4}), where sigma is the wave slope, which necessarily is small. Thus, we are led to the counterintuitive result that the presence of stable stratification can actually increase the vertical flux of magnetic fields relative to that in 2D MHD turbulence without stratification