N-(Fluoren-9-ylmethoxy­carbon­yl)-l-aspartic acid 4-tert-butyl ester

The bond distances and bond angles of the title compound, C23H25NO6, are consistent with values typically found for fluoren-9-ylmethoxy­carbonyl-protected amino acids. The conformations of the backbone and the side chain are slightly different from those of l-aspartic acid. The crystal structure exhibits two inter­molecular hydrogen bonds, forming a two-dimensional sheet structure parallel to the ab plane

A novel approach to the synthesis of oligodeoxyribonucleotide boranophosphates

Deoxyribonucleoside 3′-boranophosphate derivatives including adenine, cytosine, guanine, and thymine bases were synthesized in good yields by the use of a new boranophosphorylation reaction. The reaction was found to be effective for the formation of internucleotidic boranophosphate linkages

N-(Fluoren-9-ylmethoxy­carbon­yl)-l-leucine

The title compound [systematic name: fluoren-9-yl N-(1-carb­oxy-3-methyl­butyl)carbamate], C21H23NO4, exhibits torsion angles that vary from the typical values found in other Fmoc-protected amino acids, viz. the orientations of the fluorene and carboxyl groups [C—O—C—C = 93.8 (2) and N—C—C=O = −23.6 (2)°]. The crystal structure exhibits two inter­molecular hydrogen bonds (O—H⋯O and N—H⋯O) that link the mol­ecules into two-dimensional sheets parallel to the ab plane

Experimental study of partial liquid ventilation in the setting of acute respiratory failure induced by sea water lung lavage in rabbits.

To study the effect of partial liquid ventilation (PLV) with perfluorocarbon on acute respiratory failure, 3 groups of 17 rabbits were examined to compare. After acute respiratory failure was induced by lung lavage with sea water in 12 of the 17 rabbits, 7 of the 12 rabbits were treated with conventional mechanical ventilation (AC group) and 5 of the 12 rabbits were treated with PLV using perfluorocarbon (AP group). The remaining 5 normal rabbits without acute respiratory failure were treated with PLV with perfluorocarbon as a control group (PL group). In the PL group, PaO2, PaCO2, blood pH, pulmonary compliance or pathological findings were not so changed after PLV. In the AC and AP groups, PaCO2 significantly increased, and in contrast, PaO2 and pulmonary compliance significantly decreased after lung lavage. However, these findings improved to almost the same levels as those of a control group within 2 h after the PLV treatment in the AP group, but in the AC group, these gradually deteriorated over time. As for the pathological findings, pulmonary vascular congestion, alveolar hemorrhage and inflammatory infiltration were observed in the AC group. However, these findings were not observed in the specimens of the AP group. From these results, PLV with perfluorocarbon was shown to be useful to improve gas exchange and pulmonary functions without major side effects.</p