Value of a new inflammatory parameter in malignant pleural mesothelioma prognosis

Malignant Pleural Mesothelioma (MPM) generallyassociated with asbestos exposure is a tumor withpoor prognosis. Modified Glasgow Prognostic Score(GPS) which may be a prognostic parameter in patientswith MPM is a designed based score including increasedC-reactive protein (CRP) levels and decreased albumin.In this study we aimed to investigate the effect of GPSscore on the prognosis of MPM and the role of other potentialfactors.Methods: In this retrospective planned study 140 histologicaldiagnosed MPM patients were included.Results: Mean age of 140 MPM patients were 52.92years (83 male and 57 female). A total of 91 patients hadenvironmental asbestos exposure and exposure timewas the 31 years. Symptoms of the patients started approximately4.8 months before the application. The mostfrequently seen symptoms were in 125 patients dyspnea,in 94 patients chest pain and in 22 patients weight loss.GPS score of the patients were as follows; 64 patientstwo, 14 patients one, 22 patients zero. Of the patients,112 died and 28 were alive. Mean survival time was 14months. Patients with GPS score 2 lived for 10 months,GPS score 1 lived for 15 and GPS score 0 lived for 18months. This difference was statistically significant. Furthermore,the male sex and age older than 65 years werefound as poor prognostic parameters on the survival.Conclusion: A simple and inexpensive parameter able tobe used to estimate the prognosis of MPM patients couldnot be developed .GPS score increases in inflammatoryconditions. GPS is a simple and inexpensive parameterthat can be used for detecting the severity of patients withMPM.Key words: Modified Glasgow Prognostic Score, MalignantPleural Mesothelioma, Prognosi

The importance of mean platelet volume in early mortality of pulmonary embolism

Objective: In this study whether mean platelet volume(MPV) is associated with early period hospital mortalityor not in patients with pulmonary embolism (PE) was investigated.Methods: Data of patients that hospitalized in chest diseasesclinic with the diagnosis of PE between the years2009-2012 were screened retrospectively from digital archivesystem. The demographic data, symptoms, treatmentoutcomes and MPV values in complete blood countof patients were recorded.Results: The mean age was 57.93 ± 18.52 years (16-91).The number of patients is 143 and 91 women (63.9%),52 men (36.4%), respectively. MPV values were availablefor 137 of 143 patients. 129 of patients were discharged,and 8 had died in the early period of hospitalization. Themean MPV value was 7.85 ± 1.40 fL in patients who experiencedand 9.08 ± 1.61 fL in died respectively. The differencewas statistically significant (p = 0.01).Conclusion: The results of this study suggests that increasedMPV value may be used as a marker for earlyhospital mortality in patients with PE. J Clin Exp Invest2013; 4 (3): 298-301Key words: Mean platelet volume, mortality, pulmonary embolis

Conventional method and ultrasound guided transbronchial needle aspiration techniques in the diagnosis of intrathoracic lymphadenopathies

Conventional transbronchial needle aspiration (TBNA) is one of the minimally invasive methods used for the diagnosis of intrathoracic lymphadenopathies, which is an effective, safe and cheap bronchoscopic technique. Endobronchial ultrasound (EBUS) guided TBNA is one of the most important advances in pneumology in recent years and has extended the diagnostic spectrum of bronchoscopic techniques. Today there are two different types of ultrasound probes for use with EBUS: radial and convex. The most important advantage of convex probe EBUS is that it allows real-time imaging while sample taken. To increase the diagnostic success, expansion of both conventional and ultrasound guided TBNA applications may reduce the need for invasive surgical procedures

Electrical Resistivity Tomography Survey to Assist The Landscape Project at the Macedonia Campus Area, Edirne, NW Turkey

An electrical. resistiviğı toünography (ERT) nıethod yielding an infornıation on resistivily changes in both vertical and lateral directions has been applied to contribute to landscape design by investigating groundwater potential in the Mqcedonia Campııs area (Edirne, north-westerıı Tıırkelı). The ERT studieş were performed using q Wenn.erSchlumberger electrode array along 24 profiles in ıhe directions of N-S and E-W. The ERT tomograms obtained by 2- D inversion of appareııt-ı"esistiııit! data clearly identiJied shallow sııbsurface conditions of the survey area. Based on the results, we can conclııde that groıındu,ater level has not been observed in the area since shallow subsıırf'ace is dominated by high clay conlent. Therefore, it is sııggested ıhaı ıuhen preparing the landscape design project for the area green infrastrııcture and xeriscaping will be used

Synthesis and Biological Evaluation of Novel Piperazine Containing Hydrazone Derivatives

Some hydrazone derivatives were synthesized and their potential anticholinesterase activities were examined. A series of eleven new compounds of N′-(2,4-disubstitutedbenzylidene)-2-(4-(4-nitrophenyl)piperazin-1-yl)acetohydrazide derivatives were obtained via reaction of 2-[4-(4-nitrophenyl)piperazin-1-yl]acetohydrazide with aromatic aldehydes. The chemical structures of the compounds were enlightened by FT-IR, 1H-NMR, 13C-NMR, and HRMS (ESI) spectral data. The inhibition potency of the compounds 3a–k against AChE and BuChE was measured and evaluated using a modification of Ellman’s spectrophotometric method. Among the tested compounds, compound 3c was assigned to be the most active derivative. Galantamine was used as a standard drug