GeneInfo_S2

Table with statistics and general information for each gene surveyed in the SCN

NovelExons_S4

Table with coordinates and additional information for identified novel exons expressed in the SCN

LincInfo_S3

Table with statistics and general information for each multi-exonic lincRNA expressed in the SCN

LincRNA_3187

A GTF file of the 3187 multi-exonic lincRNA expressed in the SCN

Primer_list_S1

Primer lis

Late gadolinium enhancement in 6 and 12 month mdx mice.

<p><i>Upper left;</i> late gadolinium enhancement in 3 of 9 mdx mice at 6 months (arrows). <i>Lower panel;</i> late gadolinium enhancement was present in the septum of all mdx mice imaged at 12 months in both long axis <i>(left)</i> and short axis <i>(right)</i> views as well as RV wall (arrows). <i>Upper right;</i> no late gadolinium enhancement was present in wild type mice (WT) at any time point. <i>Far right;</i> Sirius red staining of cryosections confirmed presence of fibrosis in the septum and RV wall of mdx mouse hearts.</p

Cardiac MRI.

<p><i>In vivo</i> short axis cine-MR images of the same wild type and mdx mouse imaged at 1, 3, 6, 9 and 12 months.</p

Left and right ventricular cardiac morphology and function.

<p>Results are presented as means ± SEM.</p

Left and right ventricular cardiac function under dobutamine stress.

<p>Results are presented as means ± SEM.</p><p><i>(note: dobutamine stress increased mortality in older mdx mice)</i>.</p

Greater cardiac remodeling in hearts with more late gadolinium enhancement.

<p>End diastolic volumes <i>(left)</i> and end systolic volumes <i>(middle)</i> and left ventricular mass <i>(right)</i> were increased in hearts with more segments showing late gadolinium enhancement.</p