Multiwavelength and Multi-CO View of the Minor Merger Driven Star Formation in the Nearby LIRG NGC 3110

Y.K., T.S., and the other authors thank the ALMA staff for their kind support. This work was supported by the ALMA Japan Research Grant of NAOJ Chile Observatory, NAOJALMA-0114. D.E. acknowledges support from a Beatriz Galindo senior fellowship (BG20/00224) from the Spanish Ministry of Science and Innovation. This paper makes use of the following ALMA data: ADS/JAO.ALMA#2013.0.01172. S. ALMA is a partnership of ESO (representing its member states), NSF (USA) and NINS (Japan), together with NRC (Canada), MOST and ASIAA (Taiwan), and KASI (Republic of Korea), in cooperation with the Republic of Chile. The Joint ALMA Observatory is operated by ESO, AUI/NRAO, and NAOJ. This NVAS image was produced as part of the NRAO VLA Archive Survey, (c) AUI/NRAO. This research has made use of the NASA/IPAC Extragalactic Database (NED), which is funded by the National Aeronautics and Space Administration and operated by the California Institute of Technology. This work is based in part on observations made with the Spitzer Space Telescope, which is operated by the Jet Propulsion Laboratory, California Institute of Technology under a contract with NASA.We present Atacama Large Millimeter/submillimeter Array observations of multiple (CO)-C-12, (CO)-C-13, and (CO)-O-18 lines and 2.9 mm and 1.3 mm continuum emission toward the nearby interacting luminous infrared galaxy NGC 3110, supplemented with similar spatial resolution H alpha, 1.4 GHz continuum, and K-band data. We estimate the typical CO-to-H-2 conversion factor of 1.7 M (circle dot) (K km s(-1) pc(2))(-1) within the disk using local thermal equilibrium-based and dust-based H-2 column densities, and measure the 1 kpc scale surface densities of the star formation rate (sigma(SFR)), super star clusters (sigma(SSC)), molecular gas mass, and star formation efficiency (SFE) toward the entire gas disk. These parameters show a peak in the southern part of the southern spiral arm (SFE similar to 10(-8.2) yr(-1), sigma(SFR) similar to 10(-0.6) M (circle dot) kpc(-2) yr(-1), sigma(SSC) similar to 6.0 kpc(-2)), which is likely attributable to the ongoing tidal interaction with the companion galaxy MCG-01-26-013, as well as toward the circumnuclear region. We also find that thermal free-free emission contributes to a significant fraction of the millimeter continuum emission at the position of the southern peak. These measurements imply that the peak of the southern arm is an active and young star-forming region, whereas the central part of NGC 3110 is a site of long-continued star formation. We suggest that during the early stage of the galaxy-galaxy interaction in which the mass ratio was high in NGC 3110, fragmentation along the main galaxy arms is an important driver of merger-induced star formation, and that massive gas inflow results in dusty nuclear starbursts.ALMA Japan Research Grant of NAOJ Chile Observatory NAOJALMA-0114Spanish Government BG20/00224National Aeronautics & Space Administration (NASA

Molecular Gas and Star Formation Properties in Early Stage Mergers:SMA CO(2-1) Observations of the LIRGs NGC 3110 and NGC 232

Mergers of galaxies are an important mode for galaxy evolution because they serve as an efficient trigger of powerful starbursts. However, observational studies of the molecular gas properties during their early stages are scarce. We present interferometric CO(2-1) maps of two luminous infrared galaxies (LIRGs), NGC 3110 and NGC 232, obtained with the Submillimeter Array (SMA) with ~ 1 kpc resolution. While NGC 3110 is a spiral galaxy interacting with a minor (14:1 stellar mass) companion, NGC 232 is interacting with a similarly sized object. We find that such interactions have likely induced in these galaxies enhancements in the molecular gas content and central concentrations, partly at the expense of atomic gas. The obtained molecular gas surface densities in their circumnuclear regions are $\Sigma_{\rm mol}~\gtrsim10^{2.5}$ M$_\odot$ pc$^{-2}$, higher than in non-interacting objects by an order of magnitude. Gas depletion times of ~ 0.5 - 1 Gyr are found for the different regions, lying in between non-interacting disk galaxies and the starburst sequence. In the case of NGC 3110, the spiral arms show on average 0.5 dex shorter depletion times than in the circumnuclear regions if we assume a similar H$_2$-CO conversion factor. We show that even in the early stages of the interaction with a minor companion, a starburst is formed along the circumnuclear region and spiral arms, where a large population of SSCs is found (~350), and at the same time a large central gas concentration is building up which might be the fuel for an active galactic nucleus. The main morphological properties of the NGC 3110 system are reproduced by our numerical simulations and allow us to estimate that the current epoch of the interaction is at ~ 150 Myrs after closest approach.Comment: 30 pages. Accepted for publication in Ap

Poor prognostic factors of Sézary syndrome: A retrospective single‐center study from Japan

Abstract Objectives Although the prognosis of Sézary syndrome (SS) is highly unfavorable, the prognostic factors have not been fully understood. In this study, we tried to investigate the prognostic factors in Japanese SS patients for the first time. Methods We performed a retrospective cohort study of 19 SS patients who visited our hospital between January 1, 1999, and December 31, 2019. The collected clinical findings were age, gender, performance status (PS), and TNMB staging at diagnosis. TNMB staging was determined according to the International Society for Cutaneous Lymphomas and the cutaneous task force of the European Organization of Research and Treatment of Cancer criteria. The collected hematological findings were serum levels of soluble IL‐2 receptor (sIL‐2R), lactate dehydrogenase (LDH), thymus and activation‐regulated chemokine (TARC), and immunoglobulin E (IgE), Sézary cell count, Sézary cell ratio among white blood cells, and eosinophil count in peripheral blood at diagnosis. Results We analyzed the correlations between overall survival and various clinical and hematological findings. In the log‐rank test, PS1‐3, N2‐3 stage, higher serum levels of LDH (≥355 IU/L), sIL‐2R (≥1729 U/ml) and TARC (≥19,867 pg/ml), and higher Sézary cell count (≥7480/μl) and Sézary cell ratio among white blood cells (≥52%) at diagnosis were associated with decreased overall survival. Conclusions This is the first report evaluating prognostic factors in Asian SS patients. This study may contribute to selecting the treatment strategy and improving survival and quality of life of Asian SS patients

IgG4‐related retroperitoneal fibrosis induced by nivolumab and ipilimumab in a patient with non‐small cell lung cancer: A case report

Abstract IgG4‐related diseases are adverse events that occur after receiving treatment with immune checkpoint inhibitors (ICI). This study reports the first case of IgG4‐related retroperitoneal fibrosis after the administration of chemotherapy with nivolumab and ipilimumab (NI therapy). An 80‐year‐old man developed lower abdominal pain eight months after NI therapy was initiated. Although the primary lesion maintained its reduced size on computed tomography, there was an increase in the soft tissue shadows intensity around the abdominal aorta, bladder, and seminal vesicles, suggesting retroperitoneal fibrosis. Blood tests showed elevated IgG4 levels. Computed tomography‐guided biopsy of the retroperitoneum showed B cell‐dominant lymphocyte infiltration consistent with IgG4‐related retroperitoneal fibrosis and characteristic CD8‐positive lymphocyte infiltration, suggestive of the involvement of cytotoxic T cells. Based on the clinical, imaging, and pathological findings, the patient was diagnosed with IgG4‐related retroperitoneal fibrosis due to ICI. Immunotherapy discontinuation alone did not result in improvement; therefore, steroid therapy was initiated. In clinical practice, IgG4‐related retroperitoneal fibrosis can occur as an immune‐related adverse event when administering anti‐PD‐1 and anti‐CTLA‐4 antibodies for cancer immunotherapy. Early steroid therapy could be effective in controlling this immune‐related adverse event