Construction of next generation mobile video on demand delivery system using broadcast and communication integration environments

GCCE2015 : IEEE 4th Global Conference on Consumer Electronics , Oct 27-30, 2015 , Osaka, JapanWatching high quality videos anytime, anywhere is expected because mobile devices become popular. However, if mobile devices try to watch a video at the same time via a wireless network, the concentrated loads to delivery server cause a delay and a stop of playing videos on client devices. Therefore, in this paper, we realize a mobile video on demand delivery system that mobile devices can watch high quality videos continuously by integrated methods of broadcast and communication. We delvelop the prototype system and have practical experiments to evaluate the proposed system

A P2P Sensor Data Stream Delivery System to Accommodate Heterogeneous Cycles Using Skip Graphs

3PGCIC2015 : 10th International Conference on P2P, Parallel, Grid, Cloud and Internet Computing , Nov 4-6, 2015 , Krakow, PolandIn this paper, we propose a method using skip graphs to delivery sensor data streams with heterogeneous delivery cycles. Currently skip graphs have been proposed as one of structured overlay networks that construct links among nodes based on a specific rule. The proposed method sorts nodes by their delivery cycles and constructs delivery paths based on skip graphs. We confirmed in simulation that our proposed method can delivery sensor data with heterogeneous cycles using skip graphs to distribute the load of source node

A Node Replication Method to Guarantee Reachability for P2P Sensor Data Stream Delivery System on Heterogeneous Churn Situations

COMPSAC2015 : The 39th Annual International Computers, Software & Applications Conference , Jul 1-5, 2015 , Taichung, TaiwanIn this paper, we propose a method to construct scalable sensor data stream delivery system that guarantees the specified QoS of the delivery, i.e. Total reachbility to destinations even in a heterogeneous churn situation of the delivery server resources (nodes). There were some P2P-based methods to construct scalable and efficient sensor data stream system that accommodates different delivery cycles by distributing communication loads of the nodes. However, existing methods could not guarantee the QoS of the delivery when the nodes on the system has heterogeneous churn rate. Our method extends existing method, which assigns the relay nodes based on the distributed hashing of the time-to-deliver, to decide the number of replication nodes according to the churn rate of each node and delivery paths. By simulations, we confirmed that our proposed method can guarantee the required reach ability avoiding to increase unnecessary resource assignment costs

Two XMAP215/TOG Microtubule Polymerases, Alp14 and Dis1, Play Non-Exchangeable, Distinct Roles in Microtubule Organisation in Fission Yeast

Proper bipolar spindle assembly underlies accurate chromosome segregation. A cohort of microtubule-associated proteins orchestrates spindle microtubule formation in a spatiotemporally coordinated manner. Among them, the conserved XMAP215/TOG family of microtubule polymerase plays a central role in spindle assembly. In fission yeast, two XMAP215/TOGmembers, Alp14 and Dis1, share essential roles in cell viability; however how these two proteins functionally collaborate remains undetermined. Here we show the functional interplay and specification of Alp14 and Dis1. Creation of new mutant alleles of alp14, which display temperature sensitivity in the absence of Dis1, enabled us to conduct detailed analyses of a double mutant. We have found that simultaneous inactivation of Alp14 and Dis1 results in early mitotic arrest with very short, fragile spindles. Intriguingly, these cells often undergo spindle collapse, leading to a lethal “cut” phenotype. By implementing an artificial targeting system, we have shown that Alp14 and Dis1 are not functionally exchangeable and as such are not merely redundant paralogues. Interestingly, while Alp14 promotes microtubule nucleation, Dis1 does not. Our results uncover that the intrinsic specification, not the spatial regulation, between Alp14 and Dis1 underlies the collaborative actions of these two XMAP215/TOG members in mitotic progression, spindle integrity and genome stability.This work was supported by the Japan Society for the Promotion of Science (JSPS) (KAKENHI Scientific Research (A) 16H02503 and the Program for Advancing Strategic International Networks to Accelerate the Circulation of Talented Researchers (S2902) to T.T. and Scientific Research (C) 19K05813 to M.Y.)

Proposal of a Logical Sensor Architecture using WoT-Based Edge Microservices

K. Miyagoshi, Y. Teranishi, T. Kawakami, T. Yoshihisa and S. Shimojo, "Proposal of a Logical Sensor Architecture using WoT-Based Edge Microservices," 2020 IEEE 44th Annual Computers, Software, and Applications Conference (COMPSAC), Madrid, Spain, 2020, pp. 1223-1228, doi: 10.1109/COMPSAC48688.2020.00-89.2020 IEEE 44th Annual Computers, Software, and Applications Conference (COMPSAC) [13-17 July 2020, Madrid, Spain

A microtubule polymerase cooperates with the kinesin-6 motor and a microtubule cross-linker to promote bipolar spindle assembly in the absence of kinesin-5 and kinesin-14 in fission yeast

Accurate chromosome segregation relies on the bipolar mitotic spindle. In many eukaryotes, spindle formation is driven by the plus-end–directed motor kinesin-5 that generates outward force to establish spindle bipolarity. Its inhibition leads to the emergence of monopolar spindles with mitotic arrest. Intriguingly, simultaneous inactivation of the minus-end–directed motor kinesin-14 restores spindle bipolarity in many systems. Here we show that in fission yeast, three independent pathways contribute to spindle bipolarity in the absence of kinesin-5/Cut7 and kinesin-14/Pkl1. One is kinesin-6/Klp9 that engages with spindle elongation once short bipolar spindles assemble. Klp9 also ensures the medial positioning of anaphase spindles to prevent unequal chromosome segregation. Another is the Alp7/TACC-Alp14/TOG microtubule polymerase complex. Temperature-sensitive alp7cut7pkl1 mutants are arrested with either monopolar or very short spindles. Forced targeting of Alp14 to the spindle pole body is sufficient to render alp7cut7pkl1 triply deleted cells viable and promote spindle assembly, indicating that Alp14-mediated microtubule polymerization from the nuclear face of the spindle pole body could generate outward force in place of Cut7 during early mitosis. The third pathway involves the Ase1/PRC1 microtubule cross-linker that stabilizes antiparallel microtubules. Our study, therefore, unveils multifaceted interplay among kinesin-dependent and -independent pathways leading to mitotic bipolar spindle assembly.This work was supported by the Japan Society for the Promotion of Science (JSPS) (KAKENHI Scientific Research [A] 16H02503 to T.T., a Challenging Exploratory Research grant 16K14672 to T.T., Scientific Research [C] 16K07694 to M.Y.), the Naito Foundation (T.T.), and the Uehara Memorial Foundation (T.T.)

A Lightweight Multi-receiver Encryption Scheme with Mutual Authentication

"In this paper, we propose a lightweight multi-receiver encryption scheme for the device to device communications on Internet of Things (IoT) applications. In order for the individual user to control the disclosure range of his/her own data directly and to prevent sensitive personal data disclosure to the trusted third party, the proposed scheme uses device-generated public keys. For mutual authentication, third party generates Schnorr-like lightweight identity-based partial private keys for users. The proposed scheme provides source authentication, message integrity, replay-attack prevention and implicit user authentication. In addition to more security properties, computation expensive pairing operations are eliminated to achieve less time usage for both sender and receiver, which is favourable property for IoT applications. In this paper, we showed a proof of security of our scheme, computational cost comparison and experimental performance evaluations. We implemented our proposed scheme on real embedded Android devices and confirmed that it achieves less time cost for both encryption and decryption comparing with the existing most efficient certificate-based multi-receiver encryption scheme and certificateless multi-receiver encryption scheme.

Self-pulsation and excitability of blue-violet InGaN lasers

This article gives a review of our latest results on the self-pulsation and excitability properties of blue-violet lasers. A number of investigations of the phenomena in InGaN lasers with different designs are described. The bifurcations, which are the origin of the phenomena, are identified and the effects of the lasers parameters on device dynamics are discussed. It is shown how different laser structures can be used to control device behaviour and the dependence of self-pulsation and excitability behaviour on laser geometry is discussed. Finally, agreement between the results of numerical calculations and experimental measurements on self-pulsation is demonstrated

Induction of cyclooxygenase-2 in human synovial cells by β2-microglobulin

Induction of cyclooxygenase-2 in human synovial cells by β2-microglobulin.BackgroundProstaglandins (PGs) are important mediators of inflammation in arthritis. We evaluated the role of the cyclooxygenase-2 (COX-2) enzyme, which regulates PG biosynthesis, in osteoarthropathy associated with hemodialysis-associated amyloidosis (HAA) by characterizing COX-2 expression in β2-microglobulin–treated human synovial cells.MethodsWe examined the effects of β2-microglobulin (β2m), a major constituent protein of amyloid fibrils in HAA, on the COX-2 protein and mRNA expression in human synovial cells using Western blot and reverse transcriptase-polymerase chain reaction.Resultsβ2m selectively increased the biosynthesis of COX-2 protein and induction of COX-2 mRNA in a dose-dependent manner. Immunoabsorption of β2m–containing media by anti-β2m–specific antibody abrogated β2m–mediated COX-2 expression on synovial cells. On the other hand, dexamethasone markedly suppressed the induction of COX-2 protein and mRNA in β2m–stimulated synovial cells.ConclusionsOur results suggest that induction of COX-2 expression by β2m may be an important component of the inflammatory process in hemodialysis-associated osteoarthropathy

Unmanipulated HLA 2–3 Antigen-Mismatched (Haploidentical) Stem Cell Transplantation Using Nonmyeloablative Conditioning

AbstractThe major problems in human leukocyte antigen (HLA)-mismatched stem cell transplantation (SCT) are graft failure and graft-versus-host disease (GVHD). Less-intensive regimens should be associated with a lower release of inflammatory cytokines and possibly less GVHD. The objective of this study was to investigate whether HLA-haploidentical SCT can be performed using nonmyeloablative conditioning and pharmacologic GVHD prophylaxis, including glucocorticoids. Using conditioning consisting of fludarabine, busulfan, and anti–T-lymphocyte globulin and GVHD prophylaxis consisting of tacrolimus and methylprednisolone (1 mg/kg/day), 26 patients who had hematologic malignancies in an advanced stage or with a poor prognosis underwent transplantation using peripheral blood stem cells from an HLA-haploidentical donor (2–3 antigen mismatches in the graft-versus-host [GVH] direction) without T-cell depletion. All patients except for 1 achieved donor-type engraftment. Rapid hematologic engraftment was achieved (neutrophils > 0.5 × 109/L on day 12 and platelets > 20 × 109/L on day 12), with full donor chimerism achieved by day 14. Fifteen patients did not develop acute GVHD clinically, and only 5 patients developed grade II GVHD. The recovery of CD4+ T cells was delayed compared with that of CD8+ T cells. Sixteen of the 26 patients are alive in complete remission. Four died of transplantation-related causes, and 6 died of progressive disease. These data suggest that nonmyeloablative conditioning, GVHD prophylaxis consisting of tacrolimus and methylprednisolone, and early therapeutic intervention for the GVH reaction allow stable engraftment and effectively suppress GVHD in HLA 2–3 antigen-mismatched SCT