On the Iteration Method for the Optimal Transmission System Planning

The optimal transmission system design problem can be formulated by an integer linear program when the construction cost characteristics are expressed by a staircase function. In this paper, we deal with the iteration method to obtain more accurate approximate solution of integer linear program and the procedure to solve effectively the large linear program by use of a decomposition principle and a network flow theory. Two examples on this problem are presented

Some Implications of Perturbative Approach to AdS/CFT Correspondence

We show some implications of the approach to AdS/CFT correspondence based on Type IIB string in the flat space-time with D3-branes proposed in our previous paper. We discuss a correspondence for high energy scattering amplitudes of N=4 super-Yang-Mills proposed recently. We also discuss AdS/CFT correspondence at finite temperature. Our approach provides clear understanding of these issues.Comment: 14 pages, 5 figures, references added, discussions on IR regularization clarifie

Long-term maintenance of hemoglobin levels in hemodialysis patients treated with bi-weekly epoetin beta pegol switched from darbepoetin alfa: a single-center, 12-month observational study in Japan

Recent evidence on maintenance administration of epoetin beta pegol, a continuous erythropoiesis receptor activator (CERA), in dialysis patients shows the clinical benefit of bi-weekly administration (Q2W) in improving hematopoiesis and iron use efficiency. We undertook a single-center observational study of 33 Japanese maintenance dialysis patients, whose anemia had been kept stable through weekly administration (Q1W) of darbepoetin (DA), to evaluate the effectiveness of CERA Q2W switched from DA in maintaining hemoglobin (Hb) levels over a 12-month period. The target Hb level was 10.0–12.0 g/dL. Throughout the 12-month period, the mean Hb was stably maintained at 10.5–10.8 g/dL, 69.7–87.9% of the patients achieving the target Hb level. The mean CERA dose was within the range of 62.9–78.8 µg/2 weeks. The average CERA dose adjustment frequency after switching was low at 0.42–0.67 times/3 months. In both subgroups stratified by the DA dose prior to the switch, Hb levels were kept stable during CERA administration; however, in the low-dose group (10–20 µg/week of DA), the CERA and iron doses decreased over time, whereas in the high-dose group (30–60 µg/week of DA) they remained unchanged. CERA Q2W achieved long-term successful anemia management in Japanese maintenance dialysis patients after switching from DA Q1W. CERA dose was adjusted based on an overall consideration of past changes in Hb levels, erythropoiesis-stimulating agent and iron doses. Subgroup analysis showed the CERA dose in the low-dose group decreased continuously, due possibly to a long-term improvement in iron use efficiency

Remarkable Regression of an Osteolytic Lesion of Large Cell Lung Cancer Treated with Zoledronic Acid: A Case Report

Zoledronic acid suppresses osteoclastic changes and reduces the risk of cancer-induced skeletal-related events. Moreover, it has been reported to have antitumor effects. The authors here present a case of a male patient with large cell lung cancer who had an osteolytic lesion in the thoracic vertebrae. The cancer was moderately sensitive to radiation therapy but barely sensitive to chemotherapy with cytotoxic agents. However, it was markedly regressed after zoledronic acid monotherapy, and the patient's symptoms almost disappeared. This remarkable response of large cell lung cancer to zoledronic acid monotherapy is rare

AdS/CFT Correspondence as a Consequence of Scale Invariance

We study an anisotropic scale transformation in the worldsheet description of D3-branes in Type IIB theory, and show that the transformation is really a symmetry in a region near D3-branes. AdS/CFT correspondence follows from this symmetry. We will explicitly show that Wilson loops in N=4 supersymmetric Yang-Mills theory and minimal surfaces in AdS_5 are related by the symmetry. The functional form of a supersymmetric Wilson loop operator is naturally derived from our worldsheet point of view.Comment: 20 pages, 8 figures, references adde