VPL appoints new director

Vancouver Public Library is pleased to announce that Christina de Castell has been appointed Director, Resources & Technology. A BCLA President's Award recipient, Christina is an active BCLA member and former Treasurer

From Mill Town to Mill Town: The Transition of a New England Town from a Textile to a High-Technology Economy

This article describes and analyzes the economic transformation of Maynard, Massachusetts. Located twenty-six miles west of Boston, Maynard was the home of the world\u27s largest woolen mill. In 1950 the mill closed and 1,200 jobs were lost. During the next ten years, the town gradually recovered as the mill became the home of several innovative companies. Ultimately, the mill became the headquarters for the world\u27s largest manufacturer of minicomputers. The circle is now complete: the mill is full and houses a company that claims a world\u27s largest designation. The article analyses the rise and fall of the American Woolen Company; examines the steps taken to stimulate recovery, and their results; identifies and examines the important elements that led to the economic transformation; and offers potential lessons for planners in towns undergoing similar changes

TANGO: Transparent heterogeneous hardware Architecture deployment for eNergy Gain in Operation

The paper is concerned with the issue of how software systems actually use Heterogeneous Parallel Architectures (HPAs), with the goal of optimizing power consumption on these resources. It argues the need for novel methods and tools to support software developers aiming to optimise power consumption resulting from designing, developing, deploying and running software on HPAs, while maintaining other quality aspects of software to adequate and agreed levels. To do so, a reference architecture to support energy efficiency at application construction, deployment, and operation is discussed, as well as its implementation and evaluation plans.Comment: Part of the Program Transformation for Programmability in Heterogeneous Architectures (PROHA) workshop, Barcelona, Spain, 12th March 2016, 7 pages, LaTeX, 3 PNG figure

Building a national Infection Intelligence Platform to improve antimicrobial stewardship and drive better patient outcomes:the Scottish experience

Background: The better use of new and emerging data streams to understand the epidemiology of infectious disease and to inform and evaluate antimicrobial stewardship improvement programmes is paramount in the global fight against antimicrobial resistance. Objectives: To create a national informatics platform that synergises the wealth of disjointed, infection-related health data, building intelligence capability that allows rapid enquiry, generation of new knowledge and feedback to clinicians and policy makers. Methods: A multi-stakeholder community, led by the Scottish Antimicrobial Prescribing Group, secured government funding to deliver a national program of work centred on three key aspects: technical platform development with record linkage capability across multiple datasets; a proportionate governance approach to enhance responsiveness; generation of new evidence to guide clinical practice. Results: The National Health Service Scotland Infection Intelligence Platform (IIP) is now hosted within the national health data repository to assure resilience and sustainability. New technical solutions include simplified “data views” of complex, linked datasets and embedded statistical programmes to enhance capability. These developments have enabled responsiveness, flexibility and robustness in conducting population-based studies including a focus on intended and unintended effects of antimicrobial stewardship interventions and quantification of infection risk factors and clinical outcomes. Conclusion: We have completed the build and test phase of IIP, overcoming the technical and governance challenges and produced new capability in infection informatics, generating new evidence for improved clinical practice. This provides a foundation for expansion and opportunity for global collaborations

Prophylactic plasma exchange in CD46-associated atypical haemolytic uremic syndrome

Patients with atypical haemolytic uremic syndrome (aHUS) with a mutation in the gene encoding membrane cofactor protein (CD46) are known to have a better prognosis than those with mutations in factor H (CFH) or factor I (CFI), but a small number of the former still proceed to end-stage renal failure. Plasma therapy (PE) is the recommended approach to treat both acute episodes and prevent recurrences in aHUS, but studies have yet to show PE efficacy in aHUS associated with a CD46 mutation. The factors determining failure to treatment are not clear and may be related to the mutation involved or to insufficient treatment. Our experience of PE in a family of three sisters with CFH-associated aHUS suggests that intensive and prophylactic PE allows renal function to be maintained in both native kidneys and allografts. The success of this strategy has led us to use it in all cases of aHUS. Here, we describe the effect of this strategy in a child with aHUS and a CD46 mutation. The initial episode was treated with daily PE, resulting in the recovery of renal function. However, over the next 4 years, there was a progressive decline in renal function to end-stage renal failure, with evidence of an on-going thrombotic microangiopathy despite continuous prophylactic PE. Prophylactic PE does not influence the natural course of aHUS and CD46 mutation

Energy efficiency embedded service lifecycle: Towards an energy efficient cloud computing architecture

The paper argues the need to provide novel methods and tools to support software developers aiming to optimise energy efficiency and minimise the carbon footprint resulting from designing, developing, deploying and running software in Clouds, while maintaining other quality aspects of software to adequate and agreed levels. A cloud architecture to support energy efficiency at service construction, deployment, and operation is discussed, as well as its implementation and evaluation plans.Postprint (published version

Plasma therapy in atypical haemolytic uremic syndrome: lessons from a family with a factor H mutation

Whilst randomised control trials are undoubtedly the best way to demonstrate whether plasma exchange or infusion alone is the best first-line treatment for patients with atypical haemolytic uremic syndrome (aHUS), individual case reports can provide valuable information. To that effect, we have had the unique opportunity to follow over a 10-year period three sisters with aHUS associated with a factor H mutation (CFH). Two of the sisters are monozygotic twins. A similar natural evolution and response to treatment would be expected for the three patients, as they all presented with the same at-risk polymorphisms for CFH and CD46 and no identifiable mutation in either CD46 or CFI. Our report of different modalities of treatment of the initial episode and of three transplantations and relapses in the transplant in two of them, strongly suggest that intensive plasma exchange, both acutely and prophylactically, can maintain the long-term function of both native kidneys and allografts. In our experience, the success of plasma therapy is dependent on the use of plasma exchange as opposed to plasma infusion alone, the prolongation of daily plasma exchange after normalisation of haematological parameters followed by prophylactic plasma exchange, the use of prophylactic plasma exchange prior to transplantation and the use of prophylactic plasma exchange at least once a week posttransplant with immediate intensification of treatment if there are any signs of recurrence

Intimate partner violence, interpersonal aggression, and life history strategy

We integrate life history (LH) theory with "hot/cool" systems theory of self-regulation to predict sexually and socially coercive behaviors, including intimate partner violence (IPV) and interpersonal aggression (IPA). LH theory predicts that a variety of traits form LH strategies: adaptively coordinated behavioral clusters arrayed on a continuum from slow to fast. We test structural models examining 2 propositions: (a) "hot" cognitive processes, promoted by faster LH strategies, increase the likelihood of sexually/socially coercive behaviors that make up IPV and IPA; (b) "cool" cognitive processes, promoted by slower LH strategies, buffer against the likelihood of sexually/socially coercive behaviors that make up IPV and IPA. We present single and multisample structural equations models (SEMs and MSEMs) testing hypothesized causal relations among these theoretically specified predictors with IPV and IPA. Study 1 develops a Structural Equation Model for IPV; Study 2 extends the model to IPA using MSEM and provides 5 cross-cultural constructive replications of the findings. Integrating LH theory and hot/cool systems analysis of cognitive processes is a promising and productive heuristic for future research on IPV and IPA perpetration and victimization. </p