A case report of brain abscess caused by carbapenem- resistant Klebsiella pneumoniae

The treatment of infections caused by carbapenem-resistant Klebsiella pneumoniae (CR-Kp) strains is difficult due to the limited antimicrobial options and high mortality. There are many reports on intracranial infections caused by CR-Kp, but only a few on brain abscesses caused by CR-Kp. Here, we present a case of brain abscess caused by CR-Kp successfully treated with combined antibiotics. A 26-year-old male patient was admitted to our hospital due to high fever and headache. His past medical history includes a surgical intervention due to an acute subdural hematoma, performed at an external healthcare center. After the current diagnosis of cerebral abscess, he underwent two surgeries. During the procedure, multiple cerebral abscesses were drained and capsulotomies were performed under ultrasound guidance. The combination of meropenem and vancomycin was started. The contents of the abscesses were sent to the microbiology and pathology laboratory. On the 3rd day of treatment, the medical team was informed that CR-Kp grew in an abscess culture. The patient's treatment was changed to meropenem + colistin + tigecycline. The patient developed electrolyte disturbances during the follow-up and this was considered an adverse effect of colistin. On the 41st day of treatment, colistin was discontinued, fosfomycin was added, and meropenem and tigecycline were maintained. Treatment was discontinued on the 68th day, when the patient was discharged. The general condition of the patient, who has been followed up for two years, is satisfactory. The treatment of CR-Kp infections should be individualized, and the pharmacokinetics and pharmacodynamics of antibiotics should be considered in each case

GPU tabanlı kızılötesi iz modelleme ve sahne benzetimi.

The need of a fast and high fidelity scene simulation system is important for the development of modern infrared (IR) imaging systems. The performance testing of these systems is expensive and also depends on environment conditions. However, computer based systems can provide a cost effective alternative to field trials. Ray tracing provides physical accuracy and photo realism for scene generation. However, it has computationally intensive nature and conventionally used for non-real time applications. The development of Graphics Processor Unit (GPU) technology makes ray tracing more available for real time applications. NVIDIA OptiX ray tracing engine, runs on top of the NVIDIA CUDA parallel computing architecture, is primarily applied on visual band rendering and it has not been yet used in physics based scene simulation in the IR region. In this thesis work, an effort is made to model physics based IR scene simulation with OptiX. The developed system is tested on several benchmarks and also the effects of the signature components are analyzed. The results show that spectral dependency of the radiometric data and atmosphere effects are important and must be taken into account. Moreover, the results show that current GPU technology can generate high fidelity IR images at high frame rates.M.S. - Master of Scienc