A Hybrid Approach for Recommendation System based on Web Mining

The significant issue of many on-line sites is the introduction of numerous decisions to the customer at once; this for the most part brings about strenuous and tedious in finding the correct item or data on the site. In the traditional methodologies, KNN based classification strategies were utilized which depended on suggestion handle. These have some real issue if the information differs. The arrangement approaches that were utilized as a part of customary work are fit just if the data variation is inside the cluster that they have. However, in the event that the data goes out of bound it is hard to perform classification. In this way, there is a need to include a classifier approach that can work in such conditions. For this, a hybrid approach comprising of Multi-Layer ANN and k-NN is proposed in order to take proper choices if there should be an occurrence of data variation. The proposed idea introduces an intelligent approach which captures the clients going out of bound and adds them into the cluster, so that they can be recommended to the user and no client is skipped

Single-molecule protein dynamics during DNA replication

Observing the processes of life that occur in all cellular organisms at the level of single molecules has allowed a deeper understanding of the dynamic processes taking place in complex biological systems. There has been a strong growth in the application of molecular biophysics to visualize in real time the behaviour of single molecules within a reaction, transforming our perception of the molecular processes that occur within a cell. A multitude of proteins participates across the genome to support the processes of replication, transcription, translation, repair and recombination. The continuous interplay of these proteins on the DNA produces unavoidable physical conflicts that have their own impact on genomic stability. Beyond the complexities of the cellular processes that involve DNA as a reaction partner, the duplex is also constantly exposed to DNA-damaging agents as a result of environmental factors such as UV radiation and oxidative stress. It comes as no surprise that replisomes frequently stall and dissociate because of encounters with DNA damage or tightly-bound protein-DNA complexes. In bacteria, such genomic instability can result in the genetic changes that drive antibiotic resistance evolution. Genomic stability is maintained through pathways that ensure continued replication by minimising the frequency or impact of collisions and identifying and repairing stalled forks. The methodologically diverse toolkit of single-molecule biophysics has been used to address a wide range of questions related to complex protein machineries. Specifically, this thesis highlights the application of single-molecule fluorescence methods to visualize and characterize DNA and the proteins that interact with it. In addition, it describes methodological advances that have been made to utilize linear DNA substrates to uncover protein dynamics. The overall goal of the projects described in this thesis was to design protocols and workflows for the production of linear DNA substrates which are (1) easily customizable to adjust for different experimental parameters and (2) which could be utilized to address a diverse range of biological questions, with a key focus on the controlled introduction of specific chemical lesions. This protocol was employed in support of answering a specific question: How do polymerase exchange dynamics affect lesion bypass mechanisms? This thesis focuses on the protein dynamics that occur at the replication fork in the context of roadblocks and lesions. For the first time, we observe replisome collisions with site-specific cyclobutane pyrimidine dimer lesions on linear substrates at the single-molecule level. This assay presents an exciting avenue to unveil further details of replication stalling and restart. Furthermore, this assay can be adapted to introduce a diverse range of roadblocks, to study dynamics of repair proteins at replication forks and observe the behavior of other replisome complexes. Classical biochemical and single-molecule techniques have provided insight into the proteins and macromolecular complexes responsible for rescue of stalled DNA replication forks. While the majority of studies have employed a reductionist approach in focusing on functions of isolated enzymes, recent work has started to explore the reconstitution of multiple-protein complexes of replication and repair pathways on single molecules of DNA. As we gain more knowledge of the dynamics and mechanisms observed at the single-molecule level, we will see emerging a more detailed picture of the molecular steps associated with the rescue stalled forks. This thesis represents an important step towards that more refined understanding

On twisted group ring isomorphism problem for p-groups

In this article, we explore the problem of determining isomorphisms between the twisted complex group algebras of finite $p$-groups. This problem bears similarity to the classical group algebra isomorphism problem and has been recently examined by Margolis-Schnabel. Our focus lies on a specific invariant, referred to as the generalized corank, which relates to the twisted complex group algebra isomorphism problem. We provide a solution for non-abelian $p$-groups with generalized corank at most three

Wireless Sensor Networks for Fire Detection and Control

Due to current technological progress, the manufacturing of tiny and low price sensors became technically and economically feasible. Sensors can measure physical surroundings related to the environment and convert them into an electric signal. A huge quantity of these disposable sensors is networked to detect and monitor fire. This paper provides an analysis of utilisation of wireless sensor networks for fire detection and control

A Literature Review of Corporate Governance Reform in the UK: 1985 and Today

The thesis explores the corporate governance system of the UK. This is achieved by providing answers to the main research questions. First, what exactly is corporate governance and why is it a critical issue in the UK? Second, how did the corporate governance issue arise in the UK, and therefore rose after the passage of the Cadbury Report? Third, what formulate the good governance principles in the UK, and how have they changed with the passage of various committees as well ad-hoc reports? The study is a literature review involving critical analysis and documents evidence relating to each of the answer. The findings are consistent with the view that corporate governance system within the UK has reformed, making the system better. In the end, the thesis documents evidence by using annual reports of pre-Cadbury and post Cadbury period of a multinational UK based corporation

Evaluation of zinc application methods and integrated nutrient management on variation in growth, yield and yield contributing factors in wheat

Zinc is an important micro nutrient and plays an important role in improving the crop growth and productivity. Intensive agricultural practices due to rise in population have accelerated the use of chemical fertilizers which resulted in depletion of soil fertility. In this regard, a 2 year field experiment was conducted at Agricultural Research Farm of Lovely Professional University during rabi season in 2021-2022 and 2022-23 to examine the effect of different zinc application methods and integrated nutrient management on growth, yield and yield contributing factors on wheat. Three types of zinc application methods along with various levels of integrated nutrient management approaches were used for the study. The results revealed that a significant interaction between zinc application methods and integrated nutrient management practices was observed with dry matter accumulation (g/m2), Leaf area index, spikes/m2, spike length (cm), number of grains per spike and grain yield of wheat crop. Maximum improvement in grain yield (5.5 t/ha) was obtained when soil+foliar application of zinc was combined with 75% recommended dose of fertilizer + 2.5 t/ha farm yard manure + Zinc solubilizing bacteria. Additionally, these studies need to be repeated at many locations with various agro-climatic circumstances

FORMULATION AND EVALUATION OF ETORICOXIB MICROBEADS FOR SUSTAINED DRUG DELIVERY

Objective: The aim of the study was to develop novel drug design of etoricoxib microbeads for sustained drug delivery by oral route which reduces the dosing frequency. Etoricoxib is a NSAIDs commonly used by patients so to reduce the dosing frequency of drug administration the etoricoxib loaded microbeads were prepared. Methods: Formulations were prepared with sodium alginate and calcium chloride in different ratios by inotropic gelation technique and characterized by FTIR, drug entrapment efficiency, particle size, swelling Index and release profile. Results: The microbeads show that 3.86±0.28% of surface entrapment, drug content 87±0.35%, swelling Index was found to be 80.76. The IR spectrum shows stable character of etoricoxib in the microbeads and revealed an absence of drug polymer interaction. The prepared microbeads were spherical in shape and had a size range of 125±0.02to 165±0.18µm, the release of the drug was found to be 64.092±0.24 in F4 formulation among all formulation in 240 minutes which shows that the drug released by sustained effect and shows kinetic release mechanism the formulation F1 shows fickian diffusion and F2, F3 and F4 shows the super-case, transport which depends upon the loss of polymeric chain and the release of drug takes place. Conclusion: The formulation F4 was found to be the best among all the other formulation because the percentage yield was found to be 80.6% among all formulation.                                             Peer Review History: Received 1 January 2019;   Revised 8 February; Accepted 2 March, Available online 15 March 2019 Academic Editor: Dr. Jennifer Audu-Peter, University of Jos, Nigeria, [email protected] UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file:        Reviewer's Comments: Average Peer review marks at initial stage: 3.5/10 Average Peer review marks at publication stage: 7/10 Reviewer(s) detail: Dr. Iman Muhammad Higazy, National Research Center, Egypt, [email protected] Dr. Hatem Sameir Abbas, Al-Azhar University, Egypt, [email protected]  Similar Articles: DEVELOPMENT AND EVALUATION OF RITONAVIR HOLLOW MICROBALLOONS FOR FLOATING DRUG DELIVER

Functional outcomes of reverse distal femoral locking plate in the extra capsular fractures of proximal femur

Background: The optimal management of unstable proximal femoral fractures is controversial. In this prospective study, the functional outcomes of reverse distal femoral locking plate for the treatment of comminuted unstable proximal femoral fractures were assessed. Objectives were to study the functional outcomes of reverse locking plate in extra-capsular fractures of the proximal femur, with respect to quality of reduction, time to bony union, mobility achieved, complications of the procedure, secondary procedures performed (if any) and delayed complications like implant breakage, delayed union, non-union.Methods: 17 patients with unstable proximal femoral fractures were assessed and managed with reverse distal femur plates, and evaluated with X-ray, physical examination, Palmer and Parker mobility score.Results: Union was achieved in all the patients, with average time to union 6.43±1.18 months (range 3-12 months). There was one loosening of implant and wound breakdown, which was managed conservatively. One case of loosening of proximal screws was there, but the fracture united in 9 months with some varus angulation. Superficial infection occurred in one patient, which healed after debridement and IV antibiotics.Conclusions: Taking into consideration the simple surgical technique, good healing rate and minimum complications, it is strongly recommended to use reverse locked distal femoral plates for the management of proximal femoral fractures and further in lean patients, sum-muscular MIPPO should be attempted