Novel 1,2,4-triazole clubbed with 1,3,4-oxadiazole motifs as efficient antimicrobial agents from N-arylsydnone as synthon

1,2,4-Triazoles and 1,3,4-oxadiazoles independently are very important pharmacophores. In view of this, a new class of 1,2,4-triazole clubbed with 1,3,4-oxadiazole motifs have been prepared and characterized by IR, 1H NMR, 13C NMR and mass spectral analysis. Molecular docking of all the title compounds into S. aureus tyrosyl-tRNA synthetase (PDB: 1JIJ) and lanosterol 14α-demethylase complex with standard inhibitor Fluconazole (PDB: 3KHM) was performed which snugly fitted into the active site thus explaining their excellent inhibitory activity exhibiting their possible antibacterial and antifungal activity, respectively. Drug-likeliness, Drug score values and toxicity prediction analyses of all the title compounds have shown favourable values and these molecules belong to Class 4 and Class 5 categories which make them useful scaffolds. Interestingly, the compounds 7h, 7i, 7k, 7u and 7v have exhibited majestic antibacterial activity. Also, these compounds have shown antifungal activity against all pathogenic fungal strains with lower MIC value ranging from 0.50 - 4.00 µg/mL

Synthesis of 3-aryl-4-({2-[4-(6-substituted-coumarin-3-yl)-1,3-thiazol-2-yl]hydrazinylidene}methyl/ethyl)-sydnones using silica sulfuric acid and their antidiabetic, DNA cleavage activity

A novel one-pot synthesis of sydnones appended to coumarins (4a–r) via thiazole in presence of silica sulfuric acid as a heterogeneous catalyst is discussed. The use of low cost and reusable silica sulfuric acid as catalyst makes this process feasible and convenient. Further, the title compounds were screened for their α-amylase inhibition (antidiabetic) as well as DNA cleavage activities

C5-Alkyl-1,3,4-Oxadiazol-2-ones Undergo Dealkylation upon Nitrogen Insertion to Form 2H-1,2,4-Triazol-3-ones: Synthesis of 1,2,4-Triazol-3-one Hybrids with Triazolothiadiazoles and Triazolothiadiazines

The present study emphasizes on the dealklylation of 3-aryl-5-alkyl-2-oxo-Δ4-1,3,4-oxadiazoles when reacted with formamide resulting in the formation of 2-aryl-2H-1,2,4-triazol-3(4H)-ones as major product. Subsequent reactions of 2-aryl-2H-1,2,4-triazol-3(4H)-one gave triazolo3,4-b1,3,4thiadiazoles and triazolo3,4-b1,3,4thiadiazines derivatives incorporated with 1,2,4-triazol-3-one

Novel 1,2,4-triazole clubbed with 1,3,4-oxadiazole motifs as efficient antimicrobial agents from N-arylsydnone as synthon

1082-10961,2,4-Triazoles and 1,3,4-oxadiazoles independently are very important pharmacophores. In view of this, a new class of 1,2,4-triazole clubbed with 1,3,4-oxadiazole motifs have been prepared and characterized by IR, 1H NMR, 13C NMR and mass spectral analysis. Molecular docking of all the title compounds into S. aureus tyrosyl-tRNA synthetase (PDB: 1JIJ) and lanosterol 14α-demethylase complex with standard inhibitor Fluconazole (PDB: 3KHM) is performed which snugly fitted into the active site thus explaining their excellent inhibitory activity exhibiting their possible antibacterial and antifungal activity, respectively. Drug-likeliness, Drug score values and toxicity prediction analyses of all the title compounds have shown favourable values and these molecules belong to Class 4 and Class 5 categories which make them useful scaffolds. Interestingly, the compounds 7h, 7i, 7k, 7u and 7v have exhibited majestic antibacterial activity. Also, these compounds have shown antifungal activity against all pathogenic fungal strains with lower MIC value ranging from 0.50 - 4.00 μg/mL

Unlocking the Sciences: Collaborative Research with Community Engagement through Citizen Science

This presentation, "Scientists Everywhere," was part of a three-person panel on citizen science and academic libraries at the 2015 American Library Association annual meeting. The panel was organized by the Science and Technology Section of the Association of College and Research Libraries (ACRL) and co-sponsored in name only by the ACRL Instruction Section and the ACRL Health Sciences Interest Group.Adapted from a chapter in the book, Exploring Environmental Science with Children and Teens by Eileen G. Harrington (ALA Publications, 2014), this presentation provides an overview of citizen science programs in academic libraries. It outlines the benefits and challenges of citizen science programs, tips for developing and implementing a citizen science project, and possible avenues of collaboration for academic libraries with citizen science projects