ELEMENTARY PRINCIPALS’ PERCEPTIONS OF CULTURALLY RESPONSIVE TEACHING PRACTICES AND THE IDENTIFICATION OF AFRICAN AMERICAN STUDENTS IN GIFTED EDUCATION PROGRAMS

The quantitative study investigated the relationships between (a) principals’ reported knowledge and/or support of Cultural Responsive Teaching (CRT) practices, (b) the North Carolina Academically or Intellectually Gifted (AIG) standards, and (c) the proportionality of gifted enrollment for African American students in North Carolina. The literature review revealed that culturally responsive programs successfully identify students of color for gifted education placement. However, non-culturally responsive programs resulted in great amounts of disproportionality in gifted enrollment, limiting African American access to advanced curriculum and instruction. The study explored three research questions to assess relationships: 1) Is there a statistically significant relationship between principals’ reported knowledge and/or support of North Carolina AIG standards and a principals’ reported knowledge and/or support of culturally responsive teaching practices? 2) Is there a statistically significant relationship between principals who report purposeful and routine use of culturally responsive teaching practices and the proportionality of African American student enrollment in AIG? and 3) Is there a statistically significant relationship between principals’ reported knowledge and/or support of the North Carolina AIG standards and the proportionality of African American student enrollment in AIG? A correlational analysis revealed a positive statistical relationship between the three variables. Accordingly, strategies were recommended to educational leaders to increase awareness concerning the proportionality of African American students in gifted education

Use of Repeated Within-Subject Measures to Assess Infants’ Preference for Similar Others

Research employing single-choice paradigms in which an infant is asked to make a single choice between two puppets suggest that infants show a preference for prosocial others and those who are similar to themselves. However, the extent to which infants’ preference for similar others is stable is unknown, as are other factors within the paradigm that may influence infants’ choices. The purpose of this study (two experiments, N = 44 infants, aged 8–15 months) was to replicate and extend previous work by including (1) within-subject repeated measures and (2) an experimental manipulation of a plausible demand characteristic. Results for the first-choice trial indicated a majority of the infants did not choose the similar puppet. Results from the within-subject repeated trials also indicated that a majority of the infants did not choose the similar puppet but a majority did choose a puppet from the same side. The experimental manipulation of the demand characteristic showed no effect on infant puppet choices. These results suggest that a closer examination of the single-choice puppet paradigm for assessing infants’ social evaluation is warranted. These findings also support recommendations made by others, including publishing null findings, standardizing data collection and reporting methods, and examining individual differences by employing within-subject designs with repeated measures

The Innocent Bystander: A Scenario Based Study on the Impact of Leadership Gossip

The purpose of this study was to understand how witnessing workplace gossip between a supervisor and an employee in a hypothetical scenario impacts ratings of acceptability of gossip behavior, leader quality ratings, relationship quality, and future comfort with the leader. Data were gathered from 207 college students who read a scenario involving gossip, which varied in the target (about oneself or another) and the domain (about work or personal matters) and then responded to a series of questions about the scenario. Across all four scenarios, leaders received fairly unfavorable ratings for participating in gossip behavior. However, we did not find consistent main effects based on the target or domain and there were no significant interactions between domain and target. Limitations and practical implications are further discussed

Structural divergence creates new functional features in alphavirus genomes

Alphaviruses are mosquito-borne pathogens that cause human diseases ranging from debilitating arthritis to lethal encephalitis. Studies with Sindbis virus (SINV), which causes fever, rash, and arthralgia in humans, and Venezuelan equine encephalitis virus (VEEV), which causes encephalitis, have identified RNA structural elements that play key roles in replication and pathogenesis. However, a complete genomic structural profile has not been established for these viruses. We used the structural probing technique SHAPE-MaP to identify structured elements within the SINV and VEEV genomes. Our SHAPE-directed structural models recapitulate known RNA structures, while also identifying novel structural elements, including a new functional element in the nsP1 region of SINV whose disruption causes a defect in infectivity. Although RNA structural elements are important for multiple aspects of alphavirus biology, we found the majority of RNA structures were not conserved between SINV and VEEV. Our data suggest that alphavirus RNA genomes are highly divergent structurally despite similar genomic architecture and sequence conservation; still, RNA structural elements are critical to the viral life cycle. These findings reframe traditional assumptions about RNA structure and evolution: rather than structures being conserved, alphaviruses frequently evolve new structures that may shape interactions with host immune systems or co-evolve with viral proteins

Emergence of tissue-like mechanics from fibrous networks confined by close-packed cells

The viscoelasticity of the crosslinked semiflexible polymer networks—such as the internal cytoskeleton and the extracellular matrix—that provide shape and mechanical resistance against deformation is assumed to dominate tissue mechanics. However, the mechanical responses of soft tissues and semiflexible polymer gels differ in many respects. Tissues stiffen in compression but not in extension1,2,3,4,5, whereas semiflexible polymer networks soften in compression and stiffen in extension6,7. In shear deformation, semiflexible polymer gels stiffen with increasing strain, but tissues do not1,2,3,4,5,6,7,8. Here we use multiple experimental systems and a theoretical model to show that a combination of nonlinear polymer network elasticity and particle (cell) inclusions is essential to mimic tissue mechanics that cannot be reproduced by either biopolymer networks or colloidal particle systems alone. Tissue rheology emerges from an interplay between strain-stiffening polymer networks and volume-conserving cells within them. Polymer networks that soften in compression but stiffen in extension can be converted to materials that stiffen in compression but not in extension by including within the network either cells or inert particles to restrict the relaxation modes of the fibrous networks that surround them. Particle inclusions also suppress stiffening in shear deformation; when the particle volume fraction is low, they have little effect on the elasticity of the polymer networks. However, as the particles become more closely packed, the material switches from compression softening to compression stiffening. The emergence of an elastic response in these composite materials has implications for how tissue stiffness is altered in disease and can lead to cellular dysfunction9,10,11. Additionally, the findings could be used in the design of biomaterials with physiologically relevant mechanical properties

Combining in vitro and in ovo assays to screen for anti-cancer and anti-angiogenic effects of the leaf extracts of Mallotus cumingii Müll.Arg. (Euphorbiaceae)

Cancer treatment is often challenging and various interventions may have detrimental effects. Due to this, the development of less harmful alternatives such as herbal medicine is essential. The present study aims to determine the leaf phytoconstituents present and the bioactivities of Mallotus cumingii Müll.Arg against cancer cells through the utilization of MTT assay and anti-angiogenesis through CAM assay. The leaf extracts obtained three fractions namely, methanolic crude (MCME) extracts, hexane extracts (MCHE), and ethyl acetate extracts (MCEA), and was tested on HCT-116 for in vitro cytotoxicity, and blood vessel density and branching through in ovo CAM assay. Phytochemical analysis showed that the M. cumingii fractions contain phenolic compounds, terpenoids, cardiac glycosides, flavonoids, and saponins. For in vitro set-up, MCME of M. cumingii were separated into MCHE and MCEA partitions and were tested against HCT-116 and obtained an IC50 value of < 30 μg/mL, which is deemed active in cytotoxicity. For in ovo set-up, two concentrations of each extract were applied to the duck eggs. Blood vessel density and number of branching points were measured through the ImageJ analysis. All extracts exhibited antiangiogenic activity, either by decreasing blood vessel density or the number of branching points. Overall, the study demonstrates the potential of M. cumingii as a source of therapeutic agents

Incident adverse drug reactions in geriatric inpatients : a multicentred observational study

Background: Adverse drug reactions (ADRs) are common in older adults and frequently have serious clinical and economic consequences. This study was conducted as a feasibility study for a randomized control trial (RCT) that will investigate the efficacy of a software engine to optimize medications and reduce incident (in-hospital) ADRs. This study's objectives were to (i) establish current incident ADR rates across the six sites participating in the forthcoming RCT and (ii) assess whether incident ADRs are predictable. Methods: This was a multicentre, prospective observational study involving six European hospitals. Adults aged 65 years, hospitalized with an acute illness and on pharmacological treatment for three or more conditions were eligible for inclusion. Adverse events (AEs) were captured using a trigger list of 12 common ADRs. An AE was deemed an ADR when its association with an administered drug was adjudicated as being probable/certain, according to the World Health Organization Uppsala Monitoring Centre causality assessment. The proportion of patients experiencing at least one, probable/certain, incident ADR within 14 days of enrolment/discharge was recorded. Results: A total of 644 patients were recruited, evenly split by sex and overwhelmingly of White ethnicity. Over 80% of admissions were medical. The median number of chronic conditions was five (interquartile range 4-6), with eight or more conditions present in approximately 10%. The mean number of prescribed medications was 9.9 (standard deviation 3.8), which correlated strongly with the number of conditions (r = 0.54, p < 0.0001). A total of 732 AEs were recorded in 382 patients, of which 363 were incident. The majority of events were classified as probably or possibly drug related, with heterogeneity across sites (chi(2) = 88.567, df = 20, p value < 0.001). Out of 644 patients, 139 (21.6%; 95% confidence interval 18.5-25.0%) experienced an ADR. Serum electrolyte abnormalities were the most common ADR. The ADRROP (ADR Risk in Older People) and GerontoNet ADR risk scales correctly predicted ADR occurrence in 61% and 60% of patients, respectively. Conclusion: This feasibility study established the rates of incident ADRs across the six study sites. The ADR predictive power of ADRROP and GerontoNet ADR risk scales were limited in this population

DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice

In humans, DOCK8 immunodeficiency syndrome is characterized by severe cutaneous viral infections. Thus, CD8 T cell function may be compromised in the absence of DOCK8. In this study, by analyzing mutant mice and humans, we demonstrate a critical, intrinsic role for DOCK8 in peripheral CD8 T cell survival and function. DOCK8 mutation selectively diminished the abundance of circulating naive CD8 T cells in both species, and in DOCK8-deficient humans, most CD8 T cells displayed an exhausted CD45RA+CCR7? phenotype. Analyses in mice revealed the CD8 T cell abnormalities to be cell autonomous and primarily postthymic. DOCK8 mutant naive CD8 T cells had a shorter lifespan and, upon encounter with antigen on dendritic cells, exhibited poor LFA-1 synaptic polarization and a delay in the first cell division. Although DOCK8 mutant T cells underwent near-normal primary clonal expansion after primary infection with recombinant influenza virus in vivo, they showed greatly reduced memory cell persistence and recall. These findings highlight a key role for DOCK8 in the survival and function of human and mouse CD8 T cells

Introductory programming: a systematic literature review

As computing becomes a mainstream discipline embedded in the school curriculum and acts as an enabler for an increasing range of academic disciplines in higher education, the literature on introductory programming is growing. Although there have been several reviews that focus on specific aspects of introductory programming, there has been no broad overview of the literature exploring recent trends across the breadth of introductory programming. This paper is the report of an ITiCSE working group that conducted a systematic review in order to gain an overview of the introductory programming literature. Partitioning the literature into papers addressing the student, teaching, the curriculum, and assessment, we explore trends, highlight advances in knowledge over the past 15 years, and indicate possible directions for future research