‘That eccentric use of land at the top of the hill’: Cemeteries and stories of the city

Most contemporary research accounts for conflict within cemetery space, but does not consider the potentially contested and poorly understood role of cemeteries within their broader cityscape. This study draws on stories from cemetery managers across England and Wales to narrate this multifunctionality, as they hold the pivotal role which oversees both the day-to-day running of the cemetery, and its strategic role within a given municipality. The study outlines how cemeteries hold multiple functions in the cities in which they are located, specifically contributing to greenspace or green infrastructure, civic identity and local place attachment. These varying city level roles in turn impact on what is deemed (il)legitimate behaviour within the cemetery. Moreover, they raise important considerations for urban planners and policymakers who currently have little guidance on planning for new or existing cemeteries but are critical in the ongoing successful development of cities

Rapid copper acquisition by developing murine mesothelioma: Decreasing bioavailable copper slows tumor growth, normalizes vessels and promotes T cell infiltration

Copper, an essential trace element acquired through nutrition, is an important co-factor for pro-angiogenic factors including vascular endothelial growth factor (VEGF). Decreasing bioavailable copper has been used as an antiangiogenic and anti-cancer strategy with promising results. However, the role of copper and its potential as a therapy in mesothelioma is not yet well understood. Therefore, we monitored copper levels in progressing murine mesothelioma tumors and analyzed the effects of lowering bioavailable copper. Copper levels in tumors and organs were assayed using atomic absorption spectrophotometry. Mesothelioma tumors rapidly sequestered copper at early stages of development, the copper was then dispersed throughout growing tumor tissues. These data imply that copper uptake may play an important role in early tumor development. Lowering bioavailable copper using the copper chelators, penicillamine, trientine or tetrathiomolybdate, slowed in vivo mesothelioma growth but did not provide any cures similar to using cisplatin chemotherapy or anti-VEGF receptor antibody therapy. The impact of copper lowering on tumor blood vessels and tumor infiltrating T cells was measured using flow cytometry and confocal microscopy. Copper lowering was associated with reduced tumor vessel diameter, reduced endothelial cell proliferation (reduced Ki67 expression) and lower surface ICAM/CD54 expression implying reduced endothelial cell activation, in a process similar to endothelial normalization. Copper lowering was also associated with a CD4+ T cell infiltrate. In conclusion, these data suggest copper lowering is a potentially useful anti-mesothelioma treatment strategy that slows tumor growth to provide a window of opportunity for inclusion of other treatment modalities to improve patient outcomes

‘They have different ways of doing things’: Cemeteries, diversity and local place attachment

This paper explores how local place attachment and group identity are conceived by those who manage civic cemeteries, and those who, by their memorial practices, co-create them. Engaging with debates about (post)colonialism and belonging, the paper presents evidence from both interviews and photographs, conceptually framing the meaning of these with reference to Lefebvre’s spatial triad: of space as perceived, conceived and lived. It identifies a disjuncture between the way cemetery managers view group and individual identities, and the way this manifests in memorial practices. Formal ‘representations of space’ are influenced by neo-colonial narratives of ‘insiders’ and ‘outsiders’ whereas greater diversity and categorical transgressions are apparent in spatial practices. This has implications for the management and articulation civic identity and contemporary understandings of belonging beyond as well as within public places of memorial and remembrance