1,155 research outputs found

    Senior Recital: Katie Adams, double bass

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    Enabling organizational strategy through effective capital programming

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    Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Civil and Environmental Engineering, 2000.Vita.Includes bibliographical references (leaves 128-131).America's infrastructure assets are in a state of decay. There are too many needs with too few funds available for investment. Exacerbating the problem is the continuing decline of government infrastructure appropriations and poor public infrastructure management techniques. This thesis proposes the integration of organizational strategy and capital programming to produce an efficient infrastructure portfolio able to be financially managed by the owner agency. The strategic capital programming process aims to enable the owner agency to base investment decisions on prior agency performance, long-term agency goals, and realistic analyses of market trends. The iterative process incorporates six core steps: 1) an audit of the agency's past performance, 2) a strategic assessment of the agency's goals and market environment concluding with the development of a corresponding list of potential capital projects, 3) the compilation of a baseline resource profile of the portfolio of projects, 4) an iterative portfolio analysis of the capital projects using schedule, scope, delivery method, and financing as variables, 5) the choice of a capital program that most closely fits agency resource constraints and strategic goals, and 6) program execution, performance tracking, and feedback. There are three major advantages to implementing a capital programming process that is focused on achieving strategic agency goals through the use of performance analysis and variable project delivery strategies. The process results in an effective and efficient long-term infrastructure investment strategy. Through the use of the process, the agency enables the achievement of their goals rather than hindering them with poor management methods. Finally, the agency can satisfy public demand by becoming more accountable for their investment of funds and strategic decision-making due to increased stakeholder participation and market analysis in the programming process. This thesis presents a detailed description and analysis of a strategic capital programming model and its applicability to government agencies. A case study of the Massachusetts Port Authority compares the proposed process to capital programming processes currently in use in advanced government agencies. The case study validates the inclusion of agency audit and strategic programming processes in capital programming and establishes the need for a new standard of market- and performance- oriented decision-making incorporating increased communication and feedback within the organization.by Katie J. Adams.S.M

    Genetic Structure of Grass Carp Populations in the Missouri and Mississippi River Basins, USA

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    We provided an early characterization of the genetic structure of the grass carp (Ctenopharyngodon idella) population as it expands its distribution in both the Missouri and Mississippi River basins. Further, we provided initial comparisons of allelic richness at 17 polymorphic microsatellite markers between 56 grass carp from the USA, and six from the Yangtze River in China. The number of alleles per locus ranged from two to eight and size ranges of alleles for fish collected from the invaded and native ranges were similar (P ≤ 0.001; 107–226 bp) to those previously reported in the literature. Distance-based clustering methods did not suggest significant groupings by river reaches. Using allele frequencies, we identified a possible population bottleneck (heterozygosity excess in the Missouri River upstream sample group) between the uppermost Missouri River reach and all other samples which may indicate a difference in the level of diversity between the locations. Within population allelic diversity (AS) was 1.56, 2.27, and 1.39 for samples from the Missouri River in South Dakota and Nebraska, samples from the Missouri River in Missouri, and samples from the Mississippi River respectively. Despite isolation from the native population and exposure to a novel environment, in the nearly 50 years since their first introduction from China, the genome at these 17 microsatellite loci has diverged little from fish collected in their native range. We found only weak evidence to suggest that grass carp throughout the Missouri and upper Mississippi River basins are reproductively isolated from one another at this time. Range expansion can result in divergent genetic structure of subpopulations, which may provide clues about the mechanism of invasion success and inform fisheries scientists how to focus management efforts most effectively. These results provided a unique glimpse at a species early in the process of range expansion in the USA and provide a benchmark for future assessments of grass carp genetic structure in the Great Plains

    Monocyte and Cytokine Responses are improved by Baker’s Yeast β-Glucan Supplementation following Exercise in a Hot, Humid Environment

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    Strenuous exercise is known to suppress the immune system, which can increase the chances of getting sick in the hours after exercise. The purpose of this study was to determine if 10-d of supplementation with yeast b-glucan alters monocyte concentration, LPS-stimulated cytokine production, and plasma cytokine concentration in recreationally active subjects. Recreationally active subjects (29 men, 31 women, 22±4 y) completed 49±6 min of cycling (37±2°C, 45±5% relative humidity) after consuming either yeast b-glucan (250 mg/d, BG) or a placebo (sugar pill, PL) for 10-days prior to each exercise session. The investigators were blinded to the supplement conditions until all data was collected and analyzed. Venous blood was collected at baseline (prior to supplement), pre-, post-, and 2-hours (2H) post exercise. Total and subset monocyte concentration was measured by flow cytometry. LPS-stimulated production of 12 cytokines was measured using a whole blood assay. Plasma concentration of 13 cytokines was measured using a high-sensitivity MagPix assay. Monocyte (CD14+) concentration was significantly greater at 2H (P=0.05) with BG. Also, compared to PL, BG boosted LPS-stimulated production IL-2, IL-4, IL-5, and IFN-g at PRE and POST (P\u3c0.05). Plasma concentration of IL-2, IL-4, IL-5, IL-7, IL-10, and IFN-g were significantly greater at 2H in the BG compared to PL. In the placebo condition we observed the traditional response to strenuous exercise (rise at POST and suppression at 2H). It appears that 10-days of supplementation with BG primed blood leukocytes for the production of IL-2, IL-4, IL-5, and IFN-g. These cytokines were elevated prior to and immediately after exercise in LPS-stimulated cultures and subsequent elevation were observed at 2H with unstimulated plasma measures. In addition to cytokine changes, BG appeared to blunt post-exercise reduction in blood monocyte concentration, which may have implication of immune-surveillance. The key findings of the present study demonstrate that BG may be a suitable countermeasure to protect and boost the immune system following stressful exercise. Such boost is likely to lower the duration of the “open window” response. This study was funded by Biothera, The Immune Health Company

    Archives Magazine

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    The first issue of The Archives Magazine, a student project, in cooperation with the Profesional Writing Program of the English Department at Kutztown University. The scope of this publication is the history of Kutztown University of Pennsylvania

    2010 Ruby Yearbook

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    A digitized copy of the 2010 Ruby, the Ursinus College yearbook.https://digitalcommons.ursinus.edu/ruby/1113/thumbnail.jp
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