Implementación de un sistema de inocuidad en la producción de tabletas de chocolate para taza

Universidad Nacional Agraria La Molina. Facultad de Industrias Alimentarias. Departamento Académico de Ingeniería de Alimentos y Productos AgropecuariosEl presente trabajo representa el esfuerzo del Área de Calidad por implementar y mantener vigente el Sistema de Gestión de Inocuidad en la empresa La Monarca S.A., encargada de elaborar tabletas de chocolate para taza. Se describe el proceso de implementación iniciando con un diagnóstico, el cual recolecta el estado en que se encontró la empresa antes de la implementación y las oportunidades de mejora a realizar durante la implementación, con la elaboración de manuales prerrequisitos (Manual de Buenas Prácticas de Manufactura y Plan de Higiene y Saneamiento) y Sistema de Análisis de Peligros y Puntos Críticos de Control (HACCP) para la producción de chocolates para taza. Como etapa final del proceso de implementación se realizó capacitaciones al personal, ejercicios de rastreabilidad, auditorías internas, entre otros. El resultado final de la implementación del sistema de inocuidad fue la obtención de la certificación del Sistema de Análisis de Peligros y Puntos críticos de control (HACCP) para la línea de chocolates para taza mediante auditoría externa, a cargo de la empresa FSC Certificaciones, con una duración de un año con opción a renovación.This manuscript represents the effort of the quality area to implement and maintain the safety management system in force in the company La Monarca S.A., in charge of making chocolate bars for cups. The implementation process was described, starting with a diagnosis, which collects the state in which the company was found before implementation and the opportunities for improvement to be made during implementation, with the preparation of prerequisite manuals (Manual of good Manufacturing Practices and Hygiene and Sanitation Plan) and Hazard Analysis System and Critical Control Points (HACCP) to produce chocolate cups. As a final stage of the implementation process, staff training, traceability exercises, internal audits, among others, were carried out. The result of the implementation of the safety system was the obtaining of the certification of the Hazard Analysis System and Critical Control Points (HACCP) for the line of chocolate for cups through external audit, by the company FSC Certificaciones, with a duration of one year with the option of renewal

What do secondary teachers think about digital games for learning : Stupid fixation or the future of education?

Digital games can support learning across many levels and fields of education. This article shares findings from a study of Australian high school English teachers designed with a mixed response questionnaire about using digital games in the classroom. The findings identified polarised teacher perspectives on the role of gaming in formal curriculum, tension in teachers’ ideal and enacted use of digital games, and a need for in-practice professional development on digital games. Implications include the need to optimise digital games use for learning in teaching and teacher education, and to address perceptions on the validity of gaming for classroom learning

Video gaming and digital competence among elementary school students

Engagement with video games can potentially advance student digital competence however, there is a digital skills gap by the time young people progress into adolescence. This current research explores how elementary school students’ digital self-efficacy might relate to experiences in video game environments to influence perceptions of digital competence. We examine the differential impact of sex, self-efficacy, and socioeconomic status (SES) on 7–10-year-old students’ (N = 613) perceptions of video gaming and their digital skills. Analysis revealed the unexpected finding that SES was inversely related to enjoyment for gaming and digital technology, with students in the lower-SES category responding more positively compared to students in higher SES categories. As expected, boys self-reported digital skills higher than girls across all SES categories. We argue for the use of gaming pedagogies to support learning in classrooms that accounts for nuances in students’ digital self-efficacy moderated by gender and SES

Factors Affecting Quality of Life for Children with Asthma

BACKGROUND: In the U.S., asthma is the most common chronic illness in children under 18 years. An exploration of asthma admission rates in emergency departments indicated this was also the case for Southeast Georgia. Despite the availability of effective asthma treatments and interventions, asthma continues to severely impact children’s health-related QOL. PURPOSE: This exploratory study sought to assess quality of life (QOL) issues facing children with asthma and their caregivers. Specifically, this study aimed to 1) Determine the baseline QOL in children with asthma and their parents/caregivers, & 2) Determine what factors affect QOL for children with asthma and their caregivers. METHODS: This exploratory study employed a mixed-model design. Participants were recruited for a convenience sample from a large children’s hospital outpatient clinic in Southeast Georgia. Participants included children aged 7-17 with a diagnosis of asthma or reactive airway disease (N=104) and their parents/caregivers (N=104). Child participants completed the Paediatric Asthma Quality of Life Questionnaire (PAQLQ), a reliable and validated QOL questionnaire for childhood asthma focusing on the domains of activity limitations, emotional function, and an exploration of symptoms. Caregiver participants completed a demographics questionnaire and the Paediatric Asthma Caregiver’s Quality of Life Questionnaire (PACQLQ), a reliable and validated QOL questionnaire for caregivers of children with childhood asthma focusing on two domains, activity limitations and emotional function. Items in both the PAQLQ and PACQLQ questionnaires are rated on a 7-point scale, with higher scores indicating less impairment and lower scores indicating greater impairment to the domain under consideration. RESULTS & CLINICAL IMPLICATIONS: In addressing the first aim of this study, the results revealed that the baseline QOL for children with asthma and their caregivers was relatively high. In addressing the second aim of this study, the results of both the PAQLQ and the PACQLQ revealed that the most significant factor that affects the QOL of children with asthma is ED visits. The more ED visits reported, the greater the impairment to emotional function and physical activity. While the findings of this study demonstrate a positive baseline QOL, it is important to further investigate the specific impact of ED visits on QOL of children with asthma and their caregivers. An important clinical implication is that education on controlling asthma symptoms to prevent ED visits for both children and their caregivers may be of value to improve their QOL

GABB : A global dataset of alpine breeding birds and their ecological traits

Alpine ecosystems represent varied climates and vegetation structures globally, with the potential to support rich and functionally diverse avian communities. High mountain habitats and species are under significant threat from climate change and other anthropogenic factors. Yet, no global database of alpine birds exists, with most mountain systems lacking basic information on species breeding in alpine habitats, their status and trends, or potential cryptic diversity (i.e., sub-species distributions). To address these critical knowledge gaps, we combined published literature, regional monitoring schemes, and expert knowledge from often inaccessible, data-deficient mountain ranges to develop a global list of alpine breeding bird species with their associated distributions and select ecological traits. This dataset compiles alpine breeding records for 1,310 birds, representing 12.0% of extant species and covering all major mountain regions across each continent, excluding Antarctica. The Global Alpine Breeding Bird dataset (GABB) is an essential resource for research on the ecological and evolutionary factors shaping alpine communities, as well as documenting the value of these high elevation, climate-sensitive habitats for conserving biodiversity.Peer reviewe

Comparative Gene Expression Analysis throughout the Life Cycle of Leishmania braziliensis: Diversity of Expression Profiles among Clinical Isolates

Leishmania is a group of parasites (Protozoa, Trypanosomatidae) responsible for a wide spectrum of clinical forms. Among the factors explaining this phenotypic polymorphism, parasite features are important contributors. One approach to identify them consists in characterizing the gene expression profiles throughout the life cycle. In a recent study, the transcriptome of 3 Leishmania species was compared and this revealed species-specific differences, albeit in a low number. A key issue, however, is to ensure that the observed differences are indeed species-specific and not specific of the strains selected for representing the species. In order to illustrate the relevance of this concern, we analyzed here the gene expression profiles of 5 clinical isolates of L. braziliensis at seven time points of the life cycle. Our results clearly illustrate the unique character of each isolate in terms of gene expression dynamics: one Leishmania strain is not necessarily representative of a given species

Private information arrival, trading activity, and price formation: Evidence from nonpublic merger negotiations

Abstract: We provide evidence on how stock prices and trading activity respond to the arrival of private information about firm value using the dates of material nonpublic merger negotiations to proxy for private information arrival. Target firm returns are 0.41% higher over two days following each nonpublic negotiation event. Trading volume, order imbalance, and trade size also spike in this window. Larger price reactions following negotiation events preempt deal announcement returns. The price response following negotiation events is explained by proxies for the expected profits and price impact of informed trading, prior press speculation, institutional ownership, and contemporaneous trading activity signals. We thank Linda Bamber, Diane Del Guercio, Ro Gutierrez, Kathy Kahle, Ron Kaniel, Eric Kelley, Chris Lamoureux, Jochen Lawrenz, Lubo Litov, Wayne Mikkelson, Bill Schwert, Rick Sias, Jerry Warner, and workshop participants at MIT, and the Universities of Arizona, Georgia, Innsbruck, Oregon, Rochester, and Utah for helpful comments. We are also grateful to Denis Sosyura (discussant) and participants at the 2012 University of Washington Summer Finance Conference. We recognize the excellent research assistance provided by Tyler Brough, Michael Dambra, Douglas Fairhurst, Jordan Neyland, and Matthew Serfling. * Rochester, NY 14627; phone: 585.273.4818; email: [email protected] ** Tucson, AZ 85721; phone: 520.621.8761; email: [email protected] 1 Understanding the degree to which investors rapidly acquire and trade on new private information about firm value and how their trades affect price formation is central to the design of securities regulation and inferences about the efficiency of financial markets. The evidence in a number of recent studies shows that informed investors obtain private information in a variety of ways, such as through connections to insiders, and that they use this information to make profitable trades. For instance, To infer private information-based trades, the aforementioned studies often begin with a firm's disclosure of earnings or the announcement of a merger agreement and examine trading behavior and price movements over a brief window before the disclosure. But, ascertaining whether connected investors trade on private information is challenging in part due to the difficulty of tying stock returns and trading decisions to the underlying arrival of private information. Because securities regulation does not generally compel managers to disclose material nonpublic information immediately, traders can acquire and exploit private information weeks or months before the firm is required to disclose it. In this paper we study underlying events that produce and distribute private information about the value of a firm. Specifically, we use the dates of merger negotiations that occur privately, but are disclosed weeks or months after the deal is announced, to more precisely identify when private information is actually generated. These data allow us to examine whether informed investors promptly trade on private information that arrives during the course of merger 2 negotiations and if their trading has an economically important effect on target firms' stock prices. 1 For a sample of 545 completed acquisitions announced between 1995 and 2006, we use Securities and Exchange Commission (SEC)-mandated background disclosures to identify the dates and types of various material "events" that occur during negotiations between the target and potential acquirers before an acquisition deal is announced. These nonpublic negotiation events include, for example, the initiation of merger talks, a bidder making a private offer for the target, the retention of a financial advisor, or a meeting of the target's board to evaluate a proposed deal. On average, over the three months prior to the merging parties' disclosure of a preliminary merger agreement (hereafter, referred to as the deal announcement), there are about seven unique trading days during which at least one material negotiation event occurs. After controlling for the impact of press speculation about a potential acquisition deal (which affects 18% of the deals in our sample) we find that for each nonpublic negotiation event, target firm excess abnormal returns average 0.18% the same day and 0.23% the day after the event, resulting in a two-day estimated excess return of 0.41%. These returns are incremental to the average positive abnormal returns during the negotiation period and thus provide a lower-bound estimate of the price impact of trading on private information about merger negotiations. To more fully understand the source of these returns, we examine whether non-price measures of informed trading are also related to the arrival of private information during merger negotiations. We document significant spikes in abnormal trading volume, buyer-initiated transactions measured by order imbalance, and medium-size trades over the two-day window following a nonpublic negotiation event. Moreover, we also find that increases in contemporaneous 1 Informed trading before a merger announcement includes both illegal insider trading on material nonpublic information and legitimate trading based on superior information acquisition and processing. Moreover, the term "insider" in insider trading as used in this paper refers to any individual that knowingly trades on material nonpublic information. This could include, but is not limited to, corporate insiders as defined under Section 16 requirements for reporting trades (e.g., officers, directors, and some blockholders). See Agrawal and Jaffe (1995) and Agrawal and Nasser (2012) for evidence on trading by corporate insiders prior to merger announcements. 3 volume, buy-sell order imbalance, and medium-size trades predict stock returns following negotiation events. For example, a ten percentage point increase in abnormal trading volume is associated with a 12 basis point larger stock price reaction to each negotiation event. These effects are incremental to the typical effect of trading activity on stock returns and suggest that the arrival of private information about merger negotiations has substantive implications for understanding the trading decisions of informed investors and the informational efficiency of stock prices. Next, we investigate whether firm and deal-specific factors explain how quickly target stock prices respond to the arrival of private information. We show that stock returns following negotiation events are increasing in both the expected profits from trading on private information, as measured by the offer premium, and the likelihood of deal completion, captured by a tender offer or target termination fee clause. We further document that the magnitude of the stock price response is increasing in the adverse selection costs of trading in the target firm's shares, proxied by PIN (probability of informed trading) and low analyst coverage. In other words, stock returns are more sensitive to negotiation events for firms whose stock price is generally more sensitive to informed trades. We also find that higher institutional ownership is associated with a decrease in the sensitivity of stock returns to negotiation events. This evidence suggests that institutions may be less willing than individuals to trade on private information from negotiation events or that if they do trade on this information, they do not do so immediately after a negotiation event. We also examine whether media speculation about a deal is related to the sensitivity of target firm stock returns to nonpublic negotiation events. Controlling for the market's reaction to a rumor, we show that for the 18% of the deals in our sample with at least one published rumor prior to the deal announcement, the target firm's stock returns respond significantly more to negotiation events. Further, we document that this effect is most pronounced for nonpublic negotiation events that occur after the rumor is published. These findings are consistent with the conventional wisdom that 4 the litigation risk from trading on private information is decreasing in the amount of existing public information about a potential deal and with the notion that because press speculation increases target firms' stock return volatility, news rumors make it easier for informed investors to trade without detection from other traders. We investigate the factors that determine the timing and occurrence of press speculation. Indicating that private information from merger negotiations is in some instances quickly leaked to the media, we show that although press rumors tend to follow observable abnormal stock returns and trading volume, they are incrementally more likely to take place over the two days following a nonpublic negotiation event. Further, implying that informed investors are potentially responsible for at least some of this leakage, we find that a deal is more likely to be rumored when the set of investors with private information about deal negotiations is larger, proxied for with measures for the number of deal insiders (Acharya and Johnson One interpretation of this finding is that, at times, informed investors intentionally leak some of their private information to the press so they can more easily trade on the remainder of their information. To further assess the economic importance of informed trading following the arrival of private information, we examine the extent to which the price impact of this trading affects the target's acquisition price and the market's reaction to the announcement of a merger agreement. Schwert's (1996) evidence suggests that for every 1 increase in the target's stock price prior to the deal announcement, the target negotiates more than a 1 increase in the final acquisition price from the acquirer. However, acquirers and targets know the dates they negotiated, and thus, acquirers should be able to discount stock price movements occurring just after negotiation events. Our results suggest that a $1 increase in stock price attributable to informed trading following nonpublic negotiation events leads to a$0.81 increase in the final transaction price, a significant 29% discount from the $1.14 increase in the final transaction price for each$1 of non-event price increase. In 5 other words, deal negotiators place a lower weight on stock returns linked to nonpublic negotiation event days than stock returns on other days. We also find that a one percent increase in the target's stock price attributable to informed trading following nonpublic negotiation events reduces the market's reaction to the deal announcement by 26 basis points. However, a similar one percent increase in stock price during the period prior to the deal announcement that is not attributable to negotiation events reduces the market's reaction by only 13 basis points. These findings imply that private information-based trading following merger negotiations is economically important in preempting the information in the deal announcement. Our study contributes to the literature that considers how public and private information impacts trading decisions and price formation. We use a novel but intuitive approach to provide insights on private information-based trading and its impact on price formation by focusing on the dates when private information is created. Our evidence indicates that well-informed traders rapidly exploit their information advantage. Their trades are reflected in volume, order flow, and trade size, and have an economically important effect on a firm's stock price. Further, we identify several factors that determine the magnitude of the stock price reaction to the arrival of private information during merger negotiations. The stock price reaction depends on contemporaneous volume and order flow, expected profits from trading on private information, the expected price impact of informed trading, institutional ownership, and whether a private negotiation event is preceded by press speculation. Implying that informed trading following merger negotiations preempts information in the deal announcement, we also show that stock returns linked to days with private information events are associated with significantly smaller deal announcement returns. This study also contributes to the emerging literature on how traders' characteristics and connections to insiders impact the timing and profitability of their trades and the efficiency of stock 6 prices. Our focus on days when information is produced and distributed provides an avenue for future research to examine how the trades of specific investors correlate with the arrival of private information. Given that we document trading activity and stock returns respond quickly to the arrival of new private information about firm value, our evidence also speaks to the SEC's focus on hedge funds, brokerages, deal advisers, and exchange traders and their access to and use of confidential inside information. The remainder of the paper is organized as follows. Section 1 reviews prior work on private information-based trading and discusses the potential for such trading activity subsequent to merger negotiations. Section 2 presents our empirical results. Section 3 concludes. Informed Trading and the Timing of Nonpublic Merger Negotiations Asymmetric information is a pervasive trait of capital markets. The intent of disclosure regulation is to ensure that material information is disclosed to investors, but there are few mandatory obligations for real-time disclosure of new information. As a result, stock prices can diverge from their full information value. Public disclosure of material nonpublic information may be delayed for weeks or even months, thereby providing incentives for traders to uncover private information. Traders with more precise information about a firm's value are more likely to trade on their information. In the absence of public disclosure of new information, the speed at which price converges to its full information value depends on informed trading. Profit-maximizing informed traders have incentives to camouflage their trades by spreading them out over time As the number of privately-informed investors grows, competition between them can create incentives to trade more aggressively, leading to more efficient prices (Holden and Subrahmanyam 7 (1992)). In contrast, 2 We focus on the timing of nonpublic merger negotiations to identify informed trading activity and its effect on price formation. 3 An informed investor's trading incentives depend on how negotiations progress, the expected offer price relative to the current price (the premium), and the likelihood of a successful deal. The distribution of that private information during negotiations also matters. The initial contact between the merging parties is often between CEOs and a few close advisors and directors. As discussions progress, the target's (and often the acquirer's) entire board is informed, financial and legal advisors are retained, investment bankers are contacted to assist with financing, and lower-level managers and auditors are brought in to support the due diligence process and integration planning. While the negotiating managers, directors, advisors, and financing 2 Prior studies that attempt to link trading on private information prior to acquisitions with target stock price formation look at the magnitude of stock price runups in acquisition targets 5 4 Expert networks are one of the interesting targets of recent insider trading investigations. Expert networks retain current and past managers and other industry specialists as consultants to investors such as mutual funds and hedge funds. While expert network firms have policies that bar their consultants from passing along confidential information, it appears that many consultants have done so. A recent complaint filed by the SEC alleges that ten consultants and one investment advisor working for the expert network firm Primary Global Research (PGR) passed along material nonpublic information to hedge funds and other PGR clients in exchange for cash compensation. The SEC alleges that the clients of PGR earned about $30 million in illicit profits as a result (SEC vs. Longria et a