Mean arterial pressure in response to chronic intramedullary blockade of ET-B receptors.

<p>Chronic intramedullary blockade of ET-B receptors causes a slight increase in MAP in rats on a normal salt diet (112.8±2.4 in vehicle vs. 120.7±9.3). However, rats placed on high salt diet had a much greater elevation in MAP in response to IM ET-B blockade (123.7±3.2 vs. 164.2±7.1). * denotes p<.05 vs. all other groups.</p

Renal medullary tissue levels of 20-HETE in response to blockade of medullary ET-B receptors.

<p>In response to increasing salt intake in male SD rats, renal medullary 20-HETE levels are significantly elevated (5.6±0.75 vs. 14.3±3.7, n = 4 and n = 7 respectively). With chronic intramedullary blockade of ET-B receptors, this response is completely abolished (4.9±0.79 vs. 4.5±0.55, n = 5 and n = 6 respectively). * denotes p<.05 vs. NS + VEH.</p

Mean arterial pressure in rats with intramedullary blockade of ET-B receptors in the presence and absence of a 20-HETE inhibitor.

<p><b>A</b>) This figure illustrates the changes in blood pressure in response to chronic intramedullary infusion of the ET-B antagonist, A-192621, the 20-HETE inhibitor, HET0016, and rats pretreated with HET0016, and then administered A-192621. <b>B</b>) Illustrates that the increase in blood pressure in response to intramedullary blockade of ET-B receptors is blunted when the rats are pretreated with a 20-HETE inhibitor. *indicates that p<0.05 vs. A-192621 treated group.</p