14 research outputs found
d-Methionine protects against cisplatin-induced neurotoxicity in cortical networks
- Author
- Al-Khatib
- Bibesh Shrestha
- Brock
- Calvin Wu
- Campbell
- Campbell
- Campbell
- Campbell
- Church
- Cloven
- Deegan
- Dehne
- Eastman
- Einarsson
- Ekborn
- Ernest J. Moore
- Gabaizadeh
- Gandara
- Gopal
- Gopal
- Gopal
- Gross
- Gross
- Gross
- Gross
- Gross
- Gross
- Gross
- Guenter W. Gross
- Hamstra
- Hansen
- Hoistad
- Jamieson
- Jiang
- Johnstone
- Jones
- Jones
- Kaasa
- Kamakshi V. Gopal
- Kathleen C.M. Campbell
- Keefer
- Keefer
- Knight
- Knight
- Kolinsky
- Kovarík
- Lauenstein
- Lynch
- McWhinney
- Meech
- Morefield
- Muldoon
- Namikawa
- Novellino
- Olivi
- Orgel
- Otto
- Parviz
- Poirrier
- Potter
- Rajeswaran
- Reser
- Rijal-Oli
- Rybak
- Rybak
- Stathopoulos
- Vuyyuri
- Whitney
- Wimmer
- Wu
- Xia
- Publication venue
- 'Elsevier BV'
- Publication date
- 23/06/2012
- Field of study
Article discussing D-Methionine protecting against cisplatin-induced neurotoxicity in cortical networks
Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus
- Author
- Adenis C. (Claude)
- Aittomäki K. (Kristiina)
- Andrulis I.L. (Irene)
- Anton-Culver H. (Hoda)
- Antoniou A.C. (Antonis)
- Arndt V. (Volker)
- Arun B.K. (Banu)
- Arver B. (Brita Wasteson)
- Asperen C.J. (Christi) van
- Ausems M.G.E.M. (Margreet)
- Bandera E.V. (Elisa)
- Barile M. (Monica)
- Barjhoux L. (Laure)
- Barkardottir R.B. (Rosa B.)
- Barouk-Simonet E. (Emmanuelle)
- Barrowdale D. (Daniel)
- Barwell J. (Julian)
- Baurand A. (Amandine)
- Beckmann M.W. (Matthias)
- Beesley J. (Jonathan)
- Belotti M. (Muriel)
- Benítez J. (Javier)
- Berchuck A. (Andrew)
- Berthet P. (Pascaline)
- Bertolone G. (Geoffrey)
- Bignon Y.-J. (Yves-Jean)
- Birot A.-M. (Anne-Marie)
- Bisogna M. (Maria)
- Bjorge L. (Line)
- Blomqvist C. (Carl)
- Blot W.J. (William)
- Bock G.H. (Geertruida) de
- Bogdanova N.V. (Natalia)
- Bojesen A. (Anders)
- Bojesen S.E. (Stig)
- Bolla M.K. (Manjeet K.)
- Bonadona V. (Valérie)
- Bonnani B. (Bernardo)
- Bonnet F. (Françoise)
- Borresen-Dale A.-L. (Anne-Lise)
- Bourdon V. (Violaine)
- Boutry-Kryza N. (N.)
- Bowtell D. (David)
- Brady A. (A.)
- Brauch H. (Hiltrud)
- Brennan P. (Paul)
- Brenner H. (Hermann)
- Bressac-de Paillerets B. (Brigitte)
- Bronner M. (Myriam)
- Bruinsma F. (Fiona)
- Brunet J. (Joan)
- Bubien V. (Virginie)
- Buecher B. (Bruno)
- Buhari S.A.B.S. (Shaik Ahmad Bin Syed)
- Burwinkel B. (Barbara)
- Butzow R. (Ralf)
- Buys S.S. (Saundra)
- Bézieau S. (Stéphane)
- Cai Q. (Qiuyin)
- Caldes T. (Trinidad)
- Calender A. (Alain)
- Campbell I. (Ian)
- Canniotto R. (Rikki)
- Caron O. (Olivier)
- Castera L. (Laurent)
- Chang-Claude J. (Jenny)
- Chenevix-Trench G. (Georgia)
- Chiquette J. (Jocelyne)
- Choi J.-Y. (Ji-Yeob)
- Claes K.B.M. (Kathleen B.M.)
- Colas C. (Chrystelle)
- Collonge-Rame M.-A.
- Collée J.M. (Margriet)
- Cook J. (Jackie)
- Cook L.S. (Linda S.)
- Coron F. (Fanny)
- Couch F.J. (Fergus)
- Coulet F. (Florence)
- Coupier I. (Isabelle)
- Cox A. (Angela)
- Cramer D.W. (Daniel)
- Cronenburg T.C.T.E.F. van
- Cross S.S. (Simon)
- Cybulski C. (Cezary)
- Czene K. (Kamila)
- Daly M.B. (Mary B.)
- Damette A. (Alexandre)
- Damiola F. (Francesca)
- Dansonka-Mieszkowska A. (Agnieszka)
- Darabi H. (Hatef)
- De Leeneer K. (Kim)
- DeFazio A. (Anna)
- Delgado M.K. (Melissa K.)
- Delnatte C.D. (Capucine)
- Dennis J. (Joe)
- Deurzen C.H.M. (Carolien) van
- Devilee P. (Peter)
- Doherty J.A. (Jennifer A.)
- Domchek S.M. (Susan)
- Donaldson A. (Alan)
- Dorfling C.M. (Cecilia)
- Dreyfus H. (Hélène)
- Dumont M. (Martine)
- Dunning A.M. (Alison)
- Díez O. (Orland)
- Dörk T. (Thilo)
- Eason J. (Jacqueline)
- Easton D.F. (Douglas F.)
- Edwards S.L. (Stacey)
- Ehrencrona H. (Hans)
- Ejlertsen B. (Bent)
- Elan C. (Camille)
- Ellis S.D. (Steve)
- Engel C. (Christoph)
- Evans D.G. (D. Gareth)
- Faivre L. (Laurence)
- Fasching P.A. (Peter)
- Feillel V. (Viviane)
- Feliubadaló L. (L.)
- Ferrer S.F.
- Figueroa J.D. (Jonine)
- Flesch-Janys D. (Dieter)
- Fletcher O. (Olivia)
- Flyger H. (Henrik)
- Foo C. (Claire)
- Foretova L. (Lenka)
- Fostira F. (Florentia)
- Foulkes W.D. (William)
- Fourme E. (Emmanuelle)
- Fournier J. (Joëlle)
- Fox S.B. (Stephen)
- Freedman M. (Matthew)
- French J.D. (Juliet)
- Fricker J.P. (Jean Pierre)
- Fridley B.L. (Brooke)
- Friedman E. (Eitan)
- Frost D. (Debra)
- Gambino G. (Gaetana)
- Ganz P.A. (Patricia A.)
- Garber J. (Judy)
- García-Closas M. (Montserrat)
- Gauthier-Villars M. (Marion)
- Gayther S.A. (Simon)
- Gentry-Maharaj A. (Aleksandra)
- Ghoussaini M. (Maya)
- Giles G.G. (Graham)
- Giraud S. (Sophie)
- Gladieff L. (Laurence)
- Glasspool R. (Rosalind)
- Godwin A.K. (Andrew K.)
- Goldberg M.S. (Mark)
- Goldgar D. (David)
- Golmard L. (Lisa)
- González-Neira A. (Anna)
- Goode E.L. (Ellen)
- Goodman M.T. (Marc)
- Greene M.H. (Mark H.)
- Gregory H. (Helen)
- Gronwald J. (Jacek)
- Guillaud-Bataille M. (Marine)
- Guimbaud R. (Rosine)
- Guénel P. (Pascal)
- Gómez García E.B. (Encarna)
- Haiman C.A. (Christopher A.)
- Hall P. (Per)
- Hallberg E. (Emily)
- Hamann U. (Ute)
- Hansen T.V.O. (Thomas)
- harrington P. (Patricia)
- Hartman J.M. (Joost)
- Hassan N. (Norhashimah)
- Healey S. (Sue)
- Heitz P.U.
- Henderson A. (Alex)
- Herzog J. (Josef)
- Hogervorst F.B.L. (Frans)
- Hollestelle A. (Antoinette)
- Hooning M.J. (Maartje)
- Hopper J.L. (John)
- Houdayer C. (Claude)
- Hoya M. (Miguel) de La
- Hulick P.J. (Peter)
- Huzarski T. (Tomasz)
- Høgdall C.K. (Claus)
- Høgdall E. (Estrid)
- Imyanitov E.N. (Evgeny)
- Isaacs C. (Claudine)
- Ito H. (Hidemi)
- Jacquot C. (Caroline)
- Jakubowska A. (Anna)
- Janavicius R. (Ramunas)
- Jensen A. (Allan)
- John E.M. (Esther)
- Johnson N. (Nichola)
- Kabisch M. (Maria)
- Kang D. (Daehee)
- Kapuscinski M.K. (Miroslav K.)
- Kar S. (Siddhartha)
- Karlan B.Y. (Beth Y.)
- Kennedy M.J. (John)
- Kets C.M. (Marleen)
- Khan S. (Sofia)
- Khanna K.K. (Kum Kum)
- Kiemeney L.A.L.M. (Bart)
- Kientz C. (Caroline)
- Kirk J. (Judy)
- Kjaer M. (Michael)
- Knight J.A. (Julia)
- Kolk L.E. (Lizet) van der
- Konstantopoulou I. (I.)
- Kosma V-M. (Veli-Matti)
- Kristensen V. (Vessela)
- Kuchenbaeker K. (Karoline)
- Kupryjanczyk J. (Jolanta)
- Kwong A. (Ava)
- Laitman Y. (Yael)
- Lalloo F. (Fiona)
- Lambrechts D. (Diether)
- Lange J.L. (J.) de
- Lasset C. (Christine)
- Laurent M. (Maïté)
- Lawrenson K. (Kate)
- Le Marchand L. (Loic)
- Le N.D. (Nhu D.)
- Lebrun M. (Marine)
- Lee E. (Eunjung)
- Lee J.M. (Janet M.)
- Leeuwen F.E. (Flora) van
- Leroux D. (Dominique)
- Lester K.J. (Kathryn)
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- Li J. (Jingmei)
- Li Q. (Qiyuan)
- Lindblom A. (Annika)
- Lindeman G.J. (Geoffrey)
- Lizard S. (Sarab)
- Long J. (Jirong)
- Longy M. (Michel)
- Lophatananon A. (Artitaya)
- Loud J.T. (Jennifer)
- Lu K.H. (Karen)
- Lubinski J. (Jan)
- Léone M. (Mélanie)
- Mannermaa A. (Arto)
- Manoukian S. (Siranoush)
- Margolin S. (Sara)
- Mari V. (Véronique)
- Marme F. (Frederick)
- Massuger L.F. (Leon)
- Matsuo K. (Keitaro)
- Mazoyer S. (Sylvie)
- McCann E. (Emma)
- McCue K. (Karen)
- McGuffog L. (Lesley)
- McLean C.A. (Catriona Ann)
- McNeish I. (Iain)
- Mebirouk N. (Noura)
- Meijers-Heijboer E.J. (Hanne)
- Meindl A. (Alfons)
- Menon U. (Usha)
- Mensenkamp A.R. (Arjen R.)
- Michailidou K. (Kyriaki)
- Miedzybrodzka Z. (Zosia)
- Milne R.L. (Roger)
- Moncoutier V. (Virginie)
- Montagna M. (Marco)
- Monteiro A.N.A. (Alvaro N.)
- Morrison P.J. (Patrick)
- Mortemousque I. (Isabelle)
- Mourits M.J. (Marjan)
- Moysich K.B. (Kirsten)
- Muir K.R. (K.)
- Muller D.W. (Danièle)
- Mulligan A.-M. (Anna-Marie)
- Murray A. (Alexandra)
- Nathanson K.L. (Katherine)
- Ness R.B. (Roberta)
- Neuhausen S.L. (Susan)
- Nevanlinna H. (Heli)
- Noguchi T. (Tetsuro)
- Nord S. (Silje)
- Nussbaum R.L. (Robert L.)
- O'Malley D.M. (David M.)
- Obdeijn A.I.M. (Inge-Marie)
- Odunsi K. (Kunle)
- Offit K. (Kenneth)
- Olah E.
- Olopade O.I. (Olufunmilayo I.)
- Olson J.E. (Janet)
- Olswold C. (Curtis)
- Oosterwijk J.C. (Jan)
- Orlow I. (Irene)
- Orr N. (Nick)
- Os T.A.M. (Theo) van
- Osorio A. (Ana)
- Overbeek L.I.H. (Lucy)
- Park S.K. (Sue Kyung)
- Pauw A. (Antoine) de
- Pearce C.L. (Celeste)
- Pejovic T. (Tanja)
- Peterlongo P. (Paolo)
- Peyrat J.-P.
- Peysselon M. (Magalie)
- Pfeiler G. (Georg)
- Pharoah P.D.P. (Paul)
- Phelan C. (Catherine)
- Pol C. (Carmen) van der
- Poole E.M. (Elizabeth)
- Porteous M.E. (Mary)
- Price M. (Melanie)
- Prieur F. (Fabienne)
- Pujol P. (Pascal)
- Pykäs K. (Katri)
- Radice P. (Paolo)
- Ramus S.J. (Susan)
- Rantala J. (Johanna)
- Rashid M.U. (Muhammad)
- Rebischung C. (Christine)
- Remenieras A. (Audrey)
- Rennert G. (Gad)
- Rensburg E.J. (Elizabeth) van
- Rhenius V. (Valerie)
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- Risch H. (Harvey)
- Rodriguez G.C. (Gustavo)
- Rogers M.T. (Mark)
- Rookus M.A. (Matti)
- Rossing M.A. (Mary Anne)
- Rouleau E. (Etienne)
- Rudolph A. (Anja)
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- Sangrajrang S. (Suleeporn)
- Saule C. (Claire)
- Sawyer E.J. (Elinor J.)
- Schildkraut J.M. (Joellen)
- Schmidt M.K. (Marjanka)
- Schmidt M.K. (Marjanka)
- Schmutzler R.K. (Rita)
- Sellers T.A. (Thomas A.)
- Sevenet N. (Nicolas)
- Seynaeve C.
- Seynaeve C.M. (Caroline)
- Shah M. (Mitul)
- Shen C.-Y. (Chen-Yang)
- Shu X.-O. (Xiao-Ou)
- Side L. (Lucy)
- Sieh W. (Weiva)
- Siesling S.
- Simard J. (Jacques)
- Singer C.F. (Christian)
- Sinilnikova O. (Olga)
- Slager S. (Susan)
- Snape K. (Katie)
- Sobol H. (Hagay)
- Sokolowska J. (Johanna)
- Song H. (Honglin)
- Soubrier F.
- Soucy P. (Penny)
- Southey M.C. (Melissa)
- Stenmark-Askmalm M. (Marie)
- Stoppa-Lyonnet D. (Dominique)
- Sutter C. (Christian)
- Swerdlow A.J. (Anthony )
- Tchatchou S. (Sandrine)
- Teixeira P.J.
- Teo S.-H. (Soo-Hwang)
- Terry K.L. (Kathryn)
- Terry M.B. (Mary Beth)
- Thomassen M. (Mads)
- Tibiletti M.G. (Maria Grazia)
- Tihomirova L. (Laima)
- Tognazzo S. (Silvia)
- Toland A.E. (Amanda)
- Tollenaar R.A.E.M. (Rob)
- Tomlinson I.P. (Ian)
- Torres D. (Diana)
- Toulas C. (Christine)
- Truong T. (Thérèse)
- Tseng C.-C. (Chiu-Chen)
- Tung N. (Nadine)
- Tworoger S.S. (Shelley S.)
- Tyrer J.P. (Jonathan)
- Uhrhammer N. (Nancy)
- Vachon C. (Celine)
- Van Den Ouweland A.M.W. (Ans M.W.)
- Van Doorn H.C. (Helena C.)
- Vanderstichele A. (Adriaan)
- Vasen H. (Hans)
- Vaur D. (Dominique)
- Veer L.J. (Laura) van 't
- Vergote I. (Ignace)
- Verloop J.
- Verny-Pierre C. (Carole)
- Vijai J. (Joseph)
- Vénat-Bouvet L. (Laurence)
- Waisfisz Q. (Quinten)
- Walker L.J. (Lisa)
- Wang Q. (Qin)
- Wang-Gohrke S. (Shan)
- Warcoin M. (Mathilde)
- Webb P. (Penny)
- Weitzel J.N. (Jeffrey)
- Wentzensen N. (N.)
- Whittemore A.S. (Alice)
- Wijnands R.
- Wildiers H. (Hans)
- Winqvist R. (Robert)
- Wu A.H. (Anna)
- Yannoukakos D. (Drakoulis)
- Yoon S.-Y. (Sook-Yee)
- Yu J-C. (Jyh-Cherng)
- Zheng W. (Wei)
- Zheng Y. (Ying)
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 07/09/2016
- Field of study
A locus at 19p13 is associated with breast cancer (BC) and ovarian cancer (OC) risk. Here we analyse 438 SNPs in this region in 46,451 BC and 15,438 OC cases, 15,252 BRCA1 mutation carriers and 73,444 controls and identify 13 candidate causal SNPs associated with serous OC (P=9.2 × 10-20), ER-negative BC (P=1.1 × 10-13), BRCA1-associated BC (P=7.7 × 10-16) and triple negative BC (P-diff=2 × 10-5). Genotype-gene expression associations are identified for candidate target genes ANKLE1 (P=2 × 10-3) and ABHD8 (P<2 × 10-3). Chromosome conformation capture identifies interactions between four candidate SNPs and ABHD8, and luciferase assays indicate six risk alleles increased transactivation of the ADHD8 promoter. Targeted deletion of a region containing risk SNP rs56069439 in a putative enhancer induces ANKLE1 downregulation; and mRNA stability assays indicate functional effects for an ANKLE1 3′-UTR SNP. Altogether, these data suggest that multiple SNPs at 19p13 regulate ABHD8 and perhaps ANKLE1 expression, and indicate common mechanisms underlying breast and ovarian cancer risk
Genome-Wide Association Study in BRCA1 Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk
- Author
- Aalfs C.M. (Cora)
- Adenis C. (Claude)
- Adlard J.W. (Julian)
- Agata S. (Simona)
- Agnarsson B.A. (Bjarni)
- Aittomäki K. (Kristiina)
- Andersen M.K. (Mette)
- Andrulis I.L. (Irene)
- Angelakos M. (Maggie)
- Antoniou A.C. (Antonis)
- Ardern-Jones A. (Audrey)
- Ardnor C.E. (Christina Edwinsdotter)
- Arnold N. (Norbert)
- Arun B.K. (Banu)
- Arver B. (Brita Wasteson)
- Asperen C.J. (Christi) van
- Attard V. (Virginia)
- Ausems M.G.E.M. (Margreet)
- Bacot F. (Francois)
- Bae-Jump V.L. (Victoria L.)
- Balmana J. (Judith)
- Bancroft E.K. (Elizabeth)
- Bardsley C. (Cathryn)
- Barjhoux L. (Laure)
- Barkardottir R.B. (Rosa)
- Barouk-Simonet E. (Emmanuelle)
- Barrowdale D. (Daniel)
- Barton D.E. (David)
- Barwell J. (Julian)
- Beattie M.S. (Mary)
- Belotti M. (Muriel)
- Benítez J. (Javier)
- Berlin C. (Cheryl)
- Berthet P. (Pascaline)
- Bignon Y.-J. (Yves-Jean)
- Bignon Y.-J. (Yves-Jean)
- Blanco I. (Ignacio)
- Blank S.V. (Stephanie)
- Blok M.J. (Marinus)
- Bock G.H. (Geertruida) de
- Bonadona V. (Valérie)
- Bonnani B. (Bernardo)
- Bonnet F. (Françoise)
- Borg Å. (Åke)
- Bourdon V. (Violaine)
- Bradshaw N. (Nicola)
- Brady A.F. (Angela)
- Bressac-de Paillerets B. (Brigitte)
- Brewer C. (C.)
- Brewer C. (Carole)
- Brice G. (Glen)
- Bronner M. (Myriam)
- Brunet J. (Joan)
- Bubien V. (Virginie)
- Buecher B. (Bruno)
- Bustinza G.B.
- Buys S.S. (Saundra)
- Caldes T. (Trinidad)
- Calender A. (Alain)
- Caligo M.A. (Maria)
- Campbell I. (Ian)
- Caron O. (Olivier)
- Castera L. (Laurent)
- Castro E. (Elena)
- Chan S. (Salina)
- Chenevix-Trench G. (Georgia)
- Chiquette J. (Jocelyne)
- Chung W.K. (Wendy)
- Claber O. (Oonagh)
- Claes K. (Kathleen)
- Cohn D.E. (David)
- Colas C. (Chrystelle)
- Cole T.J. (Trevor)
- Collier R. (Rebecca)
- Collée J.M. (Margriet)
- Cook J. (Jackie)
- Coron F. (Fanny)
- Couch F.J. (Fergus)
- Coulet F. (Florence)
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- Crawford G. (Gabe)
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- Cunningham J. (Jane)
- Daly M.B. (Mary)
- Damiola F. (Francesca)
- Damiola F. (Francesca)
- Davidson R. (Rosemarie)
- Deissler H. (Helmut)
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- Demange L. (Liliane)
- Dennis J. (Joe)
- Deurzen C.H.M. (Carolien) van
- Devilee P. (Peter)
- Devilee P. (Peter)
- Dicks E. (Ed)
- Diez O. (Orland)
- Ding Y.C. (Yuan)
- Dite G.S. (Gillian)
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- Donaldson A. (Alan)
- Dorfling C.M. (Cecelia)
- Dorkins H. (Huw)
- Douglas F. (Fiona)
- Douglas F. (Fiona)
- Dreyfus H. (Hélène)
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- Duncan A. (Alexis)
- Dunning A.M. (Alison)
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- Durell S. (Sarah)
- Durán M. (Mercedes)
- Eason J. (Jacqueline)
- Easton D.F. (Douglas)
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- Eddy C. (Charlotte)
- Eeles R. (Rosalind)
- Ehrencrona H. (Hans)
- Einbeigi Z. (Zakaria)
- Eisinger F. (François)
- Ejlertsen B. (Bent)
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- Ellis S. (Steve)
- Ellis S.D. (Steve)
- Emanuelsson M. (Monica)
- Engel C. (Christoph)
- Engert S. (Stefanie)
- Evans D.G. (Gareth)
- Ewart-Toland A. (Amanda)
- Faivre L. (Laurence)
- Feillel V. (Viviane)
- Ferrer S.F.
- Fineberg E. (Elena)
- Fineberg E. (Elena)
- Fink-Retter A. (Anneliese)
- Foretova L. (Lenka)
- Fournier J. (Joëlle)
- Fredericksen Z. (Zachary)
- Frenay M. (Marc)
- Fricker J.P. (Jean Pierre)
- Friebel M.O.W. (Mark )
- Friedlander M. (Michael)
- Friedman E. (Eitan)
- Frost D. (Debra)
- Gadzicki D. (Dorothea)
- Ganz P.A. (Patricia)
- Garber J.
- Gaudet M.M. (Mia)
- Gauthier-Villars M. (Marion)
- Gehrig P.A. (Paola A.)
- Gerdes A-M. (Anne-Marie)
- Gibson S. (Sarah)
- Gille J.J. (Johan)
- Giraud S. (Sophie)
- Gladieff L. (Laurence)
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- Godwin A.K. (Andrew)
- Goff S. (Sheila)
- Goldgar D. (David)
- Gomez Garcia E.B. (Encarna)
- Goodman S. (Selina)
- Greene M.H. (Mark)
- Gregory H. (Helen)
- Gronwald J. (Jacek)
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- hardouin A. (Agnès)
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- Wachenfeldt A. (Anna) von
- Waisfisz Q. (Quinten)
- Walker L.J. (Lisa)
- Walsh C.S. (Christine)
- Wang C. (Chen)
- Wang X. (Xianshu)
- Wapenschmidt B. (Barbara)
- Watt C. (Catherine)
- Weaver J. (JoEllen)
- Weber B.H.F. (Bernhard)
- Weitzel J.N. (Jeffrey)
- Wiggins J. (Jennifer)
- Wijnen J.T. (Juul)
- Wijnen J.T. (Juul)
- Winchester L. (Lizzie)
- Yannoukakos D. (Drakoulis)
- Złowocka-Perłowska E. (Elzbieta)
- Öfverholm A. (Anna)
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 15/04/2013
- Field of study
BRCA1-associated breast and ovarian cancer risks can be modified by common genetic variants. To identify further cancer risk-modifying loci, we performed a multi-stage GWAS of 11,705 BRCA1 carriers (of whom 5,920 were diagnosed with breast and 1,839 were diagnosed with ovarian cancer), with a further replication in an additional sample of 2,646 BRCA1 carriers. We identified a novel breast cancer risk modifier locus at 1q32 for BRCA1 carriers (rs2290854, P = 2.7×10-8, HR = 1.14, 95% CI: 1.09-1.20). In addition, we identified two novel ovarian cancer risk modifier loci: 17q21.31 (rs17631303, P = 1.4×10-8, HR = 1.27, 95% CI: 1.17-1.38) and 4q32.3 (rs4691139, P = 3.4×10-8, HR = 1.20, 95% CI: 1.17-1.38). The 4q32.3 locus was not associated with ovarian cancer risk in the general population or BRCA2 carriers, suggesting a BRCA1-specific associat
A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers
- Author
- Aalfs C.M. (Cora)
- Adamo P. (Pio) d'
- Adank M.A. (Muriel)
- Adenis C. (Claude)
- Adlard J.W. (Julian)
- Agata S. (Simona)
- Ahearn T. (Thomas)
- Aittomäki K. (Kristiina)
- Andrieu N. (Nadine)
- Andrulis I.L. (Irene L.)
- Anton-Culver H. (Hoda)
- Antoniou A.C. (Antonis C.)
- Arndt V. (Volker)
- Arnold N. (Norbert)
- Aronson K.J. (Kristan J.)
- Arun B.K. (Banu)
- Augustinsson A. (Annelie)
- Ausems M.G.E.M. (Margreet)
- Azzollini J.
- Barjhoux L. (Laure)
- Barnes D. (Daniel)
- Barouk-Simonet E. (Emmanuelle)
- Barrowdale D. (Daniel)
- Barwell J. (Julian)
- Baurand A. (Amandine)
- Baxter R. (Robert)
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- Becher H. (Heko)
- Beesley J. (Jonathan)
- Belotti M. (Muriel)
- Bermisheva M. (Marina)
- Bernstein L. (Leslie)
- Berthet P. (Pascaline)
- Bertolone G. (Geoffrey)
- Bertrand O. (Ophélie)
- Białkowska K. (Katarzyna)
- Bignon Y.-J. (Yves-Jean)
- Birot A.-M. (Anne-Marie)
- Blok M.J. (Marinus J.)
- Blomqvist C. (Carl)
- Bock G.H. (Geertruida) de
- Bojesen S.E. (Stig)
- Bolla M.K. (Manjeet K.)
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- Soubrier F. (Florent)
- Soucy P. (Penny)
- Southey M.C. (Melissa C.)
- Southey M.C. (Melissa)
- Spinelli J.J. (John J.)
- Spurdle A. (Amanda)
- Steinsnyder Z. (Zoe)
- Stone J. (Jennifer)
- Stoppa-Lyonnet D. (Dominique)
- Swerdlow A.J. (Anthony )
- Tamimi R. (Rulla)
- Tapper W.J. (William J.)
- Tassell M. (Margaret)
- Taylor J.A. (Jack A.)
- Terry M.B. (Mary Beth)
- Teulé A. (Alex)
- Thomassen M. (Mads)
- Thull D.L. (Darcy L.)
- Tischkowitz M. (Marc)
- Toland A.E. (Amanda)
- Torres D. (Diana)
- Toulas C. (Christine)
- Trainer A.H. (Alison H.)
- Truong T. (Thérèse)
- Tung N. (Nadine)
- Tyrer J.P. (Jonathan P.)
- Uhrhammer N. (Nancy)
- Vachon C. (Celine)
- van Asperen C.J. (Christi J.)
- van der Luijt R.B. (Rob B.)
- Vaur D. (Dominique)
- Vega A. (Ana)
- Verny-Pierre C. (Carole)
- Vénat-Bouvet L. (Laurence)
- Walker L. (Lisa)
- Wang Q. (Qin)
- Wappenschmidt B. (Barbara)
- Warcoin M. (Mathilde)
- Webb P. (Penny)
- Weinberg C.R. (Clarice R.)
- Weitzel J.N. (Jeffrey)
- Wendt C. (Camilla)
- Wijnands R. (R.)
- Wijnen J.T. (Juul)
- Wolk K. (Kerstin)
- Yadav S. (Siddhartha)
- Yang X.R. (Xiaohong R.)
- Yannoukakos D. (Drakoulis)
- Yip D. (Desmond)
- Zheng W. (Wei)
- Ziogas A. (Argyrios)
- Zorn K.K. (Kristin K.)
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 17/02/2021
- Field of study
Breast cancer (BC) risk for BRCA1 and BRCA2 mutation carriers varies by genetic and familial factors. About 50 common variants have been shown to modify BC risk for mutation carriers. All but three, were identified in general population studies. Other mutation carrier-specific susceptibility variants may exist but studies of mutation carriers have so far been underpowered. We conduct a novel case-only genome-wide association study comparing genotype frequencies between 60,212 general population BC cases and 13,007 cases with BRCA1 or BRCA2 mutations. We identify robust novel associations for 2 variants with BC for BRCA1 and 3 for BRCA2 mutation carriers, P < 10−8, at 5 loci, which are not associated with risk in the general population. They include rs60882887 at 11p11.2 where MADD, SP11 and EIF1, genes previously implicated in BC biology, are predicted as potential targets. These findings will contribute towards customising BC polygenic risk scores for BRCA1 and BRCA2 mutation carriers
The Effect of Stimulus Repetition Rate on the Auditory Brainstem Response in Tumor and Nontumor Patients
- Publication venue
- 'American Speech Language Hearing Association'
- Publication date
- Field of study
The Effect of D-Methionine on Cochlear Oxidative State with and without Cisplatin Administration: Mechanisms of Otoprotection
- Publication venue
- 'Georg Thieme Verlag KG'
- Publication date
- Field of study
Antioxidant Enzyme Levels Inversely Covary with Hearing Loss After Amikacin Treatment
- Publication venue
- 'Georg Thieme Verlag KG'
- Publication date
- Field of study
Glutathione Ester But Not Glutathione Protects Against Cisplatin-Induced Ototoxicity in a Rat Model
- Publication venue
- 'Georg Thieme Verlag KG'
- Publication date
- Field of study
Platinum-Induced Ototoxicity in Children: A Consensus Review on Mechanisms, Predisposition, and Protection, Including a New International Society of Pediatric Oncology Boston Ototoxicity Scale
- Author
- Blakley BW
- Brian J. Fligor
- Brian W. Blakley
- Brock PR
- Campbell K
- Cloven NG
- David R. Freyer
- Doolittle ND
- Edward A. Neuwelt
- Kathleen C.M. Campbell
- Kaukab Rajput
- Kay W. Chang
- Kopke RD
- Kristin R. Knight
- Laurell G
- Lesaffre E
- Michael Sullivan
- Muldoon LL
- Neuwelt EA
- Neuwelt EA
- Park MS
- Penelope R. Brock
- Peter S. Steyger
- Rybak LP
- Shahrad R. Rassekh
- Publication venue
- 'American Society of Clinical Oncology (ASCO)'
- Publication date
- Field of study
Audiologic Monitoring for Ototoxicity
- Author
- Anderson
- Assael
- Berlin
- Brown
- Brummett
- Brummett
- Carhart
- Chang
- Collet
- Dobie
- Dreschler
- Durrant
- Fausti
- Fausti
- Fausti
- Fausti
- Fausti
- Feghali
- Finitzo-Hieber
- Fletcher
- Frank
- Frank
- Jacobson
- John Durrant
- Kamalakar
- Kathleen C.M. Campbell
- Kemp
- Kemp
- Koegel
- Kujansuu
- Lemer
- Long
- Lonsbury-Martin
- Lonsbury-Martin
- Martin
- Martin
- Matz
- McFadden
- Melamed
- Meyerhoff
- Northern
- Northern
- Northern
- Norton
- Osterhammel
- Probst
- Quick
- Rappaport
- Reddel
- Rybak
- Rybak
- Simpson
- Stelmachowicz
- Stypulkowski
- Tange
- Thompson
- Thornton
- Turner
- Valente
- van der Hulst
- Ventry
- Whitehead
- Wier
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study