Synthesis and antihyperlipidemic activity of some novel 4-substituted-2-substitutedmethyltriazino[6,1-b]quinazolin-10-ones and 2,4-disubstituted-6,7-dimethoxy quinazoline

The synthesis and antihyperlipidemic activity of some novel 4-substituted-2-substitutedmethyltriazino[6,1-b]quinazolin-10-ones and 2,4-disubstituted-6,7-dimethoxy quinazoline derivatives are described. Among the series 4-chloro-2-acetoxymethyl-3H,11H-[1,2,4]triazino[6,1-b] quinazoline-4,10-dione 5d has shown better activity in case of % reduction in serum cholesterol level while 4-chloro-10-oxo-10H-[1,2,4]triazino[6,1-b]quinazolin-2-yl benzoate 5f in reducing % serum triglyceride level than that of the standard. 4-Hydroxyquinazolin-2-yl nicotinate 6g has significantly increased serum HDL level. Among the series compound 6g has shown promising results over all in lipid profile. These molecules indeed have the potential to be developed as an antihyperlipaemic molecule