Evaluating the Possibilities of Sports Activities for the Inhabitants of Frýdek-Místek

Tato bakalářská práce je zaměřená na hodnocení spokojenosti obyvatel Frýdeku-Místku se sportovním vyžitím. Jako výzkumné metody k zjištění této skutečnosti byly použity SWOT analýza, rozhovor a dotazník. Z výsledků zjištěných výzkumnými metodami lze říci, že i přes menší nedostatky jsou obyvatelé města Frýdku-Místku z větší části se sportovním vyžitím ve městě spokojeni.This bachelor thesis is focused on the evaluation of satisfaction of the inhabitants of Frýdek-Místek with sporting activities. As research methods to determine this fact, the SWOT analysis, the interview and the questionnaire were used. From the results found by the research methods it can be said that despite the minor deficiencies, the inhabitants of the town Frýdek-Místek are mostly satisfied with the sporting enjoyment.115 - Katedra managementuvýborn

Debt Relief of Married Couples as One of the Ways of Solving Bankruptcy

Tato diplomová práce se zabývá problematikou oddlužení manželů. První část je věnována základní charakteristice a vymezení insolvenčního řízení, což je popsáno v první kapitole. Celkový proces oddlužení manželů v insolvenčním řízení je popsán v další kapitole. Druhá část této diplomové práce je zaměřena na analýzu a vyhodnocení případových studii oddlužení manželů z praxe.This diploma thesis deals with the issue of debt relief of married couples. The first part is devoted to the basic characteristics and definitions of insolvency proceedings, which is described in the first chapter. The whole process of debt relief for married couples in insolvency proceedings is described in the next chapter. The second part of this diploma thesis is focused on the analysis and evaluation of case studies of married couples' debt reliefs from practice.117 - Katedra účetnictví a danívelmi dobř

TROP2 Represents a Negative Prognostic Factor in Colorectal Adenocarcinoma and Its Expression Is Associated with Features of Epithelial–Mesenchymal Transition and Invasiveness

Trophoblastic cell surface antigen 2 (TROP2) is a membrane glycoprotein overexpressed in many solid tumors with a poor prognosis, including intestinal neoplasms. In our study, we show that TROP2 is expressed in preneoplastic lesions, and its expression is maintained in most colorectal cancers (CRC). High TROP2 positivity correlated with lymph node metastases and poor tumor differentiation and was a negative prognostic factor. To investigate the role of TROP2 in intestinal tumors, we analyzed two mouse models with conditional disruption of the adenomatous polyposis coli (Apc) tumor-suppressor gene, human adenocarcinoma samples, patient-derived organoids, and TROP2-deficient tumor cells. We found that Trop2 is produced early after Apc inactivation and its expression is associated with the transcription of genes involved in epithelial–mesenchymal transition, the regulation of migration, invasiveness, and extracellular matrix remodeling. A functionally similar group of genes was also enriched in TROP2-positive cells from human CRC samples. To decipher the driving mechanism of TROP2 expression, we analyzed its promoter. In human cells, this promoter was activated by β-catenin and additionally by the Yes1-associated transcriptional regulator (YAP). The regulation of TROP2 expression by active YAP was verified by YAP knockdown in CRC cells. Our results suggest a possible link between aberrantly activated Wnt/β-catenin signaling, YAP, and TROP2 expression