Arsenic trioxide downregulates cancer procoagulant activity in MCF-7 and WM-115 cell lines in vitro

© 2015 Termedia Sp. z o. o. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.THE AIM OF THE STUDY: To analyze human breast cancer cell line MCF-7 and human malignant melanoma cell line WM-115 in order to characterize the cellular expression of CP and to evaluate whether ATO may affect this activity, as well as the viability of the cells.MATERIAL AND METHODS: The inhibitory effect of arsenic trioxide on the proliferation of MCF-7 and WM-115 cells were measured with MTT test. The activity of cancer procoagulant after ATO exposure was determined by a specific three-stage chromogenic assay.RESULTS: ATO decreased the CP activity in a dose- and time-dependent manner in MCF-7 cells with no effect on cell proliferation at the same time. However, it affected the CP activity of WM-115 cells in a different way. Reduction in CP activity was followed by an increase after 48 h incubation. The cells viability results showed dose-and time-correlated response within high arsenic concentrations.CONCLUSIONS: Arsenic trioxide downregulates the CP expression in human breast cancer and melanoma cells.Peer reviewedFinal Published versio

Russia's Afghan problem: The Russian Federation and the Afghanistan problem since 2001. OSW Study 38/2011

Russia is facing a difficult choice regarding its further policy towards the Afghan problem. It seems that Moscow has no coherent or consistent strategy. It is likely that the Russian ruling elite, like expert circles, is divided on this issue. In practice, the Russian authorities now seem to be simultaneously implementing elements of various strategies, thus trying to leave themselves the widest possible room for manoeuvre

Influence the quality of the interface of online stores on their memorability

The article describes influence the quality of the interface of online stores on their memorability on selected examples. Nielsen heuristics, LUT’s list and mamorability experiment were used in interface quality assesment