A COMPARISON OF 2-POINT, 3-POINT AND DELETION MAPPING IN THE C-CISTRON OF RHIZOBIOPHAGE-16-3, WITH AN EXPLANATION FOR THE RECOMBINATION PATTERN

A general tendency for additivity prevailed in recombination frequencies for two-point fine-structure mapping of 14 mutants in the C cistron of Rhizobium meliloti phage 16-3, with little evidence of any marker effect. Intracistronic three-point mapping indicated that double crossovers are rare. Deletion mapping indicated that the two- and three-point mapping data gave the correct order of the mutations. A high frequency (5 to 8%) of c/c+ heterozygotic phage progenies was observed in standard crosses. This pattern implies formation of a relatively long region of heterozygosity. Together with the results of the three-point tests, it suggests certain properties of the branch migration and resolution steps envisioned in current mechanisms of recombination

Forest plot analysis of mortality rate using random-effects model in septic patients with hypothermia (body temperature up to 36.0°C; <i>n</i> = 890).

<p>Forest plot analysis of mortality rate using random-effects model in septic patients with hypothermia (body temperature up to 36.0°C; <i>n</i> = 890).</p

Forest plot analysis of mortality rate using random-effects model in septic patients with fever (body temperature above 38.0°C; <i>n</i> = 6,040).

<p>Forest plot analysis of mortality rate using random-effects model in septic patients with fever (body temperature above 38.0°C; <i>n</i> = 6,040).</p

Flowchart of study selection and inclusion.

<p>Flowchart of study selection and inclusion.</p

Meta-regression analysis of the association between body temperature and mortality ratio in septic patients (<i>n</i> = 10, 834).

<p>Meta-regression analysis of the association between body temperature and mortality ratio in septic patients (<i>n</i> = 10, 834).</p

Forest plot analysis of mortality rate using random-effects model in septic patients with normothermia (body temperature between 36.1 and 38.0°C; <i>n</i> = 3,904).

<p>Forest plot analysis of mortality rate using random-effects model in septic patients with normothermia (body temperature between 36.1 and 38.0°C; <i>n</i> = 3,904).</p