Strict Solution Method for Linear Programming Problem with Ellipsoidal Distributions under Fuzziness

This paper considers a linear programming problem with ellipsoidal distributions including fuzziness. Since this problem is not well-defined due to randomness and fuzziness, it is hard to solve it directly. Therefore, introducing chance constraints, fuzzy goals and possibility measures, the proposed model is transformed into the deterministic equivalent problems. Furthermore, since it is difficult to solve the main problem analytically and efficiently due to nonlinear programming, the solution method is constructed introducing an appropriate parameter and performing the equivalent transformations

Risk-Controlled Multiobjective Portfolio Selection Problem Using a Principle of Compromise

This paper proposes a multiobjective portfolio selection problem with most probable random distribution derived from current market data and other random distributions of boom and recession under the risk-controlled parameters determined by an investor. The current market data and information include not only historical data but also interpretations of economists’ oral and linguistic information, and hence, the boom and recession are often caused by these nonnumeric data. Therefore, investors need to consider several situations from most probable condition to boom and recession and to avoid the risk less than the target return in each situation. Furthermore, it is generally difficult to set random distributions of these cases exactly. Therefore, a robust-based approach for portfolio selection problems using the only mean values and variances of securities is proposed as a multiobjective programming problem. In addition, an exact algorithm is developed to obtain an explicit optimal portfolio using a principle of compromise

Interfractional target changes in brain metastases during 13-fraction stereotactic radiotherapy

[Background] The risk for radiation necrosis is lower in fractionated stereotactic radiotherapy (SRT) than in conventional radiotherapy, and 13-fraction SRT is our method of choice for the treatment of brain metastases ≥ around 2 cm or patients who are expected to have a good prognosis. As 13-fraction SRT lasts for at least 17 days, adaptive radiotherapy based on contrast-enhanced mid-treatment magnetic resonance imaging (MRI) is often necessary for patients undergoing 13-fraction SRT. In this study, we retrospectively analyzed interfractional target changes in patients with brain metastases treated with 13-fraction SRT. [Methods] Our analyses included data from 23 patients and 27 metastatic brain lesions treated with 13-fraction SRT with dynamic conformal arc therapy. The peripheral dose prescribed to the planning target volume (PTV) was 39–44.2 Gy in 13-fractions. The gross tumor volume (GTV) of the initial SRT plan (initial GTV), initial PTV, and modified GTV based on the mid-treatment MRI scan (mid-treatment GTV) were assessed. [Results] The median initial GTV was 3.8 cm3 and the median time from SRT initiation to the mid-treatment MRI scan was 6 days. Compared to the initial GTV, the mid-treatment GTV increased by more than 20% in five lesions and decreased by more than 20% in five lesions. Interfractional GTV volume changes of more than 20% were not significantly associated with primary disease or the presence of cystic components/necrosis. The mid-treatment GTV did not overlap perfectly with the initial PTV in more than half of the lesions. [Conclusions] Compared to the initial GTV, the mid-treatment GTV changed by more than 20% in almost one-third of lesions treated with 13-fraction SRT. As SRT usually generates a steep dose gradient as well as increasing the maximum dose of PTV compared to conventional radiotherapy, assessment of the volume and locational target changes and adaptive radiotherapy should be considered as the number of fractions increases

Effects of nicorandil, a potassium channel opener, on idiopathic ventricular tachycardia

AbstractObjectives. We assessed the effects of the adenosine triphosphate (ATP)–sensitive potassium channel opener, nicorandil, on ATP- and verapamil-responsive ventricular tachycardias (VTs).Background. Adenosine- or ATP-sensitive VTs are thought to be due to a nonreentrant mechanism, presumably delayed afterdepolarization. We suggest that this potassium channel opener may suppress ATP- and verapamil-sensitive VTs.Methods. The subjects included 13 patients with idiopathic VTs, 7 of whom had sustained VT and 6 of whom had nonsustained VT. We evaluated the effects of ATP, nicorandil and verapamil on VTs.Results. Sustained VT: Verapamil had preventive effects on seven VTs. Four VTs were terminated by ATP, and of these, nicorandil terminated two and prevented exercise-induced VT in the two others. Three ATP-insensitive VTs, which were determined to be due to a reentry by an electrophysiologic study, were not terminated by nicorandil. Nonsustained VT: All six VTs were inhibited by ATP, and five of these were suppressed by nicorandil. Verapamil inhibited four of the five VTs. QT intervals and the corrected QT intervals were significantly shortened by nicorandil.Conclusions. Nicorandil suppresses ATP- and verapamil-responsive VTs. One of the mechanisms of suppression by nicorandil might be related to a reduction of calcium in the myocardium, because it reduces the action potential duration

The 2015 Gorkha Nepal Earthquake: Insights from Earthquake Damage Survey

The 2015 Gorkha Nepal earthquake caused tremendous damage and loss. To gain valuable lessons from this tragic event, an earthquake damage investigation team was dispatched to Nepal from 1 May 2015 to 7 May 2015. A unique aspect of the earthquake damage investigation is that first-hand earthquake damage data were obtained 6–11 days after the mainshock. To gain deeper understanding of the observed earthquake damage in Nepal, the paper reviews the seismotectonic setting and regional seismicity in Nepal and analyzes available aftershock data and ground motion data. The earthquake damage observations indicate that the majority of the damaged buildings were stone/brick masonry structures with no seismic detailing, whereas the most of RC buildings were undamaged. This indicates that adequate structural design is the key to reduce the earthquake risk in Nepal. To share the gathered damage data widely, the collected damage data (geo-tagged photos and observation comments) are organized using Google Earth and the kmz file is made publicly available