9 research outputs found

    Multidrug resistance of Staphylococcus aureus strains isolated from medical centers of Batna (north-east Algeria)

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    The emergence of resistant strains of Staphylococcus aureus is a major public health problem mainly in hospitals around the world and in Algeria in particular. This work aims to assess the resistance of Staphylococcus aureus in the University Hospital Center of Batna and the Hematology Unit of the Anti-Cancer Center using conventional standardized methods during a study period of four months. A total of  70 strains of S. aureus were isolated and their antibiotic susceptibility study showed significant resistance to β-lactam especially to penicillin (95.71%) and  61.43% to tobramycin. The methicillin-resistant strains (MRSA) formed 30%. Resistant strains to macrolide-lincosamide streptogramin B (MLSB) and aminoglycosides (KTG) classes presented 17.14% and 21.43% respectively. These results require a control plan by compliance with the hygiene conditions and the organization of the prescription of antibiotics and other molecular and epidemiological studies. DOI: http://dx.doi.org/10.5281/zenodo.799635

    Multidrug resistance of Staphylococcus aureus strains isolated from medical centers of Batna (north-east Algeria)

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    The emergence of resistant strains of Staphylococcus aureus is a major public health problem mainly in hospitals around the world and in Algeria in particular. This work aims to assess the resistance of Staphylococcus aureus in the University Hospital Center of Batna and the Hematology Unit of the Anti-Cancer Center using conventional standardized methods during a study period of four months. A total of  70 strains of S. aureus were isolated and their antibiotic susceptibility study showed significant resistance to β-lactam especially to penicillin (95.71%) and  61.43% to tobramycin. The methicillin-resistant strains (MRSA) formed 30%. Resistant strains to macrolide-lincosamide streptogramin B (MLSB) and aminoglycosides (KTG) classes presented 17.14% and 21.43% respectively. These results require a control plan by compliance with the hygiene conditions and the organization of the prescription of antibiotics and other molecular and epidemiological studies. DOI: http://dx.doi.org/10.5281/zenodo.799635

    Towards a better control of the infectious risks associated with health care activities

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    Abstract The infection associated with health care is a major cause of morbidity and mortality in health establishment. For a dialyzed renal failure, it would be responsible of about 15 % of the deaths. To answer this issue, health establishments use a classical approach, which rests essentially on risk management practices, which enters within the scope of a global analysis of risk management. These practices are built on the anticipation principle; they are based on the identification and the control of the possible risks, of which it is practically impossible to guarantee the exhaustiveness of the risky situations, so it is not possible to leave these anticipation practices at the present time. This is why, for better a control of the infectious risks associated with health care, it is necessary to consolidate more and more this preventive approach and thus to minimize the residual risks. For that purpose an approach is proposed, it is based on a continuous primary prevention strategy, which constitutes a first layer of the protection and is supported by some control and monitoring mechanisms of the critical risks. This approach is illustrated via a real case of study. It is carried out at the hemodialysis center at the teaching hospital, CHU-Batna Algeria

    Methods of diagnosis and treatment of postpartum uterine infection adopted by Algerian veterinarians

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    peer reviewedAbstract: The present study aimed to monitor the practices of Algerian veterinarians in the diagnosis and treatment of puerperal metritis (PM) and clinical endometritis (CE) in cattle. For this purpose, a questionnaire was established and distributed to collect the information concerning veterinarian profiles and practices related to the diagnosis and treatment of PM and CE. The results showed that examinations of the uterus (rectal palpation), vaginal discharge, and rectal temperature were the most practiced methods for PM (71%, 68%, and 83%, respectively) and CE (86%, 60%, and 65%, respectively) diagnosis. Tetracycline was the antibiotic of choice for intrauterine treatment of PM (54%) and CE (57%), whereas penicillin was the preferred parenteral antibiotic against PM (68%) and CE (64%). In addition, molecules combined with antibiotic treatment were PGF2α (PM: 71%, CE: 79%), vitamins (PM: 73%, CE: 60.5%), and nonsteroidal antiinflammatory drugs (PM: 68.2%, CE: 58%). Inseminators were more likely to use IU cephalosporins to treat PM and CE (OR = 3.5, P < 0.05 and OR = 5.1, P < 0.01, respectively). Veterinarians with more than 10 years of experience were more likely to use IU cephalosporins to treat PM (OR = 3.8, P = 0.03). Moreover, bovine practitioners were less likely to observe hyperthermia in cases of CE (OR = 0.29, P = 0.02)

    Outbreak of OXA-48-Producing Klebsiella pneumoniae Involving a Sequence Type 101 Clone in Batna University Hospital, Algeria

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    International audienceSeven nonredundant ertapenem-resistant Klebsiella pneumoniae isolates were collected between May 2014 and 19 January 2015 in the nephrology and hematology units of Batna University Hospital in Algeria. All strains coproduced the bla(OXA-48), bla(CTX-M-15), bla(SHV-1), and bla(TEM-1D) genes. Six of these isolates belonged to the pandemic clone sequence type 101 (ST101). The bla(OXA-48) gene was located on a conjugative IncL/M-type plasmid. This is the first known outbreak of OXA-48-producing K. pneumoniae isolates involving an ST101 clone in Batna University Hospital

    Prevalence, seasonality, and antimicrobial resistance of thermotolerant Campylobacter isolated from broiler farms and slaughterhouses in East Algeria

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    Aim: The current study was carried out to determine the prevalence, seasonality, and antimicrobial profile of thermotolerant Campylobacter isolated from broiler chickens in Batna, East Algeria, from June 2016 to June 2018. Materials and Methods: A total of 960 samples, including 480 cloacal swabs, 240 cecal contents, and 240 neck skin samples collected from 6 poultry farms and 12 slaughterhouses, were included in this study. After isolation and identification, susceptibility to seven antimicrobial agents was tested by the disk diffusion method. The seasonality of Campylobacter infection at broiler farms was statistically analyzed. Results: The data showed that 65%, 55%, and 70% of the cloacal swab, neck skin, and cecal content samples were contaminated with thermotolerant Campylobacter strains, respectively (p<0.05). Among the isolated campylobacteria, Campylobacter jejuni was the predominant species (73.5%). Sampling season exhibited a significant impact on the prevalence of Campylobacter (p<0.01), with peak occurrence in summer. All of the isolates were susceptible to gentamicin and resistant to ampicillin and amoxicillin/clavulanic acid, while 83.3% of them were resistant to erythromycin. Interestingly, 16 different resistance profiles were noted, with the combination of "ampicillin, amoxicillin/clavulanic acid, chloramphenicol, erythromycin, and tetracycline" being the most common, identified in 20.7% of isolated strains. Conclusion: This study demonstrates the presence of a high contamination rate of multidrug-resistant Campylobacter in farms and slaughterhouses in East Algeria. These findings underscore the need to apply strict control measures to avoid any associated public health hazard among Algerian consumers. This initial finding of the contamination of poultry with this zoonotic pathogen in East Algeria suggests the value of periodic comprehensive evaluation of associated disease in poultry as well as in humans in this region

    Chemical composition, antioxidant and antibacterial properties of <i>Pteranthus dichotomus</i> from Algerian Sahara

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    <div><p>The phytochemical study of ethyl acetate and <i>n</i>-butanol extracts of <i>Pteranthus dichotomus</i> Forssk. led to the isolation and identification of 11 compounds, including three glycolipids <b>1</b>–<b>3</b>, one lignan <b>4</b>, three flavonoids <b>5</b>–<b>7</b> and four phytosterols <b>8</b>–<b>11</b>. Structures of the isolated compounds have been elucidated by analysis of 1D and 2D NMR data, and mass spectrometry EI-MS and ESI-MS and by comparison with literature data. Furthermore, the ethyl acetate and <i>n</i>-butanol extracts were examined for their antioxidant and antibacterial activities. The results showed that both extracts (<i>PD</i>AC and <i>PD</i>BU) had a moderate antioxidant activity (IC50 = 375.514 μg/mL and 691.333 μg/mL) respectively.</p></div
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