Cent ans d’études balzaciennes au Japon

1. La traduction japonaise de Balzac et les études balzaciennes au Japon. Avant d’aborder les études balzaciennes au Japon, commençons d’abord par faire l’historique de l’influence européenne sur la culture japonaise. Le Japon a ouvert ses portes aux étrangers en l’occurrence les Européens, vers 1855. La civilisation européenne a été assimilée très rapidement par la société japonaise. Le nouveau gouvernement, qui venait de triompher de la guerre civile, s’est efforcé pendant dix années d’intr..

Immunohistochemical Study of Dendritic Cells and Kupffer Cells in Griseofulvin-Induced Protoporphyric Mice

To determine whether protoporphyric liver injury affects hepatic dendritic cells (DC) and Kupffer cells, we examined liver tissues of griseofulvin-induced protoporphyric mice using histological and immunohistochemical methods. After 1 week of griseofulvin feeding, the protoporphyric liver showed prominent hepatomegaly and a gradual increase in histopathological changes such as hepatocellular hypertrophy, focal necrosis and brown pigment deposits. After 4 weeks of treatment, marked ductular reaction was observed in the liver tissue. Immunohistochemical analyses indicated that the density of NLDC-145-positive hepatic DC gradually decreased during griseofulvin feeding. However, the index of the number of DC in the whole liver appeared to fall sharply after 6 weeks. In contrast, the density of F4/80-positive Kupffer cells gradually increased during griseofulvin feeding. In the spleen and lung, no significant differences were noted in the distribution of NLDC-145-positive DC between experimental and control mice. These results suggested that griseofulvin-induced protoporphyria leads to a specific decrease in the density of hepatic DC due to hepatomegaly until 4 weeks of treatment and is substantial after 6 weeks. This substantial decrease of hepatic DC might have been induced by some alterations in protoporphyric liver injury including ductular reaction at a later stage in this experiment. Since hepatic DC were reduced in number, they seemed to have no significant relation to the progression of griseofulvin-induced protoporphyric liver injury. However, the decrease of hepatic DC might affect the cellular immune response in protoporphyria