974 research outputs found
Nonlinear dynamics of self-centring rocking steel frames using finite element models
Rocking post-tensioned steel frames capitalise on the use of rocking joints, and unbonded post-tensioning strands to provide self-centring action. Investigations on the complex and unconventional nonlinear dy- namics of tied rocking steel frames, exclusive of supplemental damping methods, are presently limited. Increasing levels of energy-dissipation reduce the probability of observing nonlinear dynamic phenomena such as co-existing (high/low) amplitude responses at and around the systemâs nonlinear resonance. To this end, a finite element (FE) modelling framework is presented, validated and extended to multi-storey steel buildings. It is shown that the simulation strategies proposed enable an accurate representation of the complex nonlinear dynamics of self-centring structures, over a wide range of excitation frequencies and amplitudes. The methodology, applied to multi-storey steel frames, captures the presence of sub-harmonic resonances and higher-modes. It is also demonstrated that the additional demands observed in the rocking columns are the consequence of the asymmetry of the member boundary conditions
Computational Modelling Strategies for Nonlinear Response Prediction of Corroded Circular RC Bridge Piers
A numerical model is presented that enables simulation of the nonlinear flexural response of corroded reinforced concrete (RC) components. The model employs a force-based nonlinear fibre beam-column element. A new phenomenological uniaxial material model for corroded reinforcing steel is used. This model accounts for the impact of corrosion on buckling strength, post-buckling behaviour and low-cycle fatigue degradation of vertical reinforcement under cyclic loading. The basic material model is validated through comparison of simulated and observed response for uncorroded RC columns. The model is used to explore the impact of corrosion on the inelastic response of corroded RC columns
Nonlinear fiber element modeling of RC bridge piers considering inelastic buckling of reinforcement
An advanced modelling technique is developed to model the nonlinear cyclic response of circular RC columns using fibre-based section discretisation method. A comparison between different reinforcing steel models is made. Through a comprehensive parametric study the influence of inelastic buckling of vertical reinforcement on the cyclic response of circular RC columns is investigated. The results have been compared and validated against a set of experimental datasets. The proposed calibrated model accounts for the influence of inelastic buckling of vertical reinforcement and interaction of stiffness of horizontal ties reinforcement with vertical reinforcement. The model also accounts for the fracture of vertical bars due to low-cycle high-amplitude fatigue degradation. Therefore, this model is able to predict the nonlinear cyclic response of circular RC columns up to complete collapse. The results show that the existing uniaxial material models of reinforcing bars that are calibrated using stress-strain behaviour of isolated bars cannot represent the behaviour of reinforcing bars inside RC columns. Moreover, it is found that the buckling length of vertical reinforcement has a significant influence on the pinching response of RC columns and also reduces the low-cycle fatigue life of buckled reinforcemen
The Omega deformed B-model for rigid N=2 theories
We give an interpretation of the Omega deformed B-model that leads naturally
to the generalized holomorphic anomaly equations. Direct integration of the
latter calculates topological amplitudes of four dimensional rigid N=2 theories
explicitly in general Omega-backgrounds in terms of modular forms. These
amplitudes encode the refined BPS spectrum as well as new gravitational
couplings in the effective action of N=2 supersymmetric theories. The rigid N=2
field theories we focus on are the conformal rank one N=2 Seiberg-Witten
theories. The failure of holomorphicity is milder in the conformal cases, but
fixing the holomorphic ambiguity is only possible upon mass deformation. Our
formalism applies irrespectively of whether a Lagrangian formulation exists. In
the class of rigid N=2 theories arising from compactifications on local
Calabi-Yau manifolds, we consider the theory of local P2. We calculate motivic
Donaldson-Thomas invariants for this geometry and make predictions for
generalized Gromov-Witten invariants at the orbifold point.Comment: 73 pages, no figures, references added and typos correcte
Counting fermionic zero modes on M5 with fluxes
We study the Dirac equation on an M5 brane wrapped on a divisor in a
Calabi--Yau fourfold in the presence of background flux. We reduce the
computation of the normal bundle U(1) anomaly to counting the solutions of a
finite--dimensional linear system on cohomology. This system depends on the
choice of flux. In an example, we find that the presence of flux changes the
anomaly and allows instanton corrections to the superpotential which would
otherwise be absent.Comment: 14 pages. v2: reference added, typos corrected, few change
Prevalence of major depression in preschool children
The prevalence of preschool major depressive disorder (MDD) was studied in the community. The whole population of children between 3 and 6 years attending preschool nurseries in three areas (one urban, one rural and one suburban) in Spain (n = 1,427) were contacted. Selection was by a two-stage procedure. At stage I, the ESDM 3-6, a screening measure for preschool depression, was used to identify a sample for more intensive interviewing. Sensitivity and specificity of the cut-off point of the ESDM 3â6 had been previously tested in a pilot study (n = 229). During the first stage, 222 preschool children (15.6%) were found to be probable depressives, because they scored 27 or more, the cut-off used. At stage II, the children were interviewed and diagnosed by the consensus of two clinicians, blind to the ESDM 3-6 results. DSM-IV diagnostic criteria were used to define caseness. A total of 16 children (1.12%) met the MDD criteria. The prevalence by areas was urban 0.87%, rural 0.88%, suburban 1.43%. Sex distribution prevalence was 1:1. This study is a contribution to the scarce epidemiology of preschool depression in the community
Surface Operator, Bubbling Calabi-Yau and AGT Relation
Surface operators in N=2 four-dimensional gauge theories are interesting
half-BPS objects. These operators inherit the connection of gauge theory with
the Liouville conformal field theory, which was discovered by Alday, Gaiotto
and Tachikawa. Moreover it has been proposed that toric branes in the A-model
topological strings lead to surface operators via the geometric engineering. We
analyze the surface operators by making good use of topological string theory.
Starting from this point of view, we propose that the wave-function behavior of
the topological open string amplitudes geometrically engineers the surface
operator partition functions and the Gaiotto curves of corresponding gauge
theories. We then study a peculiar feature that the surface operator
corresponds to the insertion of the degenerate fields in the conformal field
theory side. We show that this aspect can be realized as the geometric
transition in topological string theory, and the insertion of a surface
operator leads to the bubbling of the toric Calabi-Yau geometry.Comment: 36 pages, 14 figures. v2: minor changes and typos correcte
Systemic tuberculosis presenting with acute transient myopia: a case report
<p>Abstract</p> <p>Introduction</p> <p>Transient myopia has been reported to occur in a number of conditions, either ocular in origin or associated with an underlying systemic cause. We present a rare case of this abnormality occurring in the setting of systemic tuberculosis.</p> <p>Case presentation</p> <p>A 29-year-old Indian woman presented with sudden onset blurred distance vision and fever. Examination revealed visual acuity of counting fingers in both eyes improving to 6/9 with pinhole with N5 reading acuity. Anterior segment examination revealed narrow angles on gonioscopy. Posterior segments were normal. Systemic examination revealed a fluctuant mass in her left loin, aspiration of which yielded pus which was culture-positive for <it>Mycobacterium tuberculosis</it>. The Mantoux test elicited a strongly positive reaction. Chest X-ray and magnetic resonance imaging of the brain were unremarkable. Computed tomography scan and magnetic resonance imaging of the spine and abdomen revealed a large psoas abscess communicating with the loin mass. Two vertebrae were involved but not the spinal cord or canal.</p> <p>Conclusion</p> <p>Transient myopia is a rare presenting feature of systemic tuberculosis. A postulated mechanism in this patient is that development of a uveal effusion related to systemic tuberculosis caused anterior rotation of the iris-lens diaphragm, thereby inducing narrowing of the angle and acute myopia.</p
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Reduced disease severity following therapeutic treatment with angiotensin 1-7 in a mouse model of multiple sclerosis
Multiple Sclerosis (MS) is a chronic disease of the central nervous system (CNS) characterized by autoimmune and neurodegenerative pathologies for which there is no cure and no defined etiology. Although several, modestly effective, disease modifying drugs are available to treat MS, there are presently no treatments that offer neuroprotection and prevent clinical progression. Therapies are needed that control immune homeostasis, prevent disease progression, and stimulate regeneration in the CNS. Components of the renin-angiotensin-system (RAS) have recently been identified as chemical mediators in the CNS and in neurological disease. Here we show the beneficial effect of therapeutic treatment with the Mas receptor agonist and metabolite of the protective arm of RAS, angiotensin 1-7 (A(1-7)), in the experimental autoimmune encephalomyelitis (EAE) animal model of MS. Therapeutic treatment with A(1-7) caused a dose-dependent reduction both in clinical disease severity and progression, and was dependent on Mas receptor activation. Further analysis of the most optimal dose of A(1-7) treatment revealed that the reductions in clinical disease course were associated with decreased immune infiltration and demyelination, axonal loss and oxidative stress in the spinal cord. In addition A(1-7) treatment was also associated with increases in circulating alternatively activated monocytes/macrophages.Department of Defense, USC Clinical and Translational Science Institute, National Multiple Sclerosis Society12 month embargo; available online 25 February 2019.This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]
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