59 research outputs found
Ultra-Slow Light and Enhanced Nonlinear Optical Effects in a Coherently Driven Hot Atomic Gas
We report the observation of small group velocities of order 90 meters per
second, and large group delays of greater than 0.26 ms, in an optically dense
hot rubidium gas (~360 K). Media of this kind yield strong nonlinear
interactions between very weak optical fields, and very sharp spectral
features. The result is in agreement with previous studies on nonlinear
spectroscopy of dense coherent media
A stationary source of non-classical or entangled atoms
A scheme for generating continuous beams of atoms in non-classical or
entangled quantum states is proposed and analyzed. For this the recently
suggested transfer technique of quantum states from light fields to collective
atomic excitation by Stimulated Raman adiabatic passage [M.Fleischhauer and
M.D. Lukin, Phys.Rev.Lett. 84, 5094 (2000)] is employed and extended to matter
waves
Low-light-level nonlinear optics with slow light
Electromagnetically induced transparency in an optically thick, cold medium
creates a unique system where pulse-propagation velocities may be orders of
magnitude less than and optical nonlinearities become exceedingly large. As
a result, nonlinear processes may be efficient at low-light levels. Using an
atomic system with three, independent channels, we demonstrate a quantum
interference switch where a laser pulse with an energy density of
photons per causes a 1/e absorption of a second pulse.Comment: to be published in PR
Drag in paired electron-hole layers
We investigate transresistance effects in electron-hole double layer systems
with an excitonic condensate. Our theory is based on the use of a minimum
dissipation premise to fix the current carried by the condensate. We find that
the drag resistance jumps discontinuously at the condensation temperature and
diverges as the temperature approaches zero.Comment: 12 pages, 1 Figure, .eps file attache
Optical imaging beyond the diffraction limit via dark states
We study the possibility of creating spatial patterns having subwavelength
size by using the so-called dark states formed by the interaction between atoms
and optical fields. These optical fields have a specified spatial distribution.
Our experiments in Rb vapor display spatial patterns that are smaller than the
length determined by the diffraction limit of the optical system used in the
experiment. This approach may have applications to interference lithography and
might be used in coherent Raman spectroscopy to create patterns with
subwavelength spatial resolution.Comment: 5 pages, 5 figure
Carrier-Envelope Phase Effect on Atomic Excitation by Few-Cycle rf Pulses
Article on carrier-envelope phase effect on atomic excitation by few-cycle rf pulses
Observation of picosecond superfluorescent pulses in rubidium atomic vapor pumped by 100-fs laser pulses
Journals published by the American Physical Society can be found at http://publish.aps.org/We study the superfluorescence (SF) from a gas of rubidium atoms. The atoms of a dense vapor are excited to the 5D state from the 5S state by a two-photon process driven by 100-fs laser pulses. The atoms decay to the 6P state and then to the 5S state. The SF emission at 420 nm on the 6P-5S transition is recorded by a streak camera with picosecond time resolution. The time duration of the generated SF is tens of picoseconds, which is much shorter than the time scale of the usual relaxation processes, including spontaneous emission and atomic coherence dephasing. The dependence of the time delay between the reference input pulse and SF is measured as a function of laser power. The experimental data are described quantitatively by a simulation based on the semiclassical atom-field interaction theory. The observed change in scaling laws for the peak intensity and delay time can be elucidated by an SF theory in which the sample length is larger than the cooperation length
Signal Transduction Pathways in the Pentameric Ligand-Gated Ion Channels
The mechanisms of allosteric action within pentameric ligand-gated ion channels (pLGICs) remain to be determined. Using crystallography, site-directed mutagenesis, and two-electrode voltage clamp measurements, we identified two functionally relevant sites in the extracellular (EC) domain of the bacterial pLGIC from Gloeobacter violaceus (GLIC). One site is at the C-loop region, where the NQN mutation (D91N, E177Q, and D178N) eliminated inter-subunit salt bridges in the open-channel GLIC structure and thereby shifted the channel activation to a higher agonist concentration. The other site is below the C-loop, where binding of the anesthetic ketamine inhibited GLIC currents in a concentration dependent manner. To understand how a perturbation signal in the EC domain, either resulting from the NQN mutation or ketamine binding, is transduced to the channel gate, we have used the Perturbation-based Markovian Transmission (PMT) model to determine dynamic responses of the GLIC channel and signaling pathways upon initial perturbations in the EC domain of GLIC. Despite the existence of many possible routes for the initial perturbation signal to reach the channel gate, the PMT model in combination with Yen's algorithm revealed that perturbation signals with the highest probability flow travel either via the β1-β2 loop or through pre-TM1. The β1-β2 loop occurs in either intra- or inter-subunit pathways, while pre-TM1 occurs exclusively in inter-subunit pathways. Residues involved in both types of pathways are well supported by previous experimental data on nAChR. The direct coupling between pre-TM1 and TM2 of the adjacent subunit adds new insight into the allosteric signaling mechanism in pLGICs. © 2013 Mowrey et al
DREADD agonist 21 is an effective agonist for muscarinic-based DREADDs in vitro and in vivo
Chemogenetic tools such as designer receptors exclusively activated by designer drugs (DREADDs) are routinely used to modulate neuronal and non-neuronal signaling and activity in a relatively noninvasive manner. The first generation of DREADDs were templated from the human muscarinic acetylcholine receptor family and are relatively insensitive to the endogenous agonist acetylcholine but instead are activated by clozapine-N-oxide (CNO). Despite the undisputed success of CNO as an activator of muscarinic DREADDs, it has been known for some time that CNO is subject to a low rate of metabolic conversion to clozapine, raising the need for alternative chemical actuators of muscarinic-based DREADDs. Here we show that DREADD agonist 21 (C21) (11-(1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine) is a potent and selective agonist at both excitatory (hM3Dq) and inhibitory (hM4Di) DREADDs and has excellent bioavailability, pharmacokinetic properties, and brain penetrability. We also show that C21-induced activation of hM3Dq and hM4Di in vivo can modulate bidirectional feeding in defined circuits in mice. These results indicate that C21 represents an alternative to CNO for in vivo studies where metabolic conversion of CNO to clozapine is a concern
Distinct Subpopulations of Nucleus Accumbens Dynorphin Neurons Drive Aversion and Reward
The nucleus accumbens (NAc) and the dynorphinergic system are widely implicated in motivated behaviors. Prior studies have shown that activation of the dynorphin-kappa opioid receptor (KOR) system leads to aversive, dysphoria-like behavior. However, the endogenous sources of dynorphin in these circuits remain unknown. We investigated whether dynorphinergic neuronal firing in the NAc is sufficient to induce aversive behaviors. We found that photostimulation of dynorphinergic cells in the ventral NAc shell elicits robust conditioned and real-time aversive behavior via KOR activation, and in contrast, photostimulation of dorsal NAc shell dynorphin cells induced a KOR-mediated place preference and were positively reinforcing. These results show previously unknown discrete subregions of dynorphin-containing cells in the NAc shell that selectively drive opposing behaviors. Understanding the discrete regional specificity by which NAc dynorphinerigic cells regulate preference and aversion provides insight into motivated behaviors that are dysregulated in stress, reward, and psychiatric disease
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