58 research outputs found
Radio-induced low-grade glioma: report of two cases and review of the literature
With the increasing number of cancer survivors,
we can observe a population that will present a higher
risk of developing secondary long-term toxicities related to
adjuvant chemo and radiotherapy regimens. Among these,
children surviving from acute lymphoblastic leukemia
(ALL) that were treated with prophylactic cranial irradiation
represent a group of patients at a high risk of
developing secondary brain tumors. Radiation-induced
intracranial tumors have been documented since 1950, and
today, more than one-hundred cases have been described.
We report our experience with two young patients who
were hospitalized for low grade gliomas and had a positive
anamnesis for ALL and consequent radiotherapy
Metabolism of no-carrier-added 2-[18F]fluoro-L-tyrosine in rats
Background: Several fluorine-18 labelled fluoroamino acids have been evaluated as tracers for the quantitative assessment of cerebral protein synthesis in vivo by positron emission tomography (PET). Among these, 2-[18F]fluoro-L-tyrosine (2-[18F]Tyr) has been studied in mice at a low specific activity. Its incorporation into proteins is fast and metabolism via other pathways is limited. The present in vivo study was carried out in normal awake rats using no-carrier-added 2-[18F]Tyr. Under normal physiological conditions, we have studied the incorporation into proteins and the metabolism of the tracer in different brain areas.
Methods: No-carrier-added 2-[18F]Tyr was administered to awake rats equipped with chronic
arterial and venous catheters. The time course of the plasma activity was studied by arterial blood sampling. The biodistribution of the activity in the main organs was studied at the end of the
experiment. The distribution of radioactive species in plasma and brain regions was studied by
acidic precipitation of the proteins and HPLC analysis of the supernatant.
Results: The absolute uptake of radioactivity in brain regions was homogenous. In awake rats, nocarrier-added 2-[18F]Tyr exhibits a fast and almost quantitative incorporation into the proteins
fractions of cerebellum and cortex. In striatum, this incorporation into proteins and the unchanged
fraction of the tracer detected by HPLC could be lower than in other brain regions.
Conclusion: This study confirms the potential of 2-[18F]fluoro-L-tyrosine as a tracer for the
assessment of the rate of protein synthesis by positron emission tomography. The observed
metabolism suggests a need for a correction for the appearance of metabolites, at least in plasma
In vivo incorporation of labelled methionine into proteins in brain tumors
CapÃtulo en: B.M. Mazoyer; W.D: Heiss; D. Comar (eds.). PET Studies on Amino Acid Metabolism and Protein Synthesis : Proceedings of a Workshop held in Lyon, France, within the framework of the European Community Medical and Public Health Research. Dordrecht: Springer, 1993, p.265-268. (Developments in Nuclear Medicine ; 23). ISBN 978-94-010-4706-7. ISBN 978-94-011-1620-6. DOI 10.1007/978-94-011-1620-6_22The incorporation of L-(14C-methyl) methionine into proteins was studied in two subjects presenting brain glioma. Comparing to normal brain tissue, an increased methionine metabolic activity was found in the tumors, with most of the tissue radioactivity incorporated into proteinsPeer Reviewe
Radiochemical Synthesis and Evaluation of 13NLabeled 5Aminolevulinic Acid for PET Imaging of Gliomas
Combined functional neuroimaging (fMRI and MEG) for the guidance of epidural motor cortex stimulation in chronic refractory neuropathic pain: a pilot study.
info:eu-repo/semantics/nonPublishe
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