Phenotypes of pseudomonas aeruginosa strains, isolated in surgical clinics

After studying of 83 strains of P. aeruginosa we revealed the phenotypic heterogeneity (in phospholipase activity, biofilm-forming capacity, resistance to antibiotics et al.) of bacterial populations both in different departments within one multi-specialized clinic and in different surgical clinics. We determined, that strains, isolated from intensive care unit, have the largest number of expressive pathogenic factors and high multiple drug resistance. The likeness or difference of phenotypic characteristics of P. aeruginosa, which is inductive, don't let us estimate definitely the possibility of strain migration from the intensive care unit into another departments of the multi-specialized clinic, as we don't know clearly if the heterogeneity of population of P. aeruginosa is conditioned by modified variability or its differences are fixed in the genome. Permanently preserved conditions and typical contingent of patients in specialized departments contribute to the forming of profiled phenotypes among the isolated strains.В результате изучения 83 штаммов P. aeruginosa, выявлена фенотипическая гетерогенность (по фосфолипазной, пленкообразующей способности, антибиотикорезистентности и др.) популяций синегнойной палочки в различных отделениях одного многопрофильного, а также в разных хирургических стационарах г. Перми. Установлено, что штаммы, изолированные из ОРИТ, характеризуются наиболее широким набором экспрессируемых факторов патогенности и выраженной множественной лекарственной устойчивостью. Сходство или различие фенотипических характеристик изолятов P. aeruginosa, проявление которых в значительной степени индуцибельно, не позволяют однозначно оценить вероятность миграции штаммов, изолированных в ОРИТ, в другие отделения многопрофильного хирургического стационара, поскольку не ясно, обусловлена ли гетерогенность популяций синегнойной палочки модификационной изменчивостью или их отличия закреплены в геноме. Перманентно сохраняющиеся условия и типичные контингенты специализированных отделений способствуют формированию среди изолируемых в них культур профилированных фенотипов

Dosimetry for boron neutron capture therapy developed and verified at the accelerator based neutron source VITA

The method of boron neutron capture therapy for malignant tumors, proposed in 1936, is beginning to enter clinical practice. The development of dosimetry tools for characterization of therapeutic mixed neutron-photon beam and assessing the patient’s response to treatment is becoming relevant. In this work, a number of dosimetric techniques have been developed: a compact neutron detector with a pair of cast scintillators, one of which is enriched with boron, to measure the boron dose and the γ-ray dose; cell dosimeter for measuring the sum of the equivalent dose of fast neutrons and the equivalent nitrogen dose; prompt γ-ray spectroscopy for in situ measurement of boron dose in real time; epithermal neutron flux monitor for measuring the epithermal neutron flux. Their verification carried out on the accelerator based neutron source VITA showed that they can become convenient and reliable tools for characterization of neutron beam and assessing the patient’s response to treatment

Public-Private Partnership in the Implementation of the Industrial Policy of Russia

The article views the creation of public-private partnership as an important direction in the activation of the innovative type of the development of the economy of Russia. The need to combine the efforts of the public and private business in solving this problem is connected, firstly, with the economic sanctions of the West and not only financial sanctions but also with the refusal to supply high-tech equipment to Russia and, secondly, even more threatening prospects of the dynamics of the innovative development of the manufacturing sector. That is why the main attention is paid to the impact of public-private partnership on the development of integrated business in the context of the implementation of the strategic task of the innovative way of the Russian economy development. It is shown that public-private partnerships are one of the most common instruments for attracting private investments in infrastructure projects both in Russia and abroad. But the format of public-private partnerships for the implementation of Russia's industrial policy in the field of innovation should be used not only for the infrastructure development but also for the development of Russian industrial enterprises and the implementation of national projects

"Property" in the Treatises of British Lawyers 12-13 Centuries (the Problem of the Reception of Roman Law)

Автор статьи на основе анализа средневековых текстов раскрывает значение терминов dominium и property в XII-XIII вв. The author based on an analysis of medieval texts reveals the meaning of terms dominium and property in the 12-13 centuries

Nanocomposite Materials Based on Polylactide and Gold Complex Compounds for Absorbed Dose Diagnostics in BNCT

In this study, approaches to the synthesis of complex compound of gold with cysteine [AuCys]n for measuring absorbed dose in boron neutron capture therapy (BNCT) were developed. The dependence of the complex particle size on pH were established. Nanocomposite materials based on polylactide containing [AuCys]n particles with an average size of about 20 nm were obtained using the crazing mechanism. The structure of obtained materials was studied by electron microscopy. The release kinetics of [AuCys]n from polymer matrix were investigated. Release of [AuCys]n from the volume of the polymeric matrix had a delayed start—this process began only after 24 h and was characterized by an effective rate constant of 1 μg/h from a 20 mg composite sample. At the same time, in vitro studies showed that the concentration of 6.25 μg/mL was reliably safe and did not reduce the survival of U251 and SW-620 cells

In situ study of thermal shock damage to high-temperature ceramics

New generations of fusion devices need alternative plasma-facing materials. The currently approved material composition for the first wall and divertor of the ITER tokamak has a number of disadvantages: insufficient resistance to thermal shock, sputtering of microparticles into plasma and high atomic number Z of the armor material. A promising but largely untested idea is the proposal to use high-temperature ceramics as armor materials for the most heat-loaded plasma-facing components of new-generation fusion devices. Among the advantages of ceramics are the low Z and high enough resistance to intense heating. More research is needed that would help to understand how the material withstands high heat fluxes during transient plasma events. This work is devoted to the description of an experimental method that makes it possible to estimate the critical temperature at which the damage of ceramics begins as a result of a thermal shock of submillisecond duration. As a demonstration of the efficiency of the method, the critical temperature for hot pressed B4C under thermal shock was determined: its value was about 1200–1400 K