Biproducts without pointedness

We show how to define biproducts up to isomorphism in an arbitrary category without assuming any enrichment. The resulting notion coincides with the usual definitions whenever all binary biproducts exist or the category is suitably enriched, resulting in a modest yet strict generalization otherwise. We also characterize when a category has all binary biproducts in terms of an ambidextrous adjunction. Finally, we give some new examples of biproducts that our definition recognizes.Comment: 6 page

A comonadic view of simulation and quantum resources

We study simulation and quantum resources in the setting of the sheaf-theoretic approach to contextuality and non-locality. Resources are viewed behaviourally, as empirical models. In earlier work, a notion of morphism for these empirical models was proposed and studied. We generalize and simplify the earlier approach, by starting with a very simple notion of morphism, and then extending it to a more useful one by passing to a co-Kleisli category with respect to a comonad of measurement protocols. We show that these morphisms capture notions of simulation between empirical models obtained via `free' operations in a resource theory of contextuality, including the type of classical control used in measurement-based quantum computation schemes.Comment: To appear in Proceedings of LiCS 201

Uncloneable Quantum Advice

The famous no-cloning principle has been shown recently to enable a number of uncloneable functionalities. Here we address for the first time unkeyed quantum uncloneablity, via the study of a complexity-theoretic tool that enables a computation, but that is natively unkeyed: quantum advice. Remarkably, this is an application of the no-cloning principle in a context where the quantum states of interest are not chosen by a random process. We show the unconditional existence of promise problems admitting uncloneable quantum advice, and the existence of languages with uncloneable advice, assuming the feasibility of quantum copy-protecting certain functions. Along the way, we note that state complexity classes, introduced by Rosenthal and Yuen (ITCS 2022) - which concern the computational difficulty of synthesizing sequences of quantum states - can be naturally generalized to obtain state cloning complexity classes. We make initial observations on these classes, notably obtaining a result analogous to the existence of undecidable problems. Our proof technique establishes the existence of ingenerable sequences of finite bit strings - essentially meaning that they cannot be generated by any uniform circuit family. We then prove a generic result showing that the difficulty of accomplishing a computational task on uniformly random inputs implies its difficulty on any fixed, ingenerable sequence. We use this result to derandomize quantum cryptographic games that relate to cloning, and then incorporate a result of Kundu and Tan (arXiv 2022) to obtain uncloneable advice. Applying this two-step process to a monogamy-of-entanglement game yields a promise problem with uncloneable advice, and applying it to the quantum copy-protection of pseudorandom functions with super-logarithmic output lengths yields a language with uncloneable advice.Comment: 58 pages, 6 figure

Reversible Effects as Inverse Arrows

Reversible computing models settings in which all processes can be reversed. Applications include low-power computing, quantum computing, and robotics. It is unclear how to represent side-effects in this setting, because conventional methods need not respect reversibility. We model reversible effects by adapting Hughes' arrows to dagger arrows and inverse arrows. This captures several fundamental reversible effects, including serialization and mutable store computations. Whereas arrows are monoids in the category of profunctors, dagger arrows are involutive monoids in the category of profunctors, and inverse arrows satisfy certain additional properties. These semantics inform the design of functional reversible programs supporting side-effects.Comment: 15 pages; corrected Example 3.

Way of the dagger

A dagger category is a category equipped with a functorial way of reversing morphisms, i.e. a contravariant involutive identity-on-objects endofunctor. Dagger categories with additional structure have been studied under different names in categorical quantum mechanics, algebraic field theory and homological algebra, amongst others. In this thesis we study the dagger in its own right and show how basic category theory adapts to dagger categories. We develop a notion of a dagger limit that we show is suitable in the following ways: it subsumes special cases known from the literature; dagger limits are unique up to unitary isomorphism; a wide class of dagger limits can be built from a small selection of them; dagger limits of a fixed shape can be phrased as dagger adjoints to a diagonal functor; dagger limits can be built from ordinary limits in the presence of polar decomposition; dagger limits commute with dagger colimits in many cases. Using cofree dagger categories, the theory of dagger limits can be leveraged to provide an enrichment-free understanding of limit-colimit coincidences in ordinary category theory. We formalize the concept of an ambilimit, and show that it captures known cases. As a special case, we show how to define biproducts up to isomorphism in an arbitrary category without assuming any enrichment. Moreover, the limit-colimit coincidence from domain theory can be generalized to the unenriched setting and we show that, under suitable assumptions, a wide class of endofunctors has canonical fixed points. The theory of monads on dagger categories works best when all structure respects the dagger: the monad and adjunctions should preserve the dagger, and the monad and its algebras should satisfy the so-called Frobenius law. Then any monad resolves as an adjunction, with extremal solutions given by the categories of Kleisli and Frobenius- Eilenberg-Moore algebras, which again have a dagger. We use dagger categories to study reversible computing. Specifically, we model reversible effects by adapting Hughes’ arrows to dagger arrows and inverse arrows. This captures several fundamental reversible effects, including serialization and mutable store computations. Whereas arrows are monoids in the category of profunctors, dagger arrows are involutive monoids in the category of profunctors, and inverse arrows satisfy certain additional properties. These semantics inform the design of functional reversible programs supporting side-effects

Limits in dagger categories

We develop a notion of limit for dagger categories, that we show is suitable in the following ways: it subsumes special cases known from the literature; dagger limits are unique up to unitary isomorphism; a wide class of dagger limits can be built from a small selection of them; dagger limits of a fixed shape can be phrased as dagger adjoints to a diagonal functor; dagger limits can be built from ordinary limits in the presence of polar decomposition; dagger limits commute with dagger colimits in many cases

Monads on Dagger Categories

The theory of monads on categories equipped with a dagger (a contravariant identity-on-objects involutive endofunctor) works best when everything respects the dagger: the monad and adjunctions should preserve the dagger, and the monad and its algebras should satisfy the so-called Frobenius law. Then any monad resolves as an adjunction, with extremal solutions given by the categories of Kleisli and Frobenius-Eilenberg-Moore algebras, which again have a dagger. We characterize the Frobenius law as a coherence property between dagger and closure, and characterize strong such monads as being induced by Frobenius monoids.Comment: 28 page

Metronidazole and ursodeoxycholic acid for primary sclerosing cholangitis : A randomized placebo-controlled trial

No effective medical therapy is currently available for primary sclerosing cholangitis (PSC). Ursodeoxycholic acid (UDCA) improves liver enzymes, but its effect on liver histology is controversial. Metronidazole (MTZ) prevents PSC-like liver damage in animal models and reduces intestinal permeability. We recruited 80 patients with PSC into a randomized placebo-controlled study to evaluate the effect of UDCA and MTZ (UDCA/MTZ) compared with UDCA/placebo on the progression of PSC. Patients (41 UDCA/placebo and 39 UDCA/ MTZ) were followed every third month. Assessment of liver function test, histological stage and grade, and cholangiography (via ERCP) at baseline showed no differences between the groups. After 36 months, serum aminotransferases gamma-glutamyltransferase, and alkaline phosphatase (ALP) decreased markedly in both groups, serum ALP more significantly in the UDCA/MTZ group (-337 +/- 54 U/L, PPeer reviewe

Reversible Monadic Computing

AbstractWe extend categorical semantics of monadic programming to reversible computing, by considering monoidal closed dagger categories: the dagger gives reversibility, whereas closure gives higher-order expressivity. We demonstrate that Frobenius monads model the appropriate notion of coherence between the dagger and closure by reinforcing Cayley's theorem; by proving that effectful computations (Kleisli morphisms) are reversible precisely when the monad is Frobenius; by characterizing the largest reversible subcategory of Eilenberg–Moore algebras; and by identifying the latter algebras as measurements in our leading example of quantum computing. Strong Frobenius monads are characterized internally by Frobenius monoids