Tooth eruption and symptomatology: Are the symptoms assumed to be related to the tooth eruption really associated with teeth?

Despite little evidence, many various complaints might be associated with teething in children. Symptoms related with teething mostly result in delay diagnosis of underlying disease. In this study we explore the relationship between teething and symptoms commonly seen in pediatric clinics. Children less than 36 months of age, who came to Medipol University Faculty of Medicine, between October 2013 and May 2014 for routine well-child visit, were recruited in the study. At visit time 318 infants (60.5%) had one or more visible tooth eruption. Participants were divided in five subgroups according to their age. Parents of infants (mean age 11.5 months) completed questionnaires. The most commonly reported symptom was irritability in 12-18 months (74%), 24-30 months (57%) and 30-36 (44%) months’ periods, drooling in 6-12 months (87%), loss of appetite in 18-24 months (64%). Irritability was statistically significant in all groups except 18-24 month. (p=0.54). Febrile fever was only statistically significant in 6-12 and 12-18 months groups. Increase in biting was become statistically significant after 12 months. Although rates vary according to age group, many mild symptoms previously thought to be associated with teething were found temporally correlated with teething. Before parents/caregivers attribute these symptoms to tooth eruption other possible causes must be ruled out. © 2015, Yuzuncu Yil Universitesi Tip Fakultesi, Universitas Indonesia. All rights reserved

Detecting Peripheral Arterial Disease in Primary Care: A Population Based Study

Background: Peripheral arterial disease (PAD) can progress silently without any clinical symptoms. Ankle-brachial index (ABI) is the recommended method used in primary care. We aimed to determine the prevalence of PAD and its related risk factors in primary care

The Complex Genetic Landscape of Hereditary Ataxias in Turkey and Implications in Clinical Practice

Sahin, Erdi/0000-0002-5792-2888; Vural, Atay/0000-0003-3222-874X; Gul, Tugce/0000-0002-1818-9839WOS:000621079400001PubMed: 33624863Background The genetic and epidemiological features of hereditary ataxias have been reported in several populations; however, Turkey is still unexplored. Due to high consanguinity, recessive ataxias are more common in Turkey than in Western European populations. Objective To identify the prevalence and genetic structure of hereditary ataxias in the Turkish population. Methods Our cohort consisted of 1296 index cases and 324 affected family members. Polymerase chain reaction followed by Sanger sequencing or fragment analysis were performed to screen for the trinucleotide repeat expansions in families with a dominant inheritance pattern, as well as in sporadic cases. The expansion in the frataxin (FXN) gene was tested in all autosomal recessive cases and in sporadic cases with a compatible phenotype. Whole-exome sequencing was applied to 251 probands, selected based on the family history, age of onset, and phenotype. Results Mutations in known ataxia genes were identified in 30% of 1296 probands. Friedreich's ataxia was found to be the most common recessive ataxia in Turkey, followed by autosomal recessive spastic ataxia of Charlevoix-Saguenay. Spinocerebellar ataxia types 2 and 1 were the most common dominant ataxias. Whole-exome sequencing was performed in 251 probands with an approximate diagnostic yield of 50%. Forty-eight novel variants were found in a plethora of genes, suggesting a high heterogeneity. Variants of unknown significance were discussed in light of clinical data. Conclusion With the large sample size recruited across the country, we consider that our results provide an accurate picture of the frequency of hereditary ataxias in Turkey. (c) 2021 International Parkinson and Movement Disorder SocietySuna and Inan Kirac Foundation; Koc UniversityKoc University; Bogazici UniversityBogazici UniversityThis work was supported by funds from Suna and Inan Kirac Foundation, Koc University, Bogazici University

The influence of the sleep-wake cycle on primary monosymptomatic nocturnal enuresis: A non-randomized comparative study

Backround: Enuresis implies severe stress in affected children, and impairs quality of life and sleep. Children with enuresis experience difficulties in their arousal from sleep, possibly associated with disturbances of the circadian rhythm. In this study, we aimed to evaluate the sleep-wake cycle and sleep disturbances in children with monosymptomatic enuresis nocturna (MEN). Method: The study comprised 70 children with MEN who were admitted to the pediatrics and urology outpatients department and 94 age-matched healthy controls. Parents completed "Strengths and Difficulties Questionnaire," Children's Sleep Habits Questionnaire (CSHQ), Children's Chronotype Questionnaire scale. Results: Children with enuresis had significantly more sleep and psychological problem. Enuresis group reported higher bedtime resistance, parasomnias, breathing-related problems, and daytime sleepiness in CHSQ (p 0.05), sleep duration on school days and awakening and mid-sleep points, both on scheduled and free days, were found to be significantly different in the enuretic group (p < 0.05). In logistic regression analysis, age, sleep period on scheduled days, sleep inertia on scheduled and free days were significant predictor for enuresis. Discussion: Children with enuresis were more likely to experience problematic sleep. This may reflect that enuretic children have impaired sleep-wake cycles, leading to dysregulation of daily functional changes of bladder capacity and related hormones such as ADH. These findings might imply a sleep-wake disturbance in enuresis

Postpartum depression in mothers of babies with infantile colic

Amaç: Doğum sonrası depresyon, hem anne hem de çocukta birçok soruna yol açarak anne-çocuk ilişkisini, annenin bakım verme ve ebeveynlik becerilerini olumsuz etkiler. Erken çocukluk döneminde görülen sorunlardan biri de infantil koliktir (İK). Bu çalışmamızda İK ile postpartum depresyon (PPD) arasındaki ilişki araştırılmıştır. Yöntem: Çalışmamızda 3 aylıktan küçük bebeklerin anneleri (n=102) Edinburgh Doğum Sonrası Depresyon Ölçeği (EDSDÖ) ile değerlendirilmiştir. Bulgular: İK olan bebeklerin (n=55) annelerinde EDSDÖ skor ortalaması (12,7±4,8) İK olmayanlara (n=47) göre (8,44±5,62) anlamlı derecede yüksek bulunmuştur (p<0.001). Daha genç annelerde depresyon skorunun arttığı görülmüş, buna karşın eğitim seviyesi, sahip olunan çocuk sayısı, çalışma hayatına dönüş süresi ve beslenme tipleri ile EDSDÖ skoru arasında bir ilişki bulunamamıştır. Tartışma: İK yakınması olan bebeklerin annelerinin depresyon açısından değerlendirilmesi anne-çocuk sağlığı açısından önemlidir.Objective: Postpartum depression leads to mother-child relationship problems, impairment of maternal caregiving and parenting skills in both mother and child. Infantile colic (IC) is one of the important problems in early childhood. In this study we investigated the relationship between postpartum depression and IC. Method: In our study, mothers of infants younger than 3 months (n=102) were evaluated with Edinburgh Post Partum Depression Scale (EPDS). Results: EPDS mean scores of IC (n=55) group were significantly higher than those without IC (n=47) group (respectively, 12,7±4,8; 8,44±5,62) (p<0.001). Younger maternal age was correlated with higher EPDS scores, whereas the level of education, number of children, returning to job and feeding types were not correlated with EPDS. Discussion: IC symptoms may imply unrecognized maternal depression, it must be considered in terms of the mother-child mental health

Prevalence of Prader-Willi Syndrome among Infants with Hypotonia

Objective To investigate the prevalence of Prader-Willi syndrome (PWS) in infants with hypotonia between the ages of 0 and 2 years

Hematopoietic stem cell transplantation in refractory or recurrent lymphomas of children and adolescents: a multicenter survey of Turkish pediatric BTM study group

...European Group for Blood and Marrow Transplantatio

Covid-19 infection in children with cancer after the first wave in Turkey: A study of the Turkish pediatric oncology (TPOG) and hematology (TPHD) societies

..