Reversed-phase high performance liquid chromatography study of lipophilicity of imidazo[2,1-f]theophylline derivatives

The present study is a part of our physicochemical and pharmacological studies in a group of tricyclic theophylline derivatives. The investigated compounds exhibit different pharmacological profiles in comparison to theophylline and have been tested as potential antidepressant and/or antipsychotic agents. The differences in pharmacological action between theophylline and their tricyclic derivatives can be explained by their various physicochemical properties, especially lipophilicity. The chromatographic behavior of twenty three derivatives of imidazo[2,1-f]theophylline was investigated, using reversed-phase high performance liquid chromatography (RP-HPLC) method. Moreover, partition coefficients and selected pharmacokinetic parameters were calculated computationally. Principal component analysis (PCA) method was used to establish the relationship between obtained experimental and computational parameters

Thermal imaging and planimetry evaluation of the results of chronic wounds treatment with hyperbaric oxygen therapy

Background. One of the methods to treat chronic wounds is the use of hyperbaric oxygen (HBO). Objective measurement of the wound surface is an important element in the process of monitoring and predicting the progress of treatment. Objectives. The aim of the study was to evaluate the effect of hyperbaric oxygen therapy (HBOT) on ulcer wound healing in patients with chronic venous insufficiency ulcers and diabetic foot syndrome using thermal imaging and computerized planimetry. Material and methods. During a 3-year period, 284 digital computer planimetry measurements were gathered from 142 patients treated for leg ulcers caused by chronic venous insufficiency and ulcers from diabetic foot syndrome at HBOT Unit of the Dr Stanisław Sakiel Centre for Burns Treatment in Siemianowice Śląskie (Poland). Each patient took 30 HBOT sessions using a Haux multiplace HBO chamber at a pressure of 2.5 atmospheres absolute (ATA). The results of the treatment were monitored using thermovision and computerassisted planimetry measurements performed before and after HBOT. Results. Both groups of patients exhibited a reduction in the surface and perimeter of the wound after HBOT. The treatment effects were also confirmed with thermal imaging. The areas calculated from thermal imaging and planimetry are different but correlated. Conclusions. It seems that a combination of thermal imaging and planimetry may enhance the diagnosis as well as provide the physician with more information about therapy effects

Emergency management of the patient after thermal burn

Wstęp. Ciężkie oparzenia stanowią duży problem w medycynie. Ciężkie oparzenia pociągają za sobą wielokierunkowe zaburzenia ogólnoustrojowe, których leczenie może stać się bardzo trudne dla ratownika medycznego. Duża aktualność tematyki skłoniła mnie do podjęcia własnych badań.Cel badań. Celem pracy jest przedstawienie działań ratunkowych na etapie przedszpitalnym i szpitalnym (szpitalny oddział ratunkowy) u chorego z oparzeniem termicznym.Materiały i metody. Przy pisaniu tej pracy licencjackiej wykorzystano metodę analizy indywidualnego przypadku medycznego. Poddano analizie dokumentację medyczną pacjenta uzyskaną od Zespołu Ratownictwa Medycznego „P” oraz Szpitalnego Oddziału Ratunkowego.Wnioski. Ciężkie oparzenie może stanowić stan zagrożenia życia poszkodowanego. Właściwe postępowanie ratunkowe w ciężkim oparzeniu podjęte na miejscu zdarzenia ma kluczowe znaczenie dla ostatecznych efektów terapeutycznych. W postępowaniu ratunkowym u chorego po ciężkim urazie oparzeniowym szczególną uwagę należy zwrócić na ryzyko szybko rozwijających się zaburzeń w gospodarce wodno-elektrolitowej i wysoki poziom bólu ran oparzeniowych, co wymaga wdrożenia często intensywnej płynoterapii oraz leczenia przeciwbólowego. Leczenie ciężkich oparzeń wymaga często współpracy wieloośrodkowej, w tym podjęcia leczenia w centrum oparzeniowym.Introduction. Severe burns are a major problem in medicine. Severe burns entail multidirectional systemic disorders, the treatment of which may become very difficult for the paramedic. The high topicality of the subject prompted me to undertake my own research.The aim of the study. The aim of this study is to present the rescue actions at the prehospital and hospital (hospital emergency department) stages in a patient with thermal burn.Materials and methods. In writing this undergraduate thesis, the method of individual medical case analysis was used. The medical records of the patient obtained from the Emergency Medical Team "P" and the Hospital Emergency Department were analysed.Conclusions. A severe burn may be a life-threatening condition for the victim. Appropriate emergency management of severe burns undertaken at the scene is crucial for the final therapeutic outcome. In the emergency management of the patient after severe burn injury, special attention should be paid to the risk of rapidly developing water-electrolyte disturbances and high level of burn wound pain, which often requires implementation of intensive fluid therapy and analgesic treatment. The treatment of severe burns often requires multicentre cooperation, including the initiation of treatment in a burn centre

Fairy tale in advertising. Advertisement as a fairy tale.The ways of using literature in product promotion and culture in TV commercial

Celem pracy jest analiza reklam odwołujących się do dorobku literatury a dokładniej – baśni, oraz zbadanie wpływu owych reklam na promocję produktu i kultury. Praca przy pomocy odpowiednich narzędzi badawczych, takich jak analiza pogłębiona, obserwacja oraz komparatystyka, weryfikuje słuszność hipotez badawczych. Przyjęto w nich, że interpretowanie baśni w reklamach jest skutecznym zabiegiem marketingowym ze względu na odwoływanie się do pozytywnych wartości oraz emocji. Dodatkowo stwierdza się, iż używanie baśni w reklamie ma związek z współczesną kulturą konsumpcyjną, która osobom dorosłym stara się zaszczepić dziecięce gusta. Analizowany materiał podzielono na części, pierwsza baśń w reklamie odnosi się do spotów, w których wyraźny sposób przedstawiono konotacje z baśnią (bohater, fabuła, motyw). Druga reklama jako baśń odzwierciedla wszystkie reklamy, w których występuje schematyzm form strukturalnych charakterystycznych dla baśni. Wśród wniosków zostaje wprowadzona teoria współczesnej kultury konsumpcyjnej starającej się ujednolicić gusta odbiorców za sprawą przekazywania prostych, dziecinnych komunikatów.The topic of this thesis oscillates between issues connected with advertising and fairy tales trying to combine those two fields which seem to be quite distant to one another. According to the aim of the thesis the advertisements (mostly TV commercials) will be analyzed refering to the literature, in particular fairly tales. Moreover, the influence of these commercials will be examined in terms of product promotion and culture. With the use of the adequate research tools like advanced analysis, observation and comparative study, the rightness of the research hypothesis is being verified. According to the assumed knowledge the process of interpreting the commercials is the successful sales gimmick as it appeals to the positive values and emotions. Additionally, it is said that the use of fairy tales in advertising is related to the contemporary consumerist culture which tries to adopt the children’s style to adult people. The analyzed material has been divided into certain parts. The first one fairy tale in advertising appeals to the TV commercials where the connotations with fairy tales are emphasized in the plot, heroes or themes. The second one the advertisement as a fairy tale reflects all the advertisements where the schema of structural forms typical for fairy tales appears. What is drawn in the concluding part is the theory of the contemporary consumerist culture which tries to unify the taste of the consumers using simple and childish announcements

Phenomenon of the sexual violence amongst secondary school young people

Praca nad zjawiskiem przemocy seksualnej wśród młodzieży składa się z trzech części: części teoretycznej przedstawiającej przemoc seksualną oraz jej uwarunkowania, części metodologicznej, w której zawarte są główne problemy badawcze i rodzaje metod, które stanowiły podstawę do przeprowadzenia badań oraz części trzeciej, w której przedstawione zostały wyniki przeprowadzonych badań.W części teoretycznej przedstawione zostało zjawisko przemocy seksualnej opisywane w literaturze przedmiotu z uwzględnieniem rozwoju psychoseksualnego człowieka oraz wszelkie patologie wynikające z zaburzeń tego rozwoju, uwarunkowania biologiczne i społeczno-kulturowe rozwoju seksualnego człowieka w okresie adolescencji. W pracy również poruszany jest temat inicjacji seksualnej młodzieży i związanych z nią konsekwencji, rodzajów ryzykownych zachowań młodzieży a sferze seksualnej. Kolejną kwestią poruszaną w pracy jest przemoc seksualna, jej klasyfikacja według różnych autorów oraz problematyka związana z pojęciem przemocy i agresji seksualnej. Część tego rozdziału również poświęcona jest nowo powstającemu zjawisku sextingu wśród młodzieży, jako formy przemocy seksualnej generowanej nowymi technologiami, przyczynom przemocy seksualnej wśród młodzieży oraz krótkiej charakterystyki ofiar i sprawców przemocy seksualnej. W związku z tym, iż badania były przeprowadzane w szkole zostały przedstawione badania z zakresu zachowań seksualnych uczniów na terenie szkoły oraz szkolne programy profilaktyczne, które dotyczą obszaru seksualności człowieka. W metodologicznej części pracy przedstawione zostały problem główny oraz problemy szczegółowe, które pozwoliły na przedstawienie badanego zjawiska w sposób dokładny, zmienne i wskaźniki oraz metody i narzędzia badawcze, które zostały wykorzystane do przeprowadzenia badań. Tą część pracy zamyka przedstawienie charakterystyki badanej populacji oraz sposób opracowywania wyników. Struktura trzeciego rozdziału opracowana jest w oparciu o przedstawione problemy badawcze i składa się z dziewięciu podpunktów. Przy analizie badań uwzględniono formę i tematykę edukacji seksualnej w szkole, wiek pierwszej inicjacji seksualnej młodzieży, skąd młodzież czerpie informacje o seksie, dostępność pornografii, rodzaje przemocy seksualnej występujące wśród młodzieży oraz kim są ofiary i sprawcy przemocy seksualnej.Analizę badań podsumowują wnioski i uogólnienia oraz zakończenie. Praca opatrzona jest w aneks, który zawiera narzędzia badawcze, spis tabel i wykresów oraz bibliografię.Thesis on the occurrence of the sexual violence amongst young people consists of three parts: of the theoretical part describing the sexual violence and for her conditioning, the methodological part in which main research problems and kinds of methods which constituted the ground for conducting research are included and the third part, in which results were presented of conducted examinations.In part theoretical an occurrence of the sexual violence described in the literature on the subject including the development of the psychosexual man and all social pathologies resulting from disorders of this development were described, biological and social-cultural conditioning of development of the sexual man in the period of the adolescence.At the thesis a subject of the sexual initiation of young people and consequences associated with her is also being brought up, of types of risky behaviours of young people but for the sexual sphere. At the thesis a sexual violence is another matter brought up, her classification according to different authors and issues associated with comprehending the violence and the sexual aggression. The part of this chapter is also devoted to the newly occurring sextingu phenomenon amongst young people, as the sexual form of violence generated with new technologies, for reasons for the sexual violence amongst young people and a character sketch of victims and perpetrators of the sexual violence. Since examinations were conducted at school described examinations stayed from the scope of sexual behaviors of pupils on school grounds and school preventive programs which concern the area of the human sexuality.In the methodological part of the thesis a main problem and detailed problems which let describing the examined occurrence in the accurate way, variables and indicators, methods and research tools which were exploited were presented for auditing. Presenting the studied characterization is closing this part of the thesis of population and the way of drawing results up.The structure of the third chapter is drawn up based on presented research problems and consists of nine subsections. At analysis of examinations a form and a subject matter of the sexuality education were considered at school, age of the first sexual initiation of young people, where from young people are drawing information about the sex, availability of the pornography, types of the sexual violence appearing among young people as well as whom victims and perpetrators of the sexual violence are.Conclusions and generalizing and finishing are recapitulating analysis of examinations. The thesis is all-too-familiar into the appendix which contains research tools, the list of tables and graphs and the bibliography

The Efficiency of Burn Wounds Debridement with Use of Hydrosurgery - Our Experiences

The aim of the study was to present experience of doctors from the Center for Burns Treatment in Siemianowice Śląskie who use a Versajet system. Material and methods. Debridement with the use of a water jet was applied in 70 patients with IIbo /IIIo thermal burns in the period between 2009-2013. The corresponding evaluation involved duration of operation, locations, wound surfaces and technique of debridement after operation. Microbiological tests were also performed before and after debridement. Results and conclusions. In the paper, its authors draw attention to the short time of debridement. The application of a water jet allows precise debridement, particularly in hardly accessible places, preparation of wounds to be covered with autologous split thickness skin graft, protection of healthy tissues

Reversed-phase TLC study of some long chain arylpiperazine of imidazolidine-2,4-dione and imidazo[2,1-φ]purine-2,4-dione derivatives

The chromatographic parameters of arylpiperazinylpropyl derivatives of imidazolidine-2,4-dione and imidazo[2,1-f]purine-2,4-dione were investigated using reversed-phase thin layer chromatography method. The results revealed that RM0 of investigated compounds depended on substituent in arylpiperazinyl fragment as well as on a nature of (cycloalkyl)aromatic ring at 5 position of imidazolidine-2,4-dione and at 7 position of imidazo[2,1-f]theophylline. The RM0 parameters were compared with computationally calculated partition coefficients values by principal component analysis (PCA). To verify the influence of lipophilic parameter of investigated compounds on their biological activity the statistical analysis of Mann-Whitney was performed

Human Acellular Dermal Matrix in Reconstructive Surgery—A Review

Reconstructive surgery often confronts large tissue defects. This creates a need to look for materials that are immunogenic but offer the possibility of tissue filling. ADM—acellular dermal matrix—is a biological collagen matrix without immunogenicity, which is more commonly used in surgical treatment. Reconstructive surgery is still searching for various biocompatible materials that can be widely used in surgery. The available materials have their advantages and disadvantages. This paper is a literature review on the use of human acellular dermal matrix (ADM) in reconstructive surgery (surgical oncology, plastic and reconstructive surgery, and gynecologic reconstructive surgery). ADM appears to be a material of increasing use in various fields of surgery, and thus, further research in this area is required

The Phenolic Compounds Profile and Cosmeceutical Significance of Two Kazakh Species of Onions: Alliumgalanthum and A. turkestanicum

Numerous species of Allium genus have been used in the traditional medicine based on their vast biological effects, e.g., antimicrobial, digestion stimulant, anti-sclerotic, soothing, antiradical or wound healing properties. In this work, unpolar and polar extracts from two lesser-investigated species of Allium growing in Kazakhstan, Alliumgalanthum Kar. & Kir. (AG) and A. turkestanicum Regel. (AT), were studied for their composition and biological effects. In the HPLC-ESI-QTOF-MS/MS analyses of water and alcoholic extracts simple organic acids, flavonoids and their glycosides were found to be the best represented group of secondary metabolites. On the other hand, in the GC-MS analysis diethyl ether, extracts were found to be rich sources of straight-chain hydrocarbons and their alcohols, fatty acids and sterols. The antimicrobial activity assessment showed a lower activity of polar extracts, however, the diethyl ether extract from AT bulbs and AG chives showed the strongest activity against Bacillus subtilis ATCC 6633, B. cereus ATCC 10876, some species of Staphylococcus (S. aureus ATCC 25923 and S. epidermidis ATCC 12228) and all tested Candida species (Candida albicans ATCC 2091, Candida albicans ATCC 10231, Candida glabrata ATCC 90030, Candida krusei ATCC 14243 and Candida parapsilosis ATCC 22019) with a minimum inhibitory concentration of 0.125–0.5 mg/mL. The highest antiradical capacity exhibited diethyl ether extracts from AG bulbs (IC50 = 19274.78 ± 92.11 mg Trolox eq/g of dried extract) in DPPH assay. In ABTS scavenging assay, the highest value of mg Trolox equivalents, 50.85 ± 2.90 was calculated for diethyl ether extract from AT bulbs. The same extract showed the highest inhibition of mushroom tyrosinase (82.65 ± 1.28% of enzyme activity), whereas AG bulb ether extract was the most efficient murine tyrosinase inhibitor (54% of the enzyme activity). The performed tests confirm possible cosmeceutical applications of these plants