Simulated patient programmes in europe: collegiality or separate development?

Aims: In order for different SP programmes to learn from each other, there needs to be some basis for establishing meaningful comparisons. Method: In 2006, the Association of Standardized Patient Educators (ASPE) piloted a survey instrument that would facilitate comparisons of SP educational practices in different institutions. Four European countries at varying stages of SP programme development were selected as representative of the spread of SP experience in Europe (Belgium, Ireland, Scotland and the Netherlands). Key SP contacts were identified in each medical school. Contacts were asked to complete a 49-item questionnaire developed collaboratively between ASPE and the authors. The overall response rate was 86%. Results: There were considerable differences between countries in terms of their approach to developing SPs and quality assuring their performance. Whilst SP education was regarded as an expensive enterprise, there was little evidence of resource sharing between different centres in the same country. Conclusions: There is a clear need to facilitate closer collaboration between centres in developing and quality assuring SPs

Synthesis of benzothiophene-based hydroxamic acids as potent and selective HDAC6 inhibitors

A small library of 3-[(4-hydroxycarbamoylphenyl)aminomethyl]benzothiophenes was prepared and assessed as a novel class of HDAC6 inhibitors, leading to the identification of three representatives as potent and selective HDAC6 inhibitors. Further tests with regard to inflammatory responses indicated that HDAC6 inhibition can be uncoupled from transcriptional inhibition at the level of activated NF-κB, AP-1, and GR.crosscheck: This document is CrossCheck deposited related_data: Supplementary Information copyright_licence: The Royal Society of Chemistry has an exclusive publication licence for this journal history: Received 23 April 2015; Accepted 11 May 2015; Accepted Manuscript published 11 May 2015; Advance Article published 21 May 2015; Version of Record published 2 June 2015status: publishe

Synthesis of benzothiophene-based hydroxamic acids as potent and selective HDAC6 inhibitors

A small library of 3-[(4-hydroxycarbamoylphenyl)aminomethyl]-benzothiophenes was prepared and assessed as a novel class of HDAC6 inhibitors, leading to the identification of three representatives as potent and selective HDAC6 inhibitors. Further tests with regard to inflammatory responses indicated that HDAC6 inhibition can be uncoupled from transcriptional inhibition at the level of activated NF-kappa B, AP-1, and GR

Simulated patient programmes in Europe:collegiality or separate development

Aims: In order for different SP programmes to learn from each other, there needs to be some basis for establishing meaningful comparisons. Method: In 2006, the Association of Standardized Patient Educators (ASPE) piloted a survey instrument that would facilitate comparisons of SP educational practices in different institutions. Four European countries at varying stages of SP programme development were selected as representative of the spread of SP experience in Europe (Belgium, Ireland, Scotland and the Netherlands). Key SP contacts were identified in each medical school. Contacts were asked to complete a 49-item questionnaire developed collaboratively between ASPE and the authors. The overall response rate was 86%. Results: There were considerable differences between countries in terms of their approach to developing SPs and quality assuring their performance. Whilst SP education was regarded as an expensive enterprise, there was little evidence of resource sharing between different centres in the same country. Conclusions: There is a clear need to facilitate closer collaboration between centres in developing and quality assuring SPs